Urothelial bladder carcinoma in young patients is characterized by a relatively good prognosis

Abstract Introduction and aim. Urothelial bladder carcinoma (UBC) is a very rare condition in patients aged below 50 years. The aim of the study was to answer the question whether the characteristics of cancer in this group of patients differ from general UBC features. Material and methods. Altogether 2160 patients treated with primary transurethral resection due to a bladder tumor were included in the study. The mean age of the cohort was 69.1 years (range 11–100). Patients were divided into three subgroups depending on age: age <41 years (group 1), age 41–50 years (group 2), age >50 years (group 3). Sex ratio, tumor grade, and stage of disease were recorded. Results. Women constituted 18.5%, 19.2%, and 25.8% of the patients in groups 1, 2, and 3, respectively (P < 0.05). WHO grade 3 tumors were diagnosed in 0%, 8.5%, and 17.2%, respectively (P < 0.05). Non-invasive papillary carcinoma was found in 100.0%, 76.7%, and 62.7%, respectively (P < 0.05). The incidence of muscle-invasive bladder cancer was 0%, 11.0%, and 15.6%, respectively (P < 0.05). Conclusions. Pathological characteristics of UBC are dependent on the patients’ age. Being a very rare condition, UBC in young patients is characterized by a relatively good prognosis.

[1]  F. Montorsi,et al.  Clinical reliability of the 2004 WHO histological classification system compared with the 1973 WHO system for Ta primary bladder tumors. , 2011, The Journal of urology.

[2]  M. Babjuk,et al.  EAU guidelines on non-muscle-invasive urothelial carcinoma of the bladder, the 2011 update. , 2011, European urology.

[3]  D. Berney,et al.  Handling and reporting of transurethral resection specimens of the bladder in Europe: a web‐based survey by the European Network of Uropathology (ENUP) , 2011, Histopathology.

[4]  Y. Lotan,et al.  Disease-free survival at 2 or 3 years correlates with 5-year overall survival of patients undergoing radical cystectomy for muscle invasive bladder cancer. , 2011, The Journal of urology.

[5]  S. Vallasciani,et al.  Transitional cell carcinoma of the bladder in children and adolescents: six-case series and review of the literature. , 2010, Journal of pediatric urology.

[6]  S. Alanee,et al.  Bladder malignancies in children aged <18 years: results from the Surveillance, Epidemiology and End Results database , 2010, BJU international.

[7]  G. Sung,et al.  Differences in tumor characteristics and prognosis in newly diagnosed Ta, T1 urothelial carcinoma of bladder according to patient age. , 2009, Urology.

[8]  Jun Chen,et al.  Relationship between patient age and superficial transitional cell carcinoma characteristics. , 2008, Urology.

[9]  C. Marsit,et al.  Survival following the diagnosis of noninvasive bladder cancer: WHO/International Society of Urological Pathology versus WHO classification systems. , 2007, The Journal of urology.

[10]  P. Humphrey,et al.  Urothelial neoplasms in patients 20 years or younger: a clinicopathological analysis using the world health organization 2004 bladder consensus classification. , 2005, The Journal of urology.

[11]  G. Rossi,et al.  Superficial papillary urothelial carcinomas in young and elderly patients: a comparative study , 2004, BJU international.

[12]  J. Biserte,et al.  [Bladder tumor in young patients: a series of 26 cases. Comparison with a review of the literature]. , 2003, Progres en urologie : journal de l'Association francaise d'urologie et de la Societe francaise d'urologie.

[13]  M. Janssen-Heijnen,et al.  Histological grading of papillary urothelial carcinoma of the bladder: prognostic value of the 1998 WHO/ISUP classification system and comparison with conventional grading systems , 2002, Journal of clinical pathology.

[14]  G. Dalbagni,et al.  Transitional cell carcinoma of the bladder in young adults: presentation, natural history and outcome. , 2002, The Journal of urology.

[15]  M. Vahedi,et al.  Superficial Bladder Tumors in Patients under 40 Years of Age: Clinical, Prognostic and Cytogenetic Aspects , 2001, Urologia Internationalis.

[16]  G. Steinberg,et al.  Correlation between biopsy and radical cystectomy in assessing grade and depth of invasion in bladder urothelial carcinoma. , 2001, Urology.

[17]  D. Theodorescu,et al.  Impact of second opinion pathology in the definitive management of patients with bladder carcinoma , 2001, Cancer.

[18]  R Sylvester,et al.  The role and impact of pathology review on stage and grade assessment of stages Ta and T1 bladder tumors: a combined analysis of 5 European Organization for Research and Treatment of Cancer Trials. , 2000, The Journal of urology.

[19]  J. Cheville,et al.  Grading and staging of bladder carcinoma in transurethral resection specimens. Correlation with 105 matched cystectomy specimens. , 2000, American journal of clinical pathology.

[20]  G. Sauter,et al.  Clinical significance of interobserver differences in the staging and grading of superficial bladder cancer , 2000, BJU international.

[21]  L. ParraMuntaner,et al.  Transitional cell bladder carcinoma in patients younger than 40 years of age , 1998 .

[22]  S. Bennani,et al.  [Bladder tumors in young patients]. , 1998, Progres en urologie : journal de l'Association francaise d'urologie et de la Societe francaise d'urologie.

[23]  A. Kural,et al.  Transitional cell carcinoma of the bladder in patients under 40 years of age , 1994, International Urology and Nephrology.

[24]  M. Babjuk,et al.  [EAU guidelines on non-muscle-invasive urothelial carcinoma of the bladder, the 2011 update]. , 2012, Actas urologicas espanolas.

[25]  A. Taşçı,et al.  Staging error in the Bladder tumor: The correlation between stage of tur and cystectomy , 2004, International Urology and Nephrology.

[26]  F. J. Madrid García,et al.  [Transitional cell bladder carcinoma in patients younger than 40 years of age]. , 1998, Archivos españoles de urología.

[27]  J. Tyczynski,et al.  Cancer in Poland. , 1993, Cancer detection and prevention.