Numerical simulation of volume‐controlled mechanical ventilated respiratory system with 2 different lungs

Mechanical ventilation is a key therapy for patients who cannot breathe adequately by themselves, and dynamics of mechanical ventilation system is of great significance for life support of patients. Recently, models of mechanical ventilated respiratory system with 1 lung are used to simulate the respiratory system of patients. However, humans have 2 lungs. When the respiratory characteristics of 2 lungs are different, a single-lung model cannot reflect real respiratory system. In this paper, to illustrate dynamic characteristics of mechanical ventilated respiratory system with 2 different lungs, we propose a mathematical model of mechanical ventilated respiratory system with 2 different lungs and conduct experiments to verify the model. Furthermore, we study the dynamics of mechanical ventilated respiratory system with 2 different lungs. This research study can be used for improving the efficiency and safety of volume-controlled mechanical ventilation system.

[1]  Fleur T. Tehrani,et al.  A control system for mechanical ventilation of passive and active subjects , 2013, Comput. Methods Programs Biomed..

[2]  F. Runovc,et al.  Simulation of pulmonary ventilation and its control by negative feedback , 2005, Comput. Biol. Medicine.

[3]  Grzegorz Redlarski,et al.  A new approach to modeling of selected human respiratory system diseases, directed to computer simulations , 2013, Comput. Biol. Medicine.

[4]  Guido Avanzolini,et al.  A new approach for tracking respiratory mechanical parameters in real-time , 2007, Annals of Biomedical Engineering.

[5]  John G. Eyles,et al.  Estimating Respiratory Mechanical Parameters in Parallel Compartment Models , 1981, IEEE Transactions on Biomedical Engineering.

[6]  Janusz Mroczka,et al.  Nonlinear model for mechanical ventilation of human lungs , 2006, Comput. Biol. Medicine.

[7]  Weiwei Yi,et al.  Design and realization of test bed for ventilation mode based on active servo lung: Design and realization of test bed for ventilation mode based on active servo lung , 2009 .

[8]  Agnaldo J Lopes,et al.  Changes in respiratory mechanics with increasing degrees of airway obstruction in COPD: detection by forced oscillation technique. , 2006, Respiratory medicine.

[9]  Hasan Guler,et al.  The comparison of manual and LabVIEW-based fuzzy control on mechanical ventilation , 2014, Proceedings of the Institution of Mechanical Engineers. Part H, Journal of engineering in medicine.

[10]  P. Behrakis,et al.  Volume and flow dependence of respiratory mechanics in mechanically ventilated COPD patients , 2003, Respiratory Physiology & Neurobiology.

[11]  Robin De Keyser,et al.  Assessment of respiratory mechanical properties with constant-phase models in healthy and COPD lungs , 2010, Comput. Methods Programs Biomed..

[12]  Bill Diong,et al.  Respiratory Impedance Values in Adults Are Relatively Insensitive to Mead Model Lung Compliance and Chest Wall Compliance Parameters , 2010 .

[13]  H. Nazeran,et al.  Can Asthma in Children be Detected by the Estimated Parameter Values of the Augmented RIC Model ? , 2006, 2006 International Conference of the IEEE Engineering in Medicine and Biology Society.