Drugs and postural sway: quantifying balance as a tool to measure drug effects

Research aimed at modeling the relationship of the center of gravity (COG) to the center of pressure (COP) and testing alternative clinically useful measures of postural stability that are based on the COG and COP is described. Postural sway is spontaneous involuntary body movements that result from the neuromuscular corrective mechanisms acting to preserve static posture, such as standing or sitting. The second aim of the research is to implement clinically relevant measures of postural stability, such as the limits of stability, in the context of the ongoing examination of the effects of drugs on balance. Preliminary results and directions of future research are outlined.<<ETX>>

[1]  J M Mol,et al.  Standardization in platform stabilometry being a part of posturography. , 1983, Agressologie: revue internationale de physio-biologie et de pharmacologie appliquees aux effets de l'agression.

[2]  Ernest P Hanavan,et al.  A mathematical model of the human body , 1964 .

[3]  T. Kapteyn,et al.  Standarization in platform stabilometry being apart of posturography , 1983 .

[4]  David A. Winter,et al.  C of P vs. C of G changes quiet stance and voluntary sway in the frontal and sagittal planes , 1989 .

[5]  S. Studenski,et al.  Functional reach: a new clinical measure of balance. , 1990, Journal of gerontology.

[6]  R. Shiavi,et al.  Dose–related effect of triazolam on postural sway , 1991, Clinical pharmacology and therapeutics.

[7]  Rolf Johansson,et al.  Human postural dynamics. , 1991, Critical reviews in biomedical engineering.

[8]  M. Tinetti,et al.  Risk factors for falls among elderly persons living in the community. , 1988, The New England journal of medicine.

[9]  L. Nashner,et al.  Sensory, neuromuscular, and biochemical contributions to human balance , 1989 .

[10]  Murray Mp,et al.  Center of gravity, center of pressure, and supportive forces during human activities. , 1967 .

[11]  T. Shimba.  An estimation of center of gravity from force platform data. , 1984, Journal of biomechanics.

[12]  Robert B. McGhee,et al.  On the Role of Dynamic Models in Quantitative Posturography , 1980, IEEE Transactions on Biomedical Engineering.

[13]  E V Gurfinkel,et al.  Physical foundations of stabilography. , 1973, Agressologie: revue internationale de physio-biologie et de pharmacologie appliquees aux effets de l'agression.

[14]  L. Melton,et al.  Psychotropic drug use and the risk of hip fracture. , 1987, The New England journal of medicine.

[15]  A. Seireg,et al.  Biochemical Analysis Of The Musculoskeletal Structure For Medicine And Sports , 1989 .

[16]  David A. Winter,et al.  Sagittal Plane Balance and Posture in Human Walking , 1987, IEEE Engineering in Medicine and Biology Magazine.

[17]  S.S. Hasan,et al.  Selecting A Suitable Biomechanics Platforn Measure Of Sway , 1990, [1990] Proceedings of the Twelfth Annual International Conference of the IEEE Engineering in Medicine and Biology Society.

[18]  E E MUELLER,et al.  Influence of lower extremity amputation on stance mechanics. , 1950, Journal of the American Medical Association.

[19]  L. Rubenstein,et al.  Predictors of falls among elderly people. Results of two population-based studies. , 1989, Archives of internal medicine.

[20]  M C Burger,et al.  Clinical Determinants of Biomechanics Platform Measures of Balance in Aged Women , 1988, Journal of the American Geriatrics Society.

[21]  S. Hasan,et al.  Effect of loss of balance on biomechanics platform measures of sway: influence of stance and a method for adjustment. , 1990, Journal of biomechanics.

[22]  D. Winter,et al.  Assessment of balance control in humans. , 1990, Medical progress through technology.

[23]  P. Goldie,et al.  Force platform measures for evaluating postural control: reliability and validity. , 1989, Archives of physical medicine and rehabilitation.

[24]  A J Spaepen,et al.  Comparison of the movements of the center of gravity and of the center of pressure in stabilometric studies. , 1977, Agressologie: revue internationale de physio-biologie et de pharmacologie appliquees aux effets de l'agression.

[25]  R W Mann,et al.  Modelling of the biomechanics of posture and balance. , 1990, Journal of biomechanics.

[26]  R. Soutas-Little,et al.  Role Of Ground Reaction Torque In Postural Stability , 1991, Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society Volume 13: 1991.

[27]  Gurfinkel Ev,et al.  Physical foundations of stabilography. , 1973 .

[28]  A. Seireg,et al.  Normal postural stability and steadiness: quantitative assessment. , 1975, The Journal of bone and joint surgery. American volume.