Identification of a multixenobiotic resistance mechanism in primary cultured epidermal cells from Oncorhynchus mykiss and the effects of environmental complex mixtures on its activity.

[1]  C. Mothersill,et al.  An assessment of the pollutant status of surficial sediment in Cork Harbour in the South East of Ireland with particular reference to polycyclic aromatic hydrocarbons. , 2004, Marine pollution bulletin.

[2]  C. Mothersill,et al.  Ionizing Radiation Induces a Stress Response in Primary Cultures of Rainbow Trout Skin , 2004, Radiation research.

[3]  A. Koehler,et al.  Regulation of expression of multixenobiotic resistance (MXR) genes by environmental factors in the blue mussel Mytilus edulis. , 2004, Aquatic toxicology.

[4]  B. Jackson,et al.  Responses of benthic fish exposed to contaminants in outdoor microcosms--examining the ecological relevance of previous laboratory toxicity tests. , 2004, Aquatic toxicology.

[5]  A. Boudou,et al.  Induction of a multixenobiotic resistance protein (MXR) in the Asiatic clam Corbicula fluminea after heavy metals exposure. , 2004, Aquatic toxicology.

[6]  C. Mothersill,et al.  The differential effects of cadmium exposure on the growth and survival of primary and established cells from fish and mammals , 1996, Cell Biology and Toxicology.

[7]  B. Hackenberger,et al.  Inducibility of the P-glycoprotein transport activity in the marine mussel Mytilus galloprovincialis and the freshwater mussel Dreissena polymorpha. , 2003, Aquatic toxicology.

[8]  J. Stegeman,et al.  Expression of P-glycoprotein and cytochrome p450 1A in intertidal fish (Anoplarchus purpurescens) exposed to environmental contaminants. , 2002, Aquatic toxicology.

[9]  C. Mothersill,et al.  Rainbow trout primary epidermal cell proliferation as an indicator of aquatic toxicity: an in vitro/in vivo exposure comparison. , 2002, Aquatic toxicology.

[10]  M. E. Hahn,et al.  Expression of P-glycoprotein in killifish (Fundulus heteroclitus) exposed to environmental xenobiotics. , 2002, Aquatic toxicology.

[11]  T. Smital,et al.  Measurement of the activity of multixenobiotic resistance mechanism in the common carp Cyprinus carpio. , 2002, Marine environmental research.

[12]  F. Leboulenger,et al.  Genetic and immunological characterisation of a multixenobiotic resistance system in the turbot (Scophthalmus maximus). , 2002, Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology.

[13]  H. Segner,et al.  Expression and functional activity of P-glycoprotein in cultured hepatocytes fromOncorhynchus mykiss , 2001 .

[14]  J. Cravedi,et al.  Prochloraz and nonylphenol diethoxylate inhibit an mdr1-like activity in vitro, but do not alter hepatic levels of P-glycoprotein in trout exposed in vivo. , 2001, Aquatic toxicology.

[15]  C. Mothersill,et al.  The further development of rainbow trout primary epithelial cell cultures as a diagnostic tool in ecotoxicology risk assessment. , 2001, Aquatic toxicology.

[16]  Olaf van Tellingen,et al.  The importance of drug-transporting P-glycoproteins in toxicology. , 2001 .

[17]  C. Mothersill,et al.  Heat shock protein 70 levels in rainbow trout primary epidermal cultures in response to 2,4‐dichloroaniline exposure: A novel in vitro aquatic toxicity marker , 2001, Environmental toxicology.

[18]  H. Segner,et al.  Expression and functional activity of P-glycoprotein in cultured hepatocytes from Oncorhynchus mykiss. , 2001, American journal of physiology. Regulatory, integrative and comparative physiology.

[19]  J. Albertus,et al.  Enhanced xenobiotic transporter expression in normal teleost hepatocytes: response to environmental and chemotherapeutic toxins. , 2001, The Journal of experimental biology.

[20]  C. Mothersill,et al.  An in vitro assessment of the toxicity of 2,4‐dichloroaniline using rainbow trout primary epidermal cell cultures , 2000 .

[21]  A. Doi,et al.  Multixenobiotic resistance mechanism in the catfish intestine , 2000 .

[22]  Bard,et al.  Multixenobiotic resistance as a cellular defense mechanism in aquatic organisms. , 2000, Aquatic toxicology.

[23]  J. O’Halloran,et al.  Acute and sublethal toxicity of estuarine sediments to the Manila clam, Tapes semidecussatus , 2000 .

[24]  Proceedings of the 10th International Symposium on Pollutant Responses in Marine Organisms (PRIMO 10). Williamsburg, Virginia, USA. 25-29 April 1999. , 2000, Marine environmental research.

[25]  C. Mothersill,et al.  Use of rainbow trout primary epidermal cell cultures as an alternative to immortalized cell lines in toxicity assessment: A study with nonoxynol , 1999 .

[26]  P. Cooper,et al.  Altered expression of the xenobiotic transporter P-glycoprotein in liver and liver tumours of mummichog Fundulus heteroclitus from a creosote-contaminated environment. , 1999, Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals.

[27]  Christophe Minier Nancy Eufemia David Epel.  The multi-xenobiotic resistance phenotype as a tool to biomonitor the environment. , 1999, Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals.

[28]  P. Roepe,et al.  The P-Glycoprotein Efflux Pump: How Does it Transport Drugs? , 1998, The Journal of Membrane Biology.

[29]  A. Köhler,et al.  Clonal adaptation of cancer cells in flatfish liver to environmental contamination by changes in expression of P-gp related MXR, CYP450, GST-A and G6PDH activity , 1998 .

[30]  B. Kurelec,et al.  Fragility of multixenobiotic resistance in aquatic organisms enhances the complexity of risk assessment , 1998 .

[31]  W. Benson,et al.  Comparison of three histological fixatives on the immunoreactivity of mammalian P-glycoprotein antibodies in the sheepshead minnow, Cyprinodon variegatus. , 1998, The Journal of experimental zoology.

[32]  B. Kurelec,et al.  The chemosensitizers of multixenobiotic resistance mechanism in aquatic invertebrates: a new class of pollutants. , 1998, Mutation research.

[33]  C. Mothersill,et al.  The effects of cadmium exposure on the cytology and function of primary cultures from rainbow trout , 1998, Cell biochemistry and function.

[34]  C. Higgins,et al.  A divergent CFTR homologue: highly regulated salt transport in the euryhaline teleost F. heteroclitus. , 1998, American journal of physiology. Cell physiology.

[35]  L. Bain,et al.  Interaction of structurally diverse pesticides with the human MDR1 gene product P-glycoprotein. , 1996, Toxicology and applied pharmacology.

[36]  Colleen M. Elonen,et al.  A physiologically based toxicokinetic model for dermal absorption of organic chemicals by fish. , 1996, Fundamental and applied toxicology : official journal of the Society of Toxicology.

[37]  U. Germann,et al.  P-glycoprotein--a mediator of multidrug resistance in tumour cells. , 1996, European journal of cancer.

[38]  Michael N Moore,et al.  Induction of multixenobiotic resistance in mussel blood cells , 1996 .

[39]  Y. Assaraf,et al.  The Role of Passive Transbilayer Drug Movement in Multidrug Resistance and Its Modulation* , 1996, The Journal of Biological Chemistry.

[40]  B. Kurelec.  Inhibition of multixenobiotic resistance mechanism in aquatic organisms: ecotoxic consequences , 1995 .

[41]  Holly M. Brown-Borg,et al.  Culture of Animal Cells: A Manual of Basic Technique, R. Ian Freshney (Ed.). Wiley-Liss, Inc., New York (1994) , 1995 .

[42]  C. Mothersill,et al.  Growth and differentiation of epidermal cells from the rainbow trout established as explants and maintained in various media , 1995 .

[43]  L. Ortego,et al.  Immunohistochemical detection of P-glycoprotein in teleost tissues using mammalian polyclonal and monoclonal antibodies. , 1995, The Journal of experimental zoology.

[44]  W. Jarman,et al.  Characterization of multixenobiotic/multidrug transport in the gills of the mussel Mytilus californianus and identification of environmental substrates , 1995 .

[45]  D. Miller,et al.  P-glycoprotein-mediated secretion of a fluorescent cyclosporin analogue by teleost renal proximal tubules. , 1995, The American journal of physiology.

[46]  E. Santoni-Rugiu,et al.  Differential modulation of P-glycoprotein expression by dexamethasone and 3-methylcholanthrene in rat hepatocyte primary cultures. , 1994, Carcinogenesis.

[47]  D. Epel,et al.  Multixenobiotic Resistance in Urechis caupo Embryos: Protection From Environmental Toxins. , 1993, The Biological bulletin.

[48]  B. Kurelec.  The multixenobiotic resistance mechanism in aquatic organisms. , 2002, Critical reviews in toxicology.

[49]  V. Ling,et al.  P-glycoprotein genes in the winter flounder, Pleuronectes americanus: isolation of two types of genomic clones carrying 3' terminal exons. , 1992, Biochimica et biophysica acta.

[50]  R. Weinstein.  Advances in Pathology and Laboratory Medicine , 1992 .

[51]  D. Loring,et al.  Manual for the geochemical analyses of marine sediments and suspended particulate matter , 1992 .

[52]  J. M. Ford,et al.  Pharmacology of drugs that alter multidrug resistance in cancer. , 1990, Pharmacological reviews.

[53]  I. Pastan,et al.  Heat shock and arsenite increase expression of the multidrug resistance (MDR1) gene in human renal carcinoma cells. , 1990, The Journal of biological chemistry.

[54]  J. Mitsuhashi.  Invertebrate Cell System Applications , 1989 .

[55]  J. Bulte,et al.  Monoclonal antibody JSB‐1 detects a highly conserved epitope on the P‐glycoprotein associated with multi‐drug‐resistance , 1988, International journal of cancer.

[56]  R. Ian Freshney,et al.  Culture of Animal Cells: A Manual of Basic Technique and Specialized Applications , 2010 .

[57]  J. Raa,et al.  Skin mucus protease from rainbow trout, Salmo gairdneri Richardson, and its biological significance , 1983 .

[58]  R. Engler,et al.  Dredged Material Research Program. , 1977 .

[59]  R L Juliano,et al.  A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants. , 1976, Biochimica et biophysica acta.

[60]  L. Harrell,et al.  Humoral factors important in resistance of salmonid fish to bacterial disease.II.Anti-Vibrio anguillarum activity in mucus and observations on complement , 1976 .

[61]  R. Berliner,et al.  Carbonic anhydrase inhibitors. , 1956, Pharmacological reviews.