Palladium-N-heterocyclic carbene (NHC) catalyzed C–N bond formation in a continuous flow microreactor. Effect of process parameters and comparison with batch operation

[1]  S. Kuhn,et al.  Continuous-flow precipitation of hydroxyapatite in ultrasonic microsystems , 2013 .

[2]  J. García-García,et al.  Design, fabrication and characterization of microreactors for high temperature syntheses , 2012 .

[3]  S. Guido,et al.  Vorticity banding in biphasic polymer blends. , 2012, Langmuir : the ACS journal of surfaces and colloids.

[4]  S. Nolan,et al.  An Efficient Palladium‐NHC (NHC=N‐Heterocyclic Carbene) and Aryl Amination Pre‐Catalyst: [Pd(IPr*)(cinnamyl)Cl] , 2012 .

[5]  Mais J. Jebrail,et al.  Digital microfluidics: a versatile tool for applications in chemistry, biology and medicine. , 2012, Lab on a chip.

[6]  C. Misbah,et al.  Red blood cell clustering in Poiseuille microcapillary flow , 2012 .

[7]  Dan Gao,et al.  Recent developments in microfluidic devices for in vitro cell culture for cell-biology research , 2012 .

[8]  A. Slawin,et al.  [Pd(IPr*)(cinnamyl)Cl]: an efficient pre-catalyst for the preparation of tetra-ortho-substituted biaryls by Suzuki-Miyaura cross-coupling. , 2012, Chemistry.

[9]  K. Mae,et al.  Direct carbonylation of nitrobenzene to phenylisocyanate using gas–liquid slug flow in microchannel , 2012 .

[10]  Timothy Noël,et al.  Cross-coupling in flow. , 2011, Chemical Society reviews.

[11]  S. Nolan,et al.  N-Heterocyclic carbene (NHC) ligands and palladium in homogeneous cross-coupling catalysis: a perfect union. , 2011, Chemical Society reviews.

[12]  Nicholas E. Leadbeater,et al.  A Continuous-Flow Approach to Palladium-Catalyzed Alkoxycarbonylation Reactions , 2011 .

[13]  Jc Jaap Schouten,et al.  Single-phase fluid flow distribution and heat transfer in microstructured reactors , 2011 .

[14]  M. Paraschivoiu,et al.  Single-phase fluid flow and mixing in microchannels , 2011 .

[15]  Norbert Kockmann,et al.  Scale-up concept of single-channel microreactors from process development to industrial production , 2011 .

[16]  J. V. van Hest,et al.  Continuous flow azide formation: Optimization and scale-up , 2011 .

[17]  Valentina Preziosi,et al.  Microfluidics analysis of red blood cell membrane viscoelasticity. , 2011, Lab on a chip.

[18]  Jun-ichi Yoshida,et al.  Cross-coupling in a flow microreactor: space integration of lithiation and Murahashi coupling. , 2010, Angewandte Chemie.

[19]  S. Buchwald,et al.  Dialkylbiaryl Phosphines in Pd-Catalyzed Amination: A User's Guide. , 2010, Chemical science.

[20]  M. Minale,et al.  Microconfined shear deformation of a droplet in an equiviscous non-newtonian immiscible fluid: experiments and modeling. , 2010, Langmuir : the ACS journal of surfaces and colloids.

[21]  Haibin Song,et al.  Highly Active, Well-Defined (Cyclopentadiene)(N-heterocyclic carbene)palladium Chloride Complexes for Room-Temperature Suzuki–Miyaura and Buchwald–Hartwig Cross-Coupling Reactions of Aryl Chlorides and Deboronation Homocoupling of Arylboronic Acids , 2009 .

[22]  Andreas Kirschning,et al.  Chemistry in flow systems , 2009, Beilstein journal of organic chemistry.

[23]  J. Hartwig Evolution of a fourth generation catalyst for the amination and thioetherification of aryl halides. , 2008, Accounts of chemical research.

[24]  S. Nolan,et al.  Well-defined N-heterocyclic carbenes-palladium(II) precatalysts for cross-coupling reactions. , 2008, Accounts of chemical research.

[25]  N. Kockmann,et al.  Microreactor Technology and Continuous Processes in the Fine Chemical and Pharmaceutical Industry: Is the Revolution Underway? , 2008 .

[26]  Cory Valente,et al.  Pd-catalyzed aryl amination mediated by well defined, N-heterocyclic carbene (NHC)-Pd precatalysts, PEPPSI. , 2008, Chemistry.

[27]  S. Buchwald,et al.  Palladium‐Catalyzed Aromatic Carbon‐Nitrogen Bond Formation , 2008 .

[28]  S. Morin,et al.  Pd PEPPSI-IPr-mediated reactions in metal-coated capillaries under MACOS: the synthesis of indoles by sequential aryl amination/Heck coupling. , 2008, Chemistry.

[29]  G. Whitesides The origins and the future of microfluidics , 2006, Nature.

[30]  Masaaki Sato,et al.  Low pressure Pd-catalyzed carbonylation in an ionic liquid using a multiphase microflow system. , 2006, Chemical communications.

[31]  S. Buchwald,et al.  A highly active catalyst for Suzuki-Miyaura cross-coupling reactions of heteroaryl compounds. , 2006, Angewandte Chemie.

[32]  Nicolas Marion,et al.  (IPr)Pd(acac)Cl: an easily synthesized, efficient, and versatile precatalyst for C-N and C-C bond formation. , 2006, The Journal of organic chemistry.

[33]  Jianguo Mei,et al.  Modified (NHC)Pd(allyl)Cl (NHC = N-heterocyclic carbene) complexes for room-temperature Suzuki-Miyaura and Buchwald-Hartwig reactions. , 2006, Journal of the American Chemical Society.

[34]  S. Buchwald,et al.  Reevaluation of the mechanism of the amination of aryl halides catalyzed by BINAP-ligated palladium complexes. , 2006, Journal of the American Chemical Society.

[35]  Yong Wang,et al.  Review of developments in portable hydrogen production using microreactor technology. , 2004, Chemical reviews.

[36]  F. Diederich,et al.  Book review: Metal-catalyzed cross-coupling reactions. F. Diederich and P. J. Stang (eds) Wiley–VCH, Weinheim, 1998. xxi + 517 pages, £85 ISBN 3–527–29421–X , 1998 .

[37]  Masaaki Sato,et al.  Continuous microflow synthesis of butyl cinnamate by a Mizoroki-Heck reaction using a low-viscosity ionic liquid as the recycling reaction medium , 2004 .

[38]  J. Hartwig Palladium‐Catalyzed Amination of Aryl Halides and Related Reactions , 2003 .

[39]  Sambasivarao Kotha,et al.  Recent applications of the Suzuki–Miyaura cross-coupling reaction in organic synthesis , 2002 .

[40]  G. C. Fu,et al.  Palladium-catalyzed coupling reactions of aryl chlorides. , 2002, Angewandte Chemie.

[41]  S. Nolan,et al.  An air-stable palladium/N-heterocyclic carbene complex and its reactivity in aryl amination. , 2002, Organic letters.

[42]  G. C. Fu,et al.  Versatile Catalysts for the Suzuki Cross-Coupling of Arylboronic Acids with Aryl and Vinyl Halides and Triflates under Mild Conditions , 2000 .

[43]  S. Buchwald,et al.  A Simple Catalytic Method for the Conversion of Aryl Bromides to Arylamines , 1995 .

[44]  J. Hartwig,et al.  Palladium-catalyzed synthesis of arylamines from aryl halides. Mechanistic studies lead to coupling in the absence of tin reagents , 1995 .

[45]  D. Hughes,et al.  Mechanistic Studies of the Suzuki Cross-Coupling Reaction , 1994 .

[46]  M. Kosugi,,et al.  PALLADIUM-CATALYZED AROMATIC AMINATION OF ARYL BROMIDES WITH N,N-DI-ETHYLAMINO-TRIBUTYLTIN , 1983 .

[47]  P. Woias,et al.  Multiphase minireactor system for direct fluorination of ethylene carbonate , 2012 .