Synthesis and chemotherapeutic effects of ethyl bis-(2,2-dimethyl)-ethylenamido phosphate. A preliminary report.

The title compound, a new analog of the experimental anticancer agent, AB-132, was synthesized and tested against a spectrum of transplanted animal tumors. It was found to have significant chemotherapeutic activity in all of the tumor systems studied. In these assays, the new compound was a much more effective antitumor agent than AB-132.