THE EFFECTS OF PANCREATECTOMY ON GLYCOSURIA AND KETOSIS IN DOGS MADE DIABETIC BY ALLOXAN1

FOLLOWING the experiments of Dunn, Sheehan, and McLetchie (1943,a) demonstrating that alloxan was capable of producing necrosis of the islets of Langerhans in rabbits, it became evident that this substance could be used for the production of permanent experimental diabetes in several species (Dunn, Sheehan, and McLetchie; 1943,b; Bailey and Bailey, 1943; Goldner and Gomori, 1943). Of particular interest was the work carried out on dogs (Goldner and Gomori, 1943), since the metabolic state which resulted from alloxan administration was found to be associated with a histological picture of selective necrosis of the beta cells without damage to the other components of the islet or acinar tissue. Moreover the hyperglycemia and hyper-lipemia in these dogs was considered by the authors to be even more severe than that usually seen in pancreatectomized animals, and, although the suggestion was made that this difference was the result of the drug's toxic action on the liver, it seems paradoxical that, in the abse...