Analysis of drugs by microcalorimetry Isothermal power-conduction calorimetry and thermometric titrimetry.

Microcalorimetric analysis has been the subject of a few review's in recent years, but these reviews have mainly dealt with the wide-ranging capabilities of calorimetric assay. This review, however, discusses the experimental basis and practical exploitation of the method in the particularly important area of pharmaceuticals. This field of analysis embraces both conventional chemical assays and bioassays which involve living microbial species. The review highlights the design of calorimetric instruments appropriate for study of microbial metabolism and interaction with drug substances. For comprehensiveness, both microcalorimetric and thermometric assay systems are discussed and critically assessed.

[1]  C. Bjurulf.  Calorimetric titration of lysozyme. , 1972, European journal of biochemistry.

[2]  H. Schäfer,et al.  Die Bestimmung von Sulfonsäure-Amiden durch thermometrische Titration mit Hypochlorit , 1950 .

[3]  V. Vajgand,et al.  Catalytic thermometric titrations in non-aqueous solvents by coulometrically generated titrant. , 1970, Talanta.

[4]  G. Hardee,et al.  Microcalorimetric investigations of pharmaceutical complexes II. Drug-albumin interactions. , 1978, Biochemical pharmacology.

[5]  N. Malingerová,et al.  Enthalpimetric determinations with sodium hypobromit , 1978 .

[6]  L. Bark,et al.  N-Bromosuccinimide as a redox titrant in thermometric titrimetry , 1976 .

[7]  L. Bark,et al.  Assay of some physiologically active alkaloids by thermometric titrimetry , 1973 .

[8]  E. J. Greenhow.  Acetylation as a means of end-point indication in the catalytic thermometric titration of bases , 1977 .

[9]  L. E. Spencer,et al.  Ionic polymerisation as a means of end-point indication in non-aqueous thermometric titrimetry. Part V. The iodimetric determination of organic bases, hydrazine derivatives and water , 1974 .

[10]  P. Privalov.  Scanning microcalorimeters for studying macromolecules , 1980 .

[11]  J. Jordan,et al.  Direct Enthalpimetry. A New Thermochemical Approach to Quantitative Analysis. , 1964 .

[12]  A. Beezer,et al.  Bioassay of nystatin: measurement of Mg2+ efflux by atomic-absorption spectroscopy. , 1979, Talanta.

[13]  N. Langerman,et al.  An improved method for obtaining thermal titration curves using micromolar quantities of protein. , 1978, Analytical biochemistry.

[14]  V. Vajgand,et al.  Determination of organic bases in non-aqueous solvents by catalytic thermometric titration. , 1968, Talanta.

[15]  H. Mottola.  Catalytic titrants and catalytic indication of end-points. , 1969, Talanta.

[16]  I. Wadsö,et al.  A calorimetric study of the chymotrypsinogen family of proteins. , 1971, Biochemistry.

[17]  L. Bark,et al.  A rapid method for the assay of ascorbic acid tablets. , 1975, The Analyst.

[18]  J. Jordan,et al.  Enzymatic enthalpimetry, a new approach to clinical analysis: Glucose determination by hexokinase catalyzed phosphorylation. , 1975, Analytical chemistry.

[19]  L. Bark,et al.  Enthalpimetric determination of nitrogen-containing bases , 1972 .

[20]  A. Beezer,et al.  Application of flow microcalorimetry to analytical problems: the preparation, storage and assay of frozen inocula of Saccharomyces cerevisiae. , 1976, The Journal of applied bacteriology.

[21]  L. Bark,et al.  Thermometric assay of some sulphonamides of pharmaceutical importance. , 1973, The Analyst.

[22]  P. Carr,et al.  Rapid and precise determination of total serum protein by thermochemical analysis. , 1973, Analytical chemistry.

[23]  L. E. Spencer,et al.  Ionic polymerisation as a means of end-point indication in non-aqueous thermometric titrimetry. 3. The determination of alkaloids and alkaloidal salts. , 1973, The Analyst.

[24]  L. Bark,et al.  Catalymetric - thermometric titration of some derivatives of barbituric acid. , 1976, In Analysis.

[25]  V. Vajgand,et al.  Determination of tertiary amines and salts of organic acids in acetic acid by catalytic thermometric titration. , 1967, Talanta.

[26]  M. Mäki,et al.  In Vitro Studies of Amphotericin B in Combination with the Imidazole Antifungal Compounds Clotrimazole and Miconazole , 1978 .

[27]  A. Thomas,et al.  Assay of nystatin based on the measurement of potassium released from Saccharomyces serevisiae. , 1977, The Analyst.

[28]  L. E. Spencer,et al.  Acetaldehyde as an end-point indicator in the catalytic thermometric titration of weak acids. , 1977, Talanta.

[29]  A. Beezer,et al.  Bioassay of antifungal antibiotics by flow microcalorimetry. , 1977, Analytical chemistry.

[30]  E. J. Greenhow,et al.  Ionic polymerisation as a means of end-point indication in non-aqueous thermometric titrimetry. Part VIII. Solvent effects in the determination of polyfunctional carboxylic acids and phenols , 1976 .

[31]  L. Bark,et al.  The thermometric assay of ascorbic acid. , 1974, The Analyst.

[32]  W. E. Jensen,et al.  Influence of cytotoxic agents on thermogenesis in streptococcus faecalis , 1976 .

[33]  L. Bark,et al.  An investigation of the potential uses of iodine monochloride as a titrant in thermometric titrimetry. , 1975, Talanta.

[34]  L. E. Spencer,et al.  Ionic polymerisation as a means of end-point indication in non-aqueous thermometric titrimetry. Part II. The determination of organic acids , 1973 .

[35]  B. Tan,et al.  The enthalpimetric determination of the Michaelis constant of the alpha-chymotrypsin-catalysed hydrolysis of N-acetyl-l-tyrosine ethyl ester based on the integrated Michaelis--Menten equation. , 1977, Analytica chimica acta.

[36]  A. Beezer,et al.  Bioassay of nystatin bulk material by flow microcalorimetry. , 1977, Analytical chemistry.

[37]  J. Burgot.  Dosages thermometriques de quelques substances a interet pharmaceutique derivees du noyau phenothiazine par une solution d'hydroxyde de sodium: Enthalpie de neutralisation, enthalpie et entropie d'ionisation du chlorhydrate de promethazine , 1978 .

[38]  Greenhow Ej,et al.  Ionic polymerisation as a means of end-point, indication in non-aqueous thermometric titrimetry. IV. The determination of catecholamines. , 1973 .

[39]  J. Jordan,et al.  Thermochemical determination of glucose in serum, plasma, and whole blood without prior deproteinization. , 1975, Clinical chemistry.

[40]  M. Stern,et al.  Applications of aqueous thermometric titration to pharmaceutical analysis. , 1966, Journal of Pharmacy and Science.

[41]  G. Vaughan,et al.  Acetone as solvent in the enthalpimetric titration of acidic substances , 1965 .

[42]  D. Eatough.  Recent progress in titration calorimetry , 1978 .

[43]  B. Danielsson,et al.  Determination of heat changes in the proximity of immobilised enzymes with an enzyme thermistor and its use for the assay of metabolites. , 1975, Biochimica et biophysica acta.

[44]  R. Biltonen,et al.  Calorimetric and potentiometric characterization of the ionization behavior of ribonuclease A and its complex with 3'-cytosine monophosphate. , 1975, Biochemistry.

[45]  L. E. Spencer,et al.  Determination of sulfonamides of pharmaceutical importance by catalytic thermometric titration. , 1975, Analytical chemistry.

[46]  J. Jordan,et al.  Letter: Enthalpimetric enzyme assay. , 1975, Analytical chemistry.

[47]  R. F. Selman,et al.  Continuous-flow enthalpimetry , 1965 .

[48]  R. M. Izatt,et al.  An Isothermal Titration Calorimeter , 1968 .

[49]  P. Carr,et al.  Rapid-flow enthalpimetric determination of urea in serum, with use of an immobilized urease reactor. , 1976, Clinical chemistry.

[50]  J. Brandštetr.  New instruments and methods for enthalpimetric analysis and calibration , 1978 .

[51]  P. Carr,et al.  An immobilized-enzyme flow-enthalpimetric analyzer: application to glucose determination by direct phosphorylation catalyzed by hexokinase. , 1976, Clinical chemistry.

[52]  B. Tan,et al.  The determination of some selected penicillins by enzymatic enthalpimetry , 1979 .

[53]  M. Stern,et al.  SOME POSSIBLE APPLICATIONS OF AQUEOUS THERMOMETRIC TITRATION TO PHARMACEUTICAL ANALYSIS. , 1964, Journal of pharmaceutical sciences.

[54]  D. Shiao,et al.  Heats of binding protons to globular proteins , 1976, Biopolymers.