论文信息 - Focal Adhesion Kinase as a Cellular Mechano-Sensor

Focal Adhesion Kinase as a Cellular Mechano-Sensor

Focal adhesion kinase (FAK) is a component of focal adhesion sites, which plays a crucial role in cell differentiation and motility. Using molecular dynamic simulations, we observed that binding of the phospho-inositide phosphatidylinositol-4,5-bisphosphate (\(\mathit{PIP}_{2}\)) by FAK can induce major conformational changes of FAK and exposure of its auto-phosphorylation site, but it cannot induce FAK’s activation. Our results support the biological experimental data by providing an atomic description of FAK’s conformational changes within FERM and kinase domains.

Jing Zhou | Agnieszka Bronowska | Frauke Gräter | Bogdan Costescu

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