ABSORPTION OF ANTIBACTERIAL AGENTS BY THE BOVINE

The morphology of bovine lymphocytes in normal, inflammatory and neoplastic states. V. E. 0. Valli, J. H. Lumsden, M. E. Smart, H. H. Grenn and B. J. McSherry (Dept. Path., Ont. Vet. Coll., Guelph, Ontario). The hematologic diagnosis of bovine lymphosarcoma is largely based on the total lymphocyte count in peripheral blood. The purpose of this study was to determine if the morphology of lymphocytes differed significantly between inflammatory and neoplastic states and if these differences could be used to distinguish between reactive lymphocytosis and lymphoid leukemia. In addition the morphology of the neutrophils in normal, inflammatory and neoplastic states were studied to determine if malignancy associated changes occurred in the neutrophils of cattle with lymphosarcoma. Blood smears were examined from four groups of 25 cows: 1) Cows with lymphosarcoma proven at necropsy, 2) Cows with non-neoplastic diseases proven at necropsy, 3) Cows with lymphocytosis or believed to have subelinical lymphosarcoma and 4) Normal mature cows sent for slaughter. The blood smears were coded and examined blindly by five of the authors for malignancy associated chanegs in the granulocytes and malignant changes in the lymphocytes. Statistical evaluation of these results showed that malignant lymphocytes could be identified morphologically with a high degree of ac-

[1]  I.U.I. an indwelling device for infusion of the bovine uterus. , 1970, Veterinary medicine, small animal clinician : VM, SAC.

[2]  J. Sutter,et al.  Improved method for determination of sulfonamides in milk and tissues , 1968 .

[3]  W. O. Crutchfield.  A technic for placement of an indwelling catheter in the cow. , 1968, Veterinary medicine, small animal clinician : VM, SAC.

[4]  C. M. Stowe,et al.  Drug Movement between Bovine Milk and Plasma as Affected by Milk pH , 1967 .

[5]  C. M. Stowe,et al.  Diffusion of certain weak organic acids and bases across the bovine mammary gland membrane after systemic administration. , 1967, The Journal of pharmacology and experimental therapeutics.

[6]  C. M. Stowe,et al.  Influence of oxytocin on diffusion of sulfonamides from plasma into bovine milk. , 1967, Journal of dairy science.

[7]  F. Rasmussen.  Studies on the mammary excretion and absorption of drugs , 1966 .

[8]  C. M. Stowe,et al.  THE MECHANISM OF DRUG SECRETION INTO BOVINE MILK , 1964, Annals of the New York Academy of Sciences.

[9]  C. M. Stowe,et al.  Mechanism of secretion of sulfonamides into bovine milk. , 1964, Proceedings, annual meeting of the United States Animal Health Association.

[10]  F. Rasmussen.  Mammary Excretion of Antipyrine, Ethanol, and Urea , 1961, Acta Veterinaria Scandinavica.

[11]  A. Pier,et al.  Antibiotic levels in milk following intrauterine infusion. , 1960 .

[12]  F. Rasmussen.  Mammary excretion of benzylpenicillin, erythromycin, and penethamate hydroiodide. , 2009, Acta pharmacologica et toxicologica.

[13]  C. Bierschwal,et al.  The absorption of chlortetracycline (aureomycin) by the bovine uterus. , 1956, Journal of the American Veterinary Medical Association.

[14]  C. Bierschwal,et al.  The absorption of sulfamethazine by the bovine uterus. , 1955, Journal of the American Veterinary Medical Association.