Aging: therapeutics for a healthy future

[1]  V. Kheifets,et al.  Plasma-Based Strategies for Therapeutic Modulation of Brain Aging , 2019, Neurotherapeutics.

[2]  M. Gorospe,et al.  Senolytic therapy alleviates Aβ-associated oligodendrocyte progenitor cell senescence and cognitive deficits in an Alzheimer’s disease model , 2019, Nature Neuroscience.

[3]  J. Shay,et al.  Telomeres and telomerase: three decades of progress , 2019, Nature Reviews Genetics.

[4]  Miia Kivipelto,et al.  Lifestyle interventions to prevent cognitive impairment, dementia and Alzheimer disease , 2018, Nature Reviews Neurology.

[5]  P. Robbins,et al.  Fisetin is a senotherapeutic that extends health and lifespan , 2018, EBioMedicine.

[6]  G. Comi,et al.  In Vivo Transient and Partial Cell Reprogramming to Pluripotency as a Therapeutic Tool for Neurodegenerative Diseases , 2018, Molecular Neurobiology.

[7]  Arwen W. Gao,et al.  Forward and reverse genetics approaches to uncover metabolic aging pathways in Caenorhabditis elegans. , 2017, Biochimica et biophysica acta. Molecular basis of disease.

[8]  O. Lushchak,et al.  Implementation of longevity-promoting supplements and medications in public health practice: achievements, challenges and future perspectives , 2017, Journal of Translational Medicine.

[9]  W. Wagner.  Epigenetic aging clocks in mice and men , 2017, Genome Biology.

[10]  Douglas E. Vaughan,et al.  Molecular and physiological manifestations and measurement of aging in humans , 2017, Aging cell.

[11]  M. Blagosklonny.  From rapalogs to anti-aging formula , 2017, Oncotarget.

[12]  Abel Soto-Gamez,et al.  Therapeutic interventions for aging: the case of cellular senescence. , 2017, Drug discovery today.

[13]  R. Morimoto,et al.  Shaping proteostasis at the cellular, tissue, and organismal level , 2017, The Journal of cell biology.

[14]  Izumi V. Hinkson,et al.  Human umbilical cord plasma proteins revitalize hippocampal function in aged mice , 2017, Nature.

[15]  Felix Krueger,et al.  Multi-tissue DNA methylation age predictor in mouse , 2017, bioRxiv.

[16]  T. Finkel,et al.  Key proteins and pathways that regulate lifespan , 2017, The Journal of Biological Chemistry.

[17]  F. Panza,et al.  Emerging biomarkers and screening for cognitive frailty , 2017, Aging Clinical and Experimental Research.

[18]  Christine A. Sedore,et al.  Impact of genetic background and experimental reproducibility on identifying chemical compounds with robust longevity effects , 2017, Nature Communications.

[19]  K. Lau,et al.  Effect of aging on stem cells , 2017, World journal of experimental medicine.

[20]  Tony Wyss-Coray,et al.  Ageing, neurodegeneration and brain rejuvenation , 2016, Nature.

[21]  M. Levine,et al.  DNA methylation-based measures of biological age: meta-analysis predicting time to death , 2016, Aging.

[22]  K. Kaestner,et al.  Effects of ageing and senescence on pancreatic β‐cell function , 2016, Diabetes, obesity & metabolism.

[23]  Shahrukh K Hashmi,et al.  Strategies and Challenges in Clinical Trials Targeting Human Aging , 2016, The journals of gerontology. Series A, Biological sciences and medical sciences.

[24]  S. Kritchevsky,et al.  Metformin as a Tool to Target Aging. , 2016, Cell metabolism.

[25]  Ali Torkamani,et al.  Whole-Genome Sequencing of a Healthy Aging Cohort , 2016, Cell.

[26]  Vadim N. Gladyshev,et al.  Aging: progressive decline in fitness due to the rising deleteriome adjusted by genetic, environmental, and stochastic processes , 2016, Aging cell.

[27]  I. Laher,et al.  Exercise Modulates Oxidative Stress and Inflammation in Aging and Cardiovascular Diseases , 2015, Oxidative medicine and cellular longevity.

[28]  N. Sharpless,et al.  Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice , 2015, Nature Medicine.

[29]  A. Cuervo,et al.  Proteostasis and aging , 2015, Nature Network Boston.

[30]  D. Baker,et al.  Cellular senescence in aging and age-related disease: from mechanisms to therapy , 2015, Nature Medicine.

[31]  M. Kaeberlein,et al.  Biochemical Genetic Pathways that Modulate Aging in Multiple Species. , 2015, Cold Spring Harbor perspectives in medicine.

[32]  B. Kennedy,et al.  Muscle-specific 4E-BP1 signaling activation improves metabolic parameters during aging and obesity. , 2015, Journal of Clinical Investigation.

[33]  A. Kalinkovich,et al.  Sarcopenia – The search for emerging biomarkers , 2015, Ageing Research Reviews.

[34]  Gregor Bieri,et al.  β2-microglobulin is a systemic pro-aging factor that impairs cognitive function and neurogenesis , 2015, Nature Medicine.

[35]  R. Touyz,et al.  Vascular biology of ageing—Implications in hypertension , 2015, Journal of Molecular and Cellular Cardiology.

[36]  E. Schadt,et al.  Geroscience: Linking Aging to Chronic Disease , 2014, Cell.

[37]  J. Halcox,et al.  Can people with type 2 diabetes live longer than those without? A comparison of mortality in people initiated with metformin or sulphonylurea monotherapy and matched, non‐diabetic controls , 2014, Diabetes, obesity & metabolism.

[38]  E. Masliah,et al.  Let-7 coordinately suppresses components of the amino acid sensing pathway to repress mTORC1 and induce autophagy. , 2014, Cell metabolism.

[39]  J. Elmquist,et al.  Xbp1s in Pomc neurons connects ER stress with energy balance and glucose homeostasis. , 2014, Cell metabolism.

[40]  Shaday Michán.  Calorie restriction and NAD⁺/sirtuin counteract the hallmarks of aging. , 2014, Frontiers in Bioscience.

[41]  Richard T. Lee,et al.  Vascular and Neurogenic Rejuvenation of the Aging Mouse Brain by Young Systemic Factors , 2014, Science.

[42]  S. Horvath.  DNA methylation age of human tissues and cell types , 2013, Genome Biology.

[43]  S. Anton,et al.  Fasting or caloric restriction for Healthy Aging , 2013, Experimental Gerontology.

[44]  E. Mercken,et al.  Metformin improves healthspan and lifespan in mice , 2013, Nature Communications.

[45]  Manuel Serrano,et al.  The Hallmarks of Aging , 2013, Cell.

[46]  Lan Ye,et al.  Rapalogs and mTOR inhibitors as anti-aging therapeutics. , 2013, The Journal of clinical investigation.

[47]  Linda Partridge,et al.  Ageing as a Risk Factor for Disease , 2012, Current Biology.

[48]  A. Podtelezhnikov,et al.  Molecular Insights into the Pathogenesis of Alzheimer's Disease and Its Relationship to Normal Aging , 2011, PloS one.

[49]  N. LeBrasseur,et al.  Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders , 2011, Nature.

[50]  J. Kaye,et al.  The aging systemic milieu negatively regulates neurogenesis and cognitive function , 2011, Nature.

[51]  R. A. Miller,et al.  Design of aging intervention studies: the NIA interventions testing program , 2008, AGE.

[52]  Arthur F Kramer,et al.  Exercise, cognition, and the aging brain. , 2006, Journal of applied physiology.

[53]  Candace F. McDaniel.  Diabetes: A model of oxidative accelerated aging , 1999, AGE.

[54]  Tadashi Kaname,et al.  Mutation of the mouse klotho gene leads to a syndrome resembling ageing , 1997, Nature.

[55]  L. Tian,et al.  Safety, Tolerability, and Feasibility of Young Plasma Infusion in the Plasma for Alzheimer Symptom Amelioration Study: A Randomized Clinical Trial , 2019, JAMA neurology.

[56]  P. Robbins,et al.  Treating Age-Related Diseases with Somatic Stem Cells. , 2018, Advances in Experimental Medicine and Biology.

[57]  R. Vandenbroucke,et al.  ouse models of ageing and their relevance to disease , 2016 .