A comparison of trimethorprim-sulfamethoxazole with sulfamethoxazole alone in infections localized to the kidneys.

Ninety patients with urinary tract infections were treated in a randomized double-blind study with either a combination of trimethoprim and sulfamethoxazole (TMP-SMX) or sulfamethoxazole alone (SMX). Thirty of 42 patients treated with TMP-SMX were cured by the time of follow-up compared with 26 of 48 treated with SMX alone. Of the 29 patients infected with SMX-resistent organisms, the combination TMP-SMX cured 12 of 17, whereas SMX alone cured 2 of 12. Of the 61 patients infected with SMX-sensitive organisms, TMP-SMX cured 18 of 25; SMX alone cured 24 of 36. In 50 women the infection was found localized to The upper urinary tract by the use of the Fairley bladder washout technique. TMPsmx cured 16 or 24 of these patients with proved upper tract infections and SMX alone cured 11 of 26. Although none of these differences were significant, TMP-SMX appears to be an effective drug combination for the therapy of proved upper tract infection and is also effective in eradicating sulfonamide-resistant organisms.

[1]  G. Harding,et al.  A controlled study of antimicrobial prophylaxis of recurrent urinary infection in women. , 1974, The New England journal of medicine.

[2]  G. Lemieux Trimethoprim-sulfamethoxazole compared with sulfamethoxazole in urinary tract infection. , 1974, Canadian Medical Association journal.

[3]  A. Shelokov,et al.  Antibody-coated bacteria in the urine and the site of urinary-tract infection. , 1974, The New England journal of medicine.

[4]  G. Harding,et al.  Efficacy of Trimethoprim-Sulfamethoxazole in Bacteriuria , 1973 .

[5]  R. Gleckman A cooperative controlled study of the use of trimethoprim-sulfamethoxazole in chronic urinary tract infections. , 1973, The Journal of infectious diseases.

[6]  W. Brumfitt,et al.  Trimethoprim-sulfamethoxazole in the treatment of bacteriuria in women. , 1973, The Journal of infectious diseases.

[7]  W. Brumfitt,et al.  TRIMETHOPRIM/SULPHAMETHOXAZOLE IN THE TREATMENT OF URINARY INFECTION , 1973, The Medical journal of Australia.

[8]  C. McDonnell,et al.  The combination of trimethoprim and sulfamethoxazole in the treatment of urinary tract infection. , 1972, Canadian Medical Association journal.

[9]  W. Brumfitt,et al.  Double-blind Trial to Compare Ampicillin, Cephalexin, Co-trimoxazole, and Trimethoprim in Treatment of Urinary Infection , 1972, British medical journal.

[10]  D. Smith,et al.  DOUBLE‐BLIND TRIAL COMPARING TRIMETHOPRIM‐SULPHAMETHOXAZOLE (BACTRIM) WITH AMPICILLIN IN TREATING URINARY INFECTIONS , 1972, The Medical journal of Australia.

[11]  A. Ronald,et al.  Urinary infection localization. , 1972, American journal of obstetrics and gynecology.

[12]  L. Sourander,et al.  TREATMENT OF SULFONAMIDE‐RESISTANT URINARY TRACT INFECTIONS WITH A COMBINATION OF SULFONAMIDE AND TRIMETHOPRIM , 1972, Acta medica Scandinavica.

[13]  H. Dargie,et al.  Long-Term Trimethoprim-Sulphamethoxazole in the Management of Recurrent Urinary Infection , 1971, Scottish Medical Journal.

[14]  H. Gavras,et al.  Extended Therapy with a Trimethoprim-Sulphonamide for the Treatment of Established Urinary Tract Infection , 1971, Scottish medical journal.

[15]  B. Stratford,et al.  RESULTS OF TREATMENT OF 108 PATIENTS USING TRIMETHOPRIM PLUS SULPHAMETHOXAZOLE , 1971, The Medical journal of Australia.

[16]  R. Grüneberg,et al.  Trimethoprim in the Treatment of Urinary Infections in Hospital , 1969, British medical journal.

[17]  D. Reeves,et al.  Trimethoprim-Sulphamethoxazole: Comparative Study in Urinary Infection in Hospital , 1969, British medical journal.

[18]  J. Darrell,et al.  Trimethoprim: laboratory and clinical studies , 1968, Journal of clinical pathology.

[19]  K. Fairley,et al.  Simple test to determine the site of urinary-tract infection. , 1967, Lancet.

[20]  E. Steers,et al.  An inocula replicating apparatus for routine testing of bacterial susceptibility to antibiotics. , 1959, Antibiotics & chemotherapy.

[21]  Joan. Taylor IDENTIFICATION OF ENTEROBACTERIACEAE , 1956 .