Synthesis and Characterization of Nano-encapsulated Drug Delivery System for Bone Loss

A formulation of nano-encapsulated enantiomer of (+)promethazine with desired release rate has been synthesized for establish a localized drug delivery system. It was tested on a hind limb suspension (HLS) disuse rat model, and by using a non-destructive Nuclear Magnetic Resonance (NMR), and xray techniques to qualitatively evaluate the effectiveness of the new bone formations. Our studies suggest that nanoencapsulated (+)promethazine in controlled release formulations are effective in promoting bone growth in a rat model. Conjugating bone-targeting functional groups to the nanoparticles further enhances the efficacy of the drug. Keywords-nano-encapsulation, bone, NMR

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