In silico approaches to microarray-based disease classification and gene function discovery

The automated analysis of transcriptional profiling data promises a wealth of information that may be used to develop a more complete understanding of gene function and interactions. Moreover, it may improve the effectiveness of complex diagnostic tasks. This article discusses important data mining and management techniques to analyse genome-wide expression data. It reviews some of the major discovery goals, methods and applications in a number of biomedical domains. Finally, this paper highlights key problems that need to be approached by a new generation of computational solutions.

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