Neutrophil count predicts clinical outcome in hospitalized COVID‐19 patients: Results from the NOR‐Solidarity trial

studies on SARS-CoV-2-induced inflammation, we still lack markers for rapid disease progression with admission to intensive care unit (ICU) or respiratory failure (RF). Few studies have evaluated the prognostic value of routine diagnostic repertoire available at most hospitals. The NOR-Solidarity trial is an independent add-on study to the WHO Solidarity trial, evaluating hydroxychloroquine (HCQ) and remdesivir compared to standard of care in hospitalized COVID-19 patients [1]. We explored whether standard biomarkers in peripheral blood could give information on ICU admission and RF in hospitalized COVID-19 patients. Routine Markers included were C-reactive intervention,

[1]  Inge Christoffer Olsen,et al.  Evaluation of the Effects of Remdesivir and Hydroxychloroquine on Viral Clearance in COVID-19 , 2021, Annals of Internal Medicine.

[2]  Jian-an Jia,et al.  Lymphocyte–monocyte–neutrophil index: a predictor of severity of coronavirus disease 2019 patients produced by sparse principal component analysis , 2021, Virology Journal.

[3]  Jordan J. Clark,et al.  Co-infections, secondary infections, and antimicrobial use in patients hospitalised with COVID-19 during the first pandemic wave from the ISARIC WHO CCP-UK study: a multicentre, prospective cohort study , 2021, The Lancet. Microbe.

[4]  R. Pranata,et al.  Prognostic value of elevated lactate dehydrogenase in patients with COVID-19: a systematic review and meta-analysis , 2021, Postgraduate Medical Journal.

[5]  K. Stavem,et al.  Dyspnoea, lung function and CT findings 3 months after hospital admission for COVID-19 , 2020, European Respiratory Journal.

[6]  A. Andiappan,et al.  Whole blood immunophenotyping uncovers immature neutrophil-to-VD2 T-cell ratio as an early marker for severe COVID-19 , 2020, Nature Communications.

[7]  R. Malekzadeh,et al.  Repurposed antiviral drugs for COVID-19; interim WHO SOLIDARITY trial results , 2020, medRxiv.

[8]  T. Hwang,et al.  Targeting Neutrophils to Treat Acute Respiratory Distress Syndrome in Coronavirus Disease , 2020, Frontiers in Pharmacology.

[9]  Haolong Li,et al.  Ferritin in the coronavirus disease 2019 (COVID‐19): A systematic review and meta‐analysis , 2020, Journal of clinical laboratory analysis.

[10]  C. Takiya,et al.  The emerging role of neutrophil extracellular traps in severe acute respiratory syndrome coronavirus 2 (COVID-19) , 2020, Scientific Reports.