The hygiene hypothesis: an evolutionary perspective.

[1]  N. Bresolin,et al.  The role of protozoa-driven selection in shaping human genetic variability. , 2010, Trends in genetics : TIG.

[2]  Matteo Fumagalli,et al.  Genome-Wide Identification of Susceptibility Alleles for Viral Infections through a Population Genetics Approach , 2010, PLoS genetics.

[3]  Jeremiah D. Degenhardt,et al.  Targets of balancing selection in the human genome. , 2009, Molecular biology and evolution.

[4]  Atul J. Butte,et al.  Autoimmune Disease Classification by Inverse Association with SNP Alleles , 2009, PLoS genetics.

[5]  S. Sakaguchi,et al.  Regulatory T cells: how do they suppress immune responses? , 2009, International immunology.

[6]  Y. Shoenfeld,et al.  Infections and autoimmunity--friends or foes? , 2009, Trends in immunology.

[7]  Joseph K. Pickrell,et al.  Evolutionary Dynamics of Human Toll-Like Receptors and Their Different Contributions to Host Defense , 2009, PLoS genetics.

[8]  Matteo Fumagalli,et al.  Parasites represent a major selective force for interleukin genes and shape the genetic predisposition to autoimmune conditions , 2009, The Journal of experimental medicine.

[9]  M. Jenmalm,et al.  Altered early infant gut microbiota in children developing allergy up to 5 years of age , 2009, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

[10]  L. Lynd,et al.  Antibiotic Use in Children Is Associated With Increased Risk of Asthma , 2009, Pediatrics.

[11]  G. Rook Review series on helminths, immune modulation and the hygiene hypothesis: The broader implications of the hygiene hypothesis , 2009, Immunology.

[12]  J. Bradley,et al.  Review series on helminths, immune modulation and the hygiene hypothesis: Immunity against helminths and immunological phenomena in modern human populations: coevolutionary legacies? , 2009, Immunology.

[13]  B. Roe,et al.  A core gut microbiome in obese and lean twins , 2008, Nature.

[14]  R Balfour Sartor,et al.  Specific microbiota direct the differentiation of IL-17-producing T-helper cells in the mucosa of the small intestine. , 2008, Cell host & microbe.

[15]  N. Bresolin,et al.  The signature of long-standing balancing selection at the human defensin β-1 promoter , 2008, Genome Biology.

[16]  R. Ley,et al.  Innate immunity and intestinal microbiota in the development of Type 1 diabetes , 2008, Nature.

[17]  R. Nielsen,et al.  Patterns of Positive Selection in Six Mammalian Genomes , 2008, PLoS genetics.

[18]  T. Marquès-Bonet,et al.  Balancing Selection Is the Main Force Shaping the Evolution of Innate Immunity Genes1 , 2008, The Journal of Immunology.

[19]  Peter J Hotez,et al.  Helminth infections: the great neglected tropical diseases. , 2008, The Journal of clinical investigation.

[20]  C. Lowry,et al.  The hygiene hypothesis and psychiatric disorders. , 2008, Trends in immunology.

[21]  David S Sanders,et al.  Newly identified genetic risk variants for celiac disease related to the immune response , 2008, Nature Genetics.

[22]  J. Gordon,et al.  IgA response to symbiotic bacteria as a mediator of gut homeostasis. , 2007, Cell host & microbe.

[23]  D. Relman,et al.  An ecological and evolutionary perspective on human–microbe mutualism and disease , 2007, Nature.

[24]  N. Pace,et al.  Molecular-phylogenetic characterization of microbial community imbalances in human inflammatory bowel diseases , 2007, Proceedings of the National Academy of Sciences.

[25]  H. Renz,et al.  Epidemiological and immunological evidence for the hygiene hypothesis. , 2007, Immunobiology.

[26]  Pierre Ernst,et al.  Increased risk of childhood asthma from antibiotic use in early life. , 2007, Chest.

[27]  Nathan D. Wolfe,et al.  Origins of major human infectious diseases , 2007, Nature.

[28]  D. Penn,et al.  Murine scent mark microbial communities are genetically determined. , 2007, FEMS microbiology ecology.

[29]  M. McFall-Ngai Adaptive Immunity: Care for the community , 2007, Nature.

[30]  D. Vercelli Mechanisms of the hygiene hypothesis--molecular and otherwise. , 2006, Current opinion in immunology.

[31]  P. A. van den Brandt,et al.  Factors Influencing the Composition of the Intestinal Microbiota in Early Infancy , 2006, Pediatrics.

[32]  L. Shek,et al.  Distinct Pattern of Commensal Gut Microbiota in Toddlers with Eczema , 2006, International Archives of Allergy and Immunology.

[33]  J. Pritchard,et al.  A Map of Recent Positive Selection in the Human Genome , 2006, PLoS biology.

[34]  R. Ley,et al.  Ecological and Evolutionary Forces Shaping Microbial Diversity in the Human Intestine , 2006, Cell.

[35]  Pierre Baldi,et al.  Global landscape of recent inferred Darwinian selection for Homo sapiens , 2006, Proc. Natl. Acad. Sci. USA.

[36]  A. Murray,et al.  Investigations into the influence of host genetics on the predominant eubacteria in the faecal microflora of children. , 2005, Journal of medical microbiology.

[37]  N. Bresolin,et al.  Analysis of intronic conserved elements indicates that functional complexity might represent a major source of negative selection on non-coding sequences. , 2005, Human molecular genetics.

[38]  N. Saitou,et al.  Evidence for natural selection in the HAVCR1 gene: high degree of amino-acid variability in the mucin domain of human HAVCR1 protein , 2005, Genes and Immunity.

[39]  S. Mazmanian,et al.  An Immunomodulatory Molecule of Symbiotic Bacteria Directs Maturation of the Host Immune System , 2005, Cell.

[40]  F. Obermeier,et al.  Influence of intestinal bacteria on induction of regulatory T cells: lessons from a transfer model of colitis , 2005, Gut.

[41]  F. Balloux,et al.  Pathogen-Driven Selection and Worldwide HLA Class I Diversity , 2005, Current Biology.

[42]  J. Epplen,et al.  The genetics of atopic dermatitis: recent findings and future options , 2005, Journal of Molecular Medicine.

[43]  A. Cooke,et al.  A worm's eye view of the immune system: consequences for evolution of human autoimmune disease , 2005, Nature Reviews Immunology.

[44]  R. Maizels,et al.  Helminth parasites – masters of regulation , 2004, Immunological reviews.

[45]  Fyodor A Kondrashov,et al.  The functional genomic distribution of protein divergence in two animal phyla: coevolution, genomic conflict, and constraint. , 2004, Genome research.

[46]  Rosalind J Wright,et al.  Day care attendance in early life, maternal history of asthma, and asthma at the age of 6 years. , 2003, American journal of respiratory and critical care medicine.

[47]  Y. Narisawa,et al.  Differences in fecal microflora between patients with atopic dermatitis and healthy control subjects. , 2003, The Journal of allergy and clinical immunology.

[48]  R. Lemanske The Childhood Origins of Asthma (COAST) study , 2002, Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology.

[49]  Keiichiro Suzuki,et al.  Critical Roles of Activation-Induced Cytidine Deaminase in the Homeostasis of Gut Flora , 2002, Science.

[50]  J. Bach,et al.  The effect of infections on susceptibility to autoimmune and allergic diseases. , 2002, The New England journal of medicine.

[51]  D. Nowak,et al.  Environmental exposure to endotoxin and its relation to asthma in school-age children. , 2002, The New England journal of medicine.

[52]  Dennis Nowak,et al.  Exposure to farming in early life and development of asthma and allergy: a cross-sectional survey , 2001, The Lancet.

[53]  Willem M. de Vos,et al.  The Host Genotype Affects the Bacterial Community in the Human Gastrointestinal Tract , 2001 .

[54]  P. Toivanen,et al.  Influence of Major Histocompatibility Complex on Bacterial Composition of Fecal Flora , 2001, Infection and Immunity.

[55]  E. Zoetendal,et al.  The Host Genotype Affects the Bacterial Community in the Human Gastronintestinal Tract , 2001 .

[56]  J. Casanova,et al.  Clinical consequences of defects in the IL‐12‐dependent interferon‐gamma (IFN‐γ) pathway , 2000, Clinical and experimental immunology.

[57]  J Lederberg,et al.  Infectious History , 2000, Science.

[58]  C. Kapp WHO warns of microbial threat , 1999, The Lancet.

[59]  D. Strachan Allergy and family size: a riddle worth solving , 1997, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

[60]  M. Clerici,et al.  Type 1 and type 2 cytokine dysregulation in human infectious, neoplastic, and inflammatory diseases , 1996, Clinical microbiology reviews.

[61]  P. Howarth,et al.  T-cell cytokine profile evaluated at the single cell level in BAL and blood in allergic asthma. , 1996, American journal of respiratory cell and molecular biology.

[62]  R. Martin,et al.  The Cambridge encyclopedia of human evolution , 1994 .

[63]  D. P. Strachan,et al.  Hay fever, hygiene, and household size. , 1989, BMJ.

[64]  C. Weston,et al.  Hay Fever , 1885, The Journal of the Medical Society of New Jersey.

[65]  L. Quintana-Murci,et al.  From evolutionary genetics to human immunology: how selection shapes host defence genes , 2010, Nature Reviews Genetics.

[66]  N. Bresolin,et al.  Widespread balancing selection and pathogen-driven selection at blood group antigen genes. , 2009, Genome research.

[67]  R. Knight,et al.  Worlds within worlds: evolution of the vertebrate gut microbiota , 2008, Nature Reviews Microbiology.

[68]  J. Casanova,et al.  Inborn errors of immunity to infection: the rule rather than the exception , 2005 .

[69]  N. Risch,et al.  Hepatitis A virus link to atopic disease , 2003 .