The plasminogen receptor, Plg‐RKT, is essential for mammary lobuloalveolar development and lactation

Essentials Plg‐RKT‐/− female mice give birth, but no offspring of Plg‐RKT−/− female mice survive to weaning. Causal mechanisms of potential lactational failure in Plg‐RKT−/− mice are unknown. Plg‐RKT regulates extracellular matrix remodeling, cell proliferation, apoptosis, fibrin surveillance. Plg‐RKT is essential for lactogenesis and mammary lobuloalveolar development.

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