Synthesis and chemotherapeutic effects of ethyl bis-(2,2-dimethyl)-ethylenamido phosphate. A preliminary report.
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The title compound, a new analog of the experimental anticancer agent, AB-132, was synthesized and tested against a spectrum of transplanted animal tumors. It was found to have significant chemotherapeutic activity in all of the tumor systems studied. In these assays, the new compound was a much more effective antitumor agent than AB-132.
[1] D. Triggle,et al. A STUDY OF COMPARATIVE CHEMICAL AND BIOLOGICAL ACTIVITIES OF ALKYLATING AGENTS. , 1965, Journal of medicinal chemistry.
[2] T. Bardos,et al. SYNTHESIS OF POTENTIAL DUAL ANTAGONISTS. 3. RING-SUBSTITUTED ETHYL (BIS(1-AZIRIDINYL)PHOSPHINYL)CARBAMATES. , 1965, Journal of pharmaceutical sciences.
[3] J. Webster,et al. Combined use of AB‐132 (Meturedepa, Turloc) and X irradiation in the management of advanced bronchogenic carcinoma , 1964, Cancer.