A polymorphism associated with entrepreneurship: evidence from dopamine receptor candidate genes

The tendency to be an entrepreneur may be influenced by genetic variation. Sensation seeking is more common among entrepreneurs than among the general population. Twin studies show that the tendency to be an entrepreneur is heritable and that common genes influence both sensation seeking and entrepreneurial tendency (Nicolaou et al. Manag Sci 54:167–179, 2008a; Strateg Entrep J 2:7–21, 2008b). Since dopamine receptor genes have been associated with novelty seeking/sensation seeking (Benjamin et al. Nat Genet 12:81–84, 1996; Ebstein et al. Nat Genet 12:78–80, 1996; Noblett and Coccaro Curr Psychiatry Rep 7:73–80, 2005), and attention deficit hyperactivity disorder (ADHD) has been reported to occur at greater rates among entrepreneurs, we examined the association between five dopamine receptor genes and four ADHD-associated genes, with the tendency to be an entrepreneur in a sample of 1,335 individuals from the UK. We found a single nucleotide polymorphism (rs1486011) of the DRD3 gene on chromosome 3 to be significantly associated with the tendency to be an entrepreneur. This result is the first evidence of the association of a specific gene with entrepreneurship. Further studies are needed to replicate this association.

[1]  H J Eysenck,et al.  Sensation seeking in England and America: cross-cultural, age, and sex comparisons. , 1978, Journal of consulting and clinical psychology.

[2]  M. Zuckerman.  Sensation Seeking : Beyond the Optimal Level of Arousal , 1979 .

[3]  Jean-Jacques Laffont,et al.  A General Equilibrium Entrepreneurial Theory of Firm Formation Based on Risk Aversion , 1979, Journal of Political Economy.

[4]  Philip Seeman,et al.  Cloning of the gene for a human dopamine D4 receptor with high affinity for the antipsychotic clozapine , 1991, Nature.

[5]  R. Klein,et al.  Adult outcome of hyperactive boys. Educational achievement, occupational rank, and psychiatric status. , 1993, Archives of general psychiatry.

[6]  M. Zuckerman.  Behavioral Expressions and Biosocial Bases of Sensation Seeking , 1994 .

[7]  Philippe Froguel,et al.  Chromosomal mapping of genetic loci associated with non-insulin dependent diabetes in the GK rat , 1996, Nature Genetics.

[8]  R. Ebstein,et al.  Dopamine D4 receptor (D4DR) exon III polymorphism associated with the human personality trait of Novelty Seeking , 1996, Nature Genetics.

[9]  D. Murphy,et al.  Population and familial association between the D4 dopamine receptor gene and measures of Novelty Seeking , 1996, Nature Genetics.

[10]  K. Neve,et al.  Dopamine Receptors , 2008 .

[11]  D. Souery,et al.  Association between novelty-seeking and the dopamine D3 receptor gene in bipolar patients: a preliminary report. , 1998, American journal of medical genetics.

[12]  Per Davidsson,et al.  Where do they come from? Prevalence and characteristics of nascent entrepreneurs , 2000 .

[13]  T. Arinami,et al.  Identification of a polymorphism in the promoter region of DRD4associated with the human novelty seeking personality trait , 2000, Molecular Psychiatry.

[14]  T. Spector,et al.  Are Twins and Singletons Comparable? A Study of Disease-related and Lifestyle Characteristics in Adult Women , 2001, Twin Research.

[15]  S. Shane.  A General Theory of Entrepreneurship , 2003 .

[16]  Tova Rosenbloom,et al.  Risk evaluation and risky behavior of high and low sensation seekers , 2003 .

[17]  S. Shane.  A General Theory of Entrepreneurship: The Individual-Opportunity Nexus , 2003 .

[18]  D. Nyholt.  A simple correction for multiple testing for single-nucleotide polymorphisms in linkage disequilibrium with each other. , 2004, American journal of human genetics.

[19]  M. Zuckerman.  The Shaping of Personality: Genes, Environments, and Chance Encounters , 2004, Journal of personality assessment.

[20]  E. Coccaro,et al.  Molecular genetics of personality , 2005, Current psychiatry reports.

[21]  J. Li,et al.  Adjusting multiple testing in multilocus analyses using the eigenvalues of a correlation matrix , 2005, Heredity.

[22]  P. Joyce,et al.  Preliminary evidence for an association between a dopamine D3 receptor gene variant and obsessive‐compulsive personality disorder in patients with major depression , 2006, American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics.

[23]  Tim D Spector,et al.  The UK Adult Twin Registry (TwinsUK) , 2006, Twin Research and Human Genetics.

[24]  T. Thornton,et al.  Case-control association testing with related individuals: a more powerful quasi-likelihood score test. , 2007, American journal of human genetics.

[25]  Manuel A. R. Ferreira,et al.  PLINK: a tool set for whole-genome association and population-based linkage analyses. , 2007, American journal of human genetics.

[26]  Scott Shane,et al.  Is the Tendency to Engage in Entrepreneurship Genetic? , 2008, Manag. Sci..

[27]  B. Franke,et al.  The influence of serotonin- and other genes on impulsive behavioral aggression and cognitive impulsivity in children with attention-deficit/hyperactivity disorder (ADHD): Findings from a family-based association test (FBAT) analysis. , 2008, Behavioral and brain functions : BBF.

[28]  T. Spector,et al.  The influence of sensation seeking in the heritability of entrepreneurship , 2008 .

[29]  B. Jeon,et al.  Association of DRD3 and GRIN2B with impulse control and related behaviors in Parkinson's disease , 2009, Movement disorders : official journal of the Movement Disorder Society.

[30]  S. Faraone,et al.  Molecular genetics of attention deficit hyperactivity disorder. , 2010, The Psychiatric clinics of North America.

[31]  J. Kennedy,et al.  Association of functional variants in the dopamine D2-like receptors with risk for gambling behaviour in healthy Caucasian subjects , 2010, Biological Psychology.