Fe-Doped Sol-Gel Glasses and Glass-Ceramics for Magnetic Hyperthermia

This work deals with the synthesis and characterization of novel Fe-containing sol-gel materials obtained by modifying the composition of a binary SiO2-CaO parent glass with the addition of Fe2O3. The effect of different processing conditions (calcination in air vs. argon flowing) on the formation of magnetic crystalline phases was investigated. The produced materials were analyzed from thermal (hot-stage microscopy, differential thermal analysis, and differential thermal calorimetry) and microstructural (X-ray diffraction) viewpoints to assess both the behavior upon heating and the development of crystalline phases. N2 adsorption–desorption measurements allowed determining that these materials have high surface area (40–120 m2/g) and mesoporous texture with mesopore size in the range of 18 to 30 nm. It was assessed that the magnetic properties can actually be tailored by controlling the Fe content and the environmental conditions (oxidant vs. inert atmosphere) during calcination. The glasses and glass-ceramics developed in this work show promise for applications in bone tissue healing which require the use of biocompatible magnetic implants able to elicit therapeutic actions, such as hyperthermia for bone cancer treatment.

[1]  M. Mozafari,et al.  Strontium- and cobalt-substituted bioactive glasses seeded with human umbilical cord perivascular cells to promote bone regeneration via enhanced osteogenic and angiogenic activities. , 2017, Acta biomaterialia.

[2]  M. Miola,et al.  Multifunctional ferrimagnetic glass–ceramic for the treatment of bone tumor and associated complications , 2017, Journal of Materials Science.

[3]  R. Carbone,et al.  In vitro biocompatibility of a ferrimagnetic glass-ceramic for hyperthermia application. , 2017, Materials science & engineering. C, Materials for biological applications.

[4]  F. Baino,et al.  Electrophoretic deposition of spray-dried Sr-containing mesoporous bioactive glass spheres on glass–ceramic scaffolds for bone tissue regeneration , 2017, Journal of Materials Science.

[5]  F. Baino,et al.  Bioactive glass-based materials with hierarchical porosity for medical applications: Review of recent advances. , 2016, Acta biomaterialia.

[6]  F. Baino,et al.  Antibacterial Bioglass-Derived Scaffolds: Innovative Synthesis Approach and Characterization , 2016 .

[7]  Nishant Shankhwar,et al.  Evaluation of sol-gel based magnetic 45S5 bioglass and bioglass-ceramics containing iron oxide. , 2016, Materials science & engineering. C, Materials for biological applications.

[8]  Ying Dai,et al.  Effects of Iron Oxide on the Crystallization of Calcium Alumino-Silicate Glass , 2016 .

[9]  M. Marcacci,et al.  Magnetic forces and magnetized biomaterials provide dynamic flux information during bone regeneration , 2016, Journal of Materials Science: Materials in Medicine.

[10]  Olivier Sandre,et al.  Fundamentals and advances in magnetic hyperthermia , 2015, Applied Physics Reviews.

[11]  A. Cochis,et al.  Composite bone cements loaded with a bioactive and ferrimagnetic glass-ceramic: Leaching, bioactivity and cytocompatibility. , 2015, Materials science & engineering. C, Materials for biological applications.

[12]  J. P. Olivier,et al.  Physisorption of gases, with special reference to the evaluation of surface area and pore size distribution (IUPAC Technical Report) , 2015 .

[13]  A. Boccaccini,et al.  Effect of ion release from Cu-doped 45S5 Bioglass® on 3D endothelial cell morphogenesis. , 2015, Acta biomaterialia.

[14]  Jiang Chang,et al.  Multifunctional mesoporous bioactive glasses for effective delivery of therapeutic ions and drug/growth factors. , 2014, Journal of controlled release : official journal of the Controlled Release Society.

[15]  R. Breault,et al.  Kinetics of Magnetite (Fe3O4) Oxidation to Hematite (Fe2O3) in Air for Chemical Looping Combustion , 2014 .

[16]  M. Gutiérrez,et al.  Induction of bone formation in abdominal implants constituted by collagen sponges embedded with plant-based human transforming growth factor family proteins in ectopic dog model , 2014, Journal of Experimental Orthopaedics.

[17]  J. Mano,et al.  Magnetic composite biomaterials for tissue engineering. , 2014, Biomaterials science.

[18]  M. Miola,et al.  Composite bone cements loaded with a bioactive and ferrimagnetic glass-ceramic. Part I: Morphological, mechanical and calorimetric characterization , 2014, Journal of biomaterials applications.

[19]  Alexander V. Neimark,et al.  Density functional theory methods for characterization of porous materials , 2013 .

[20]  Jianhua Zhang,et al.  Preparation and Characterization of Magnetic Mesoporous Bioactive Glass/Carbon Composite Scaffolds , 2013 .

[21]  J. Rincón,et al.  Understanding the Crystallization Mechanism of a Wollastonite Base Glass Using Isoconversional, IKP Methods and Master Plots , 2012 .

[22]  G. Cuniberti,et al.  Multifunctional magnetic mesoporous bioactive glass scaffolds with a hierarchical pore structure. , 2011, Acta biomaterialia.

[23]  Stefan Kaskel,et al.  Proliferation, differentiation and gene expression of osteoblasts in boron-containing associated with dexamethasone deliver from mesoporous bioactive glass scaffolds. , 2011, Biomaterials.

[24]  C. Kumar,et al.  Magnetic nanomaterials for hyperthermia-based therapy and controlled drug delivery. , 2011, Advanced drug delivery reviews.

[25]  Francesco Baino,et al.  Three-dimensional glass-derived scaffolds for bone tissue engineering: current trends and forecasts for the future. , 2011, Journal of biomedical materials research. Part A.

[26]  Delbert E Day,et al.  Bioactive glass in tissue engineering. , 2011, Acta biomaterialia.

[27]  Aldo R Boccaccini,et al.  A review of the biological response to ionic dissolution products from bioactive glasses and glass-ceramics. , 2011, Biomaterials.

[28]  J. Bloemendal,et al.  Analysis on variety and characteristics of maghemite , 2010 .

[29]  Jerry S. H. Lee,et al.  Magnetic nanoparticles in MR imaging and drug delivery. , 2008, Advanced drug delivery reviews.

[30]  C. Robic,et al.  Magnetic iron oxide nanoparticles: synthesis, stabilization, vectorization, physicochemical characterizations, and biological applications. , 2008, Chemical reviews.

[31]  G. Kothiyal,et al.  Influence of iron ions on the magnetic properties of CaO-SiO2-P2O5-Na2O-Fe2O3 glass-ceramics , 2008 .

[32]  A. Georgoulis,et al.  Synthesis and characterization of sol–gel derived bioactive CaO–SiO2–P2O5 glasses containing magnetic nanoparticles , 2008 .

[33]  L. Pereira,et al.  Precipitation of zinc ferrite nanoparticles in the Fe2O3–ZnO–SiO2 glass system , 2007 .

[34]  P. Tiberto,et al.  Magnetic properties of the ferrimagnetic glass-ceramics for hyperthermia , 2006 .

[35]  Tadashi Kokubo,et al.  How useful is SBF in predicting in vivo bone bioactivity? , 2006, Biomaterials.

[36]  Julian R Jones,et al.  Hierarchical porous materials for tissue engineering , 2006, Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences.

[37]  S. Spriano,et al.  The influence of crystallised Fe3O4 on the magnetic properties of coprecipitation-derived ferrimagnetic glass-ceramics. , 2005, Acta biomaterialia.

[38]  E. Culea,et al.  Magnetic and structural behaviour of the sol gel-derived iron aluminosilicate glass-ceramics , 2005 .

[39]  Mar Alvarez,et al.  Formation of crystalline phases in (SiO2–CaO–Fe2O3)–TiO2 based glasses , 2005 .

[40]  M. Pascual,et al.  Glass-forming ability, sinterability and thermal properties in the systems RO–BaO–SiO2 (R = Mg, Zn) , 2004 .

[41]  Dhirendra Bahadur,et al.  Biomaterials and magnetism , 2003 .

[42]  D. Avnir,et al.  Recommendations for the characterization of porous solids (Technical Report) , 1994 .

[43]  T. Matsuda.  [Hyperthermia in the treatment of cancer]. , 1986, Gan to kagaku ryoho. Cancer & chemotherapy.

[44]  K. Sing.  Reporting physisorption data for gas/solid systems with special reference to the determination of surface area and porosity (Recommendations 1984) , 1985 .

[45]  C. Hurd.  Varieties of magnetic order in solids , 1982 .

[46]  T. Komatsu,et al.  ESR and Mössbauer studies of crystallization process of sodium iron silicate glass , 1980 .

[47]  S. T. Lin.  Magnetic Properties of Hematite Single Crystals. I. Magnetization Isotherms, Antiferromagnetic Susceptibility, and Weak Ferromagnetism of a Natural Crystal , 1959 .

[48]  E. Teller,et al.  ADSORPTION OF GASES IN MULTIMOLECULAR LAYERS , 1938 .

[49]  Kevin Braeckmans,et al.  Investigating the toxic effects of iron oxide nanoparticles. , 2012, Methods in enzymology.

[50]  N. Sel’menskikh,et al.  Crystallization of oxide high iron melts , 2011 .

[51]  D. H. Everett,et al.  INTERNATIONAL UNION OF PURE AND APPLIED CHEMISTRY PHYSICAL CHEMISTRY DIVISION COMMISSION ON COLLOID AND SURFACE CHEMISTRY* Subcommittee on Characterization of Porous Solids RECOMMENDATIONS FOR THE CHARACTERIZATION OF POROUS SOLIDS , 2004 .

[52]  L. Hench,et al.  Characterization of melt-derived 45S5 and sol-gel-derived 58S bioactive glasses. , 2001, Journal of biomedical materials research.

[53]  Yong-Keun Lee,et al.  Controlled nucleation and crystallization in Fe2O3–CaO–SiO2 glass , 1997 .