Single-Channel Bioimpedance Measurement for Wearable Continuous Blood Pressure Monitoring

Pulse transit time (PTT) sensing technology is rapidly evolving for cuffless continuous blood pressure (BP) monitoring. However, PTT-based BP methods must implement multidevices that could impede wearable applications. This work presents the study and development of a single-channel wrist-worn impedance plethysmography (IPG) system for wearable continuous BP measurement. IPG-based BP mathematical model with two-step calibration was derived for single physiological signal acquisition. The high-resolution IPG measurement was performed by optimized injection current frequency and electrode arrangement in response to obvious impedance difference between systolic BP (SBP) and diastolic BP (DBP) feature points in the IPG waveform, resulting in an impedance difference of 594 $\text{m}\Omega $ . The BP accuracy results within 30 subjects indicated that SBP estimation error was 2.01 ± 1.40 mmHg and 1.83 ± 1.29% in terms of mean absolute error (MAE) and mean absolute percentage error (MAPE), and 2.26 ± 1.43 mmHg and 4.96 ± 3.02% for DBP estimation. The novel system could potentially be implemented as a wearable cardiovascular monitoring device with two-in-one functions (continuous BP and heart rate monitoring) using a single physiological sensor in the future.

[1]  Yomna H. Shash,et al.  The effect of vascular diseases on bioimpedance measurements: mathematical modeling , 2018, Biomedical Research and Therapy.

[2]  Shing-Hong Liu,et al.  A Cuffless Blood Pressure Measurement Based on the Impedance Plethysmography Technique , 2017, Sensors.

[3]  Michelle Khine,et al.  Soft Wearable Pressure Sensors for Beat‐to‐Beat Blood Pressure Monitoring , 2019, Advanced healthcare materials.

[4]  Jefferson Luiz Brum Marques,et al.  Reflective Photoplethysmography Acquisition Platform With Monitoring Modules and Noninvasive Blood Pressure Calculation , 2020, IEEE Transactions on Instrumentation and Measurement.

[5]  Javier Reina-Tosina,et al.  Fundamentals, Recent Advances, and Future Challenges in Bioimpedance Devices for Healthcare Applications , 2019, J. Sensors.

[6]  Yuan-Ting Zhang,et al.  Continuous Blood Pressure Measurement From Invasive to Unobtrusive: Celebration of 200th Birth Anniversary of Carl Ludwig , 2016, IEEE J. Biomed. Health Informatics.

[7]  Weichih Hu,et al.  Development of forearm impedance plethysmography for the minimally invasive monitoring of cardiac pumping function , 2011 .

[8]  Mahdi Shabany,et al.  Cuffless Blood Pressure Estimation Algorithms for Continuous Health-Care Monitoring , 2017, IEEE Transactions on Biomedical Engineering.

[9]  Darrin J. Young,et al.  Skin-Coupled Personal Wearable Ambulatory Pulse Wave Velocity Monitoring System Using Microelectromechanical Sensors , 2014, IEEE Sensors Journal.

[10]  Hanns-Christian Gunga,et al.  Use of Bioelectrical Impedance: General Principles and Overview , 2012 .

[11]  Amirhossein Esmaili,et al.  Nonlinear Cuffless Blood Pressure Estimation of Healthy Subjects Using Pulse Transit Time and Arrival Time , 2017, IEEE Transactions on Instrumentation and Measurement.

[12]  Carles Aliau-Bonet,et al.  A Novel Method to Estimate Body Capacitance to Ground at Mid Frequencies , 2013, IEEE Transactions on Instrumentation and Measurement.

[13]  Roozbeh Jafari,et al.  Digital biomarkers for non-motor symptoms in Parkinson’s disease: the state of the art , 2019, IEEE Transactions on Biomedical Circuits and Systems.

[14]  Stefano Pisa,et al.  A virtual instrument for trans-thoracic impedance investigations , 2008 .

[15]  Bo Wen,et al.  Multi-Sensor Fusion Approach for Cuff-Less Blood Pressure Measurement , 2020, IEEE Journal of Biomedical and Health Informatics.

[16]  Solmaz Rastegar,et al.  Non-invasive continuous blood pressure monitoring systems: current and proposed technology issues and challenges , 2019, Physical and Engineering Sciences in Medicine.

[17]  B. Alpert,et al.  Oscillometric blood pressure: a review for clinicians. , 2014, Journal of the American Society of Hypertension : JASH.

[18]  Rajiv Kapoor,et al.  Electrical Bioimpedance: Methods and Applications , 2015, International Journal of Advance Research and Innovation.

[19]  Paul Annus,et al.  Methods for Detection of Bioimpedance Variations in Resource Constrained Environments , 2020, Sensors.

[20]  Peter Xiaoping Liu,et al.  Secondary Peak Detection of PPG Signal for Continuous Cuffless Arterial Blood Pressure Measurement , 2014, IEEE Transactions on Instrumentation and Measurement.

[21]  Mart Min,et al.  Lock-in measurement of bio-impedance variations , 2000 .

[22]  Tushar Kanti Bera,et al.  Bioelectrical Impedance Methods for Noninvasive Health Monitoring: A Review , 2014, Journal of medical engineering.

[23]  P. Annus,et al.  Noninvasive Acquisition of the Aortic Blood Pressure Waveform , 2019, Wearable Devices - the Big Wave of Innovation.

[24]  Jaakko Malmivuo,et al.  Sensitivity Distribution Simulations of Impedance Tomography Electrode Combinations , 2005 .

[25]  John G. Webster,et al.  A Fully Automated Multichannel Digital Electrical Impedance Plethysmograph , 2008 .

[26]  Behnam Askarian,et al.  Cuff-Less Blood Pressure Monitoring System Using Smartphones , 2020, IEEE Access.

[27]  Nicholas Bari Olivier,et al.  Estimation of Pulse Transit Time as a Function of Blood Pressure Using a Nonlinear Arterial Tube-Load Model , 2017, IEEE Transactions on Biomedical Engineering.

[28]  SeongHwan Cho,et al.  A bio-impedance measurement system for portable monitoring of heart rate and pulse wave velocity using small body area , 2009, 2009 IEEE International Symposium on Circuits and Systems.

[29]  Dae-Geun Jang,et al.  Pulse Transit Time-Pulse Wave Analysis Fusion Based on Wearable Wrist Ballistocardiogram for Cuff-Less Blood Pressure Trend Tracking , 2020, IEEE Access.

[30]  A. Lowe,et al.  Simulation of impedance measurements at human forearm within 1 kHz to 2 MHz , 2016 .

[31]  Roozbeh Jafari,et al.  Noninvasive Cuffless Blood Pressure Estimation Using Pulse Transit Time and Impedance Plethysmography , 2019, IEEE Transactions on Biomedical Engineering.

[32]  Voicu Groza,et al.  Coefficient-Free Blood Pressure Estimation Based on Pulse Transit Time–Cuff Pressure Dependence , 2013, IEEE Transactions on Biomedical Engineering.

[33]  E. Lakatta,et al.  Recommendations for Improving and Standardizing Vascular Research on Arterial Stiffness: A Scientific Statement From the American Heart Association. , 2015, Hypertension.

[34]  Roozbeh Jafari,et al.  An Accurate Bioimpedance Measurement System for Blood Pressure Monitoring , 2018, Sensors.

[35]  Jackson T. Wright,et al.  Measurement of Blood Pressure in Humans: A Scientific Statement From the American Heart Association. , 2019, Hypertension.

[36]  Shien-Fong Lin,et al.  Wearable Piezoelectric-Based System for Continuous Beat-to-Beat Blood Pressure Measurement , 2020, Sensors.

[37]  Yuan-Ting Zhang,et al.  Continuous Cuffless Blood Pressure Estimation Using Pulse Transit Time and Photoplethysmogram Intensity Ratio , 2016, IEEE Transactions on Biomedical Engineering.

[38]  J.G. Webster,et al.  AC instrumentation amplifier for bioimpedance measurements , 1993, IEEE Transactions on Biomedical Engineering.