Blood, sweat, and tears: Red Blood Cell‐Omics study objectives, design, and recruitment activities

The Red Blood Cell (RBC)‐Omics study was initiated to build a large data set containing behavioral, genetic, and biochemical characteristics of blood donors with linkage to outcomes of the patients transfused with their donated RBCs.

[1]  A. D’Alessandro,et al.  Oxidative modifications of glyceraldehyde 3-phosphate dehydrogenase regulate metabolic reprogramming of stored red blood cells. , 2016, Blood.

[2]  Kari Stefansson,et al.  A genetic risk factor for periodic limb movements in sleep. , 2007, The New England journal of medicine.

[3]  J. Danesh,et al.  Efficiency and safety of varying the frequency of whole blood donation (INTERVAL): a randomised trial of 45 000 donors , 2017, The Lancet.

[4]  A. D’Alessandro,et al.  Metabolomics in transfusion medicine , 2016, Transfusion.

[5]  S. Glynn,et al.  Iron deficiency in blood donors: analysis of enrollment data from the REDS‐II Donor Iron Status Evaluation (RISE) study , 2011, Transfusion.

[6]  Lisa M. Schwartz,et al.  A genetic risk factor for periodic limb movements in sleep. , 2008, The New England journal of medicine.

[7]  W. Hening,et al.  Validation of the self-completed Cambridge-Hopkins questionnaire (CH-RLSq) for ascertainment of restless legs syndrome (RLS) in a population survey. , 2009, Sleep medicine.

[8]  J. Hess.  Scientific problems in the regulation of red blood cell products , 2012, Transfusion.

[9]  Grier P Page,et al.  Ethnicity, sex, and age are determinants of red blood cell storage and stress hemolysis: results of the REDS-III RBC-Omics study. , 2017, Blood advances.

[10]  Christian Gieger,et al.  Genome-wide association study of restless legs syndrome identifies common variants in three genomic regions , 2007, Nature Genetics.

[11]  M. Melbye,et al.  Survival after blood transfusion , 2008, Transfusion.

[12]  Janet S. Lee,et al.  Sickle Cell Trait Increases Red Blood Cell Storage Hemolysis and Post-Transfusion Clearance in Mice , 2016, EBioMedicine.

[13]  J. Cook,et al.  Effect of blood donation on iron stores as evaluated by serum ferritin , 1977 .

[14]  William J. Astle,et al.  Allelic Landscape of Human Blood Cell Trait Variation and Links , 2016 .

[15]  M. Gladwin,et al.  Testosterone‐dependent sex differences in red blood cell hemolysis in storage, stress, and disease , 2016, Transfusion.

[16]  H. Howie,et al.  Metabolic pathways that correlate with post-transfusion circulation of stored murine red blood cells , 2016, Haematologica.

[17]  Melanie C. Chansky,et al.  Qualitative assessment of pica experienced by frequent blood donors , 2017, Transfusion.

[18]  Aarash Bordbar,et al.  Development and evaluation of a transfusion medicine genome wide genotyping array , 2018, Transfusion.

[19]  S. Glynn,et al.  The red blood cell storage lesion: a method to the madness , 2010, Transfusion.

[20]  P. J. Norris,et al.  The effect of processing method on the in vitro characteristics of red blood cell products , 2015, Vox sanguinis.

[21]  K. Rostgaard,et al.  Length of Storage of Red Blood Cells and Patient Survival After Blood Transfusion , 2016, Annals of Internal Medicine.

[22]  J. Danesh,et al.  Recruitment and representativeness of blood donors in the INTERVAL randomised trial assessing varying inter-donation intervals , 2016, Trials.

[23]  H. Ullum,et al.  Genetic factors influencing ferritin levels in 14,126 blood donors: results from the Danish Blood Donor Study , 2016, Transfusion.

[24]  O. Nyrén,et al.  Should plasma from female donors be avoided? A population‐based cohort study of plasma recipients in Sweden from 1990 through 2002 , 2010, Transfusion.

[25]  H. Hjalgrim,et al.  Red Blood Cell Concentrate Storage and Survival After Cardiac Surgery. , 2015, JAMA.

[26]  E. Hod,et al.  Hypoxia modulates the purine salvage pathway and decreases red blood cell and supernatant levels of hypoxanthine during refrigerated storage , 2017, Haematologica.

[27]  Grier P Page,et al.  Frequent blood donations alter susceptibility of red blood cells to storage‐ and stress‐induced hemolysis , 2018, Transfusion.

[28]  D. Bellissimo,et al.  Behavioral, biochemical, and genetic analysis of iron metabolism in high‐intensity blood donors , 2008, Transfusion.

[29]  M Reilly,et al.  A population‐based binational register for monitoring long‐term outcome and possible disease concordance among blood donors and recipients , 2006, Vox sanguinis.

[30]  J. Cook,et al.  Effect of blood donation on iron stores as evaluated by serum ferritin. , 1977, Blood.

[31]  B. Palsson,et al.  Proceedings of the Food and Drug Administration's public workshop on new red blood cell product regulatory science 2016 , 2018, Transfusion.

[32]  Richard P Allen,et al.  Prevalence and disease burden of primary restless legs syndrome: Results of a general population survey in the United States , 2011, Movement disorders : official journal of the Movement Disorder Society.