Study of Inhibitory Effect of Acidum Tranexamicum on Melanin Synthesis

Objective To observe the effect of acidum tranexamicum on melanogenesis of B16 melanoma cells and mechanism. Methods Colorimetry and immunohistochemistry were used to measure melanogenesis of B16 melanoma cells. Automatic amino acid analysis systemer and high performance liquid chromatography were used to evaluate the tyrosinase metabolism. Results Although acidum tranexamicum had no effect on proliferation and tyrosinase content of B16 melanoma cells, it can reduce melanogenesis of B16 melanoma cells and interfere the catalytic reaction of tyrosinase to tyrosine. Conclusion Acidum tranexamicum can inhibit melanogenesis by interfering catalytic reaction of tyrosinase .