L-Proline catalyzed asymmetric aldol reactions of protected hydroxyacetone

We extended the proline-catalyzed asymmetric direct aldol reactions to the TBDMS protected hydroxyacetone. This important donor provides a ready access to optically active monoprotected 1,2-diol units simultaneously accompanied by stereoselective carbon-carbon bond formation in 40–90% yield and in up to 95% ee.

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