Design, Synthesis and SAR Study of Novel Trisubstituted Pyrimidine Amide Derivatives as CCR4 Antagonists
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Jun-hai Xiao | Song Li | Xiaohong Yang | Li-li Wang | Dan Jiang | Yang Zhang | Ying Wang | L. Xu | Wenjie Dai
[1] Qi Hui,et al. Design,Synthesis and Biological Activities of a Series of Piperazine Pyrimidine as CCR4 Antagonists , 2013 .
[2] A. Asai,et al. Internalization of CCR4 and Inhibition of Chemotaxis by K777, a Potent and Selective CCR4 Antagonist , 2013, Pharmacology.
[3] W. A. Yeudall,et al. Chemokines, chemokine receptors and the gastrointestinal system. , 2013, World journal of gastroenterology.
[4] D. Greaves,et al. CC Chemokine Receptors and Chronic Inflammation—Therapeutic Opportunities and Pharmacological Challenges , 2013, Pharmacological Reviews.
[5] Hongwei Gong,et al. Design and Synthesis of a Series of Pyrido[2,3-d]pyrimidine Derivatives as CCR4 Antagonists , 2012, Molecules.
[6] S. Hodgson,et al. Lead optimisation of the N1 substituent of a novel series of indazole arylsulfonamides as CCR4 antagonists and identification of a candidate for clinical investigation. , 2012, Bioorganic & medicinal chemistry letters.
[7] R. Leurs,et al. Pharmacological modulation of chemokine receptor function , 2012, British journal of pharmacology.
[8] P. Workman,et al. Preparation and evaluation of trisubstituted pyrimidines as phosphatidylinositol 3-kinase inhibitors. 3-Hydroxyphenol analogues and bioisosteric replacements. , 2011, Bioorganic & medicinal chemistry.
[9] M. Yamashita,et al. RS-1748, a novel CC chemokine receptor 4 antagonist, inhibits ovalbumin-induced airway inflammation in guinea pigs. , 2010, Biological & pharmaceutical bulletin.
[10] P. Howarth,et al. Chemokine Receptor 4 Plays a Key Role in T Cell Recruitment into the Airways of Asthmatic Patients , 2010, The Journal of Immunology.
[11] J. Clardy,et al. Synthesis and antiplasmodial activity of novel 2,4-diaminopyrimidines. , 2010, Bioorganic & medicinal chemistry letters.
[12] A. Viola,et al. Chemokines and their receptors: drug targets in immunity and inflammation. , 2008, Annual review of pharmacology and toxicology.
[13] K. McIntyre,et al. Core exploration in optimization of chemokine receptor CCR4 antagonists. , 2007, Bioorganic & medicinal chemistry letters.
[14] A. Purandare,et al. Antagonists of CCR4 as immunomodulatory agents. , 2006, Current topics in medicinal chemistry.
[15] J. Wityak,et al. Identification of chemokine receptor CCR4 antagonist. , 2005, Bioorganic & medicinal chemistry letters.
[16] A. Proudfoot. Chemokine receptors: multifaceted therapeutic targets , 2002, Nature Reviews Immunology.
[17] R. Pawankar,et al. Inducible Expression of a Th2-Type CC Chemokine Thymus- and Activation-Regulated Chemokine by Human Bronchial Epithelial Cells1 , 2000, The Journal of Immunology.
[18] A. Wagner,et al. Efficient and Regioselective 4‐Amino‐de‐chlorination of 2,4,6‐Trichloropyrimidine with N‐Sodium Carbamates. , 2000 .
[19] P. Allavena,et al. Differential Expression of Chemokine Receptors and Chemotactic Responsiveness of Type 1 T Helper Cells (Th1s) and Th2s , 1998, The Journal of experimental medicine.
[20] S. Fricker,et al. Chemokine receptor modeling: an interdisciplinary approach to drug design. , 2014, Future medicinal chemistry.