Recent advances in the role of neutrophils and neutrophil extracellular traps in acute pancreatitis.

[1]  F. Underwood,et al.  Global Incidence of Acute Pancreatitis is Increasing Over Time: A Systematic Review and Meta-Analysis. , 2021, Gastroenterology.

[2]  Wei Zhao,et al.  Protectin D1 decreases pancreatitis severity in mice by inhibiting neutrophil extracellular trap formation. , 2021, International immunopharmacology.

[3]  N. Lu,et al.  The Role of Neutrophils and Neutrophil Extracellular Traps in Acute Pancreatitis , 2021, Frontiers in Cell and Developmental Biology.

[4]  Jing Hu,et al.  Targeting neutrophil extracellular traps in severe acute pancreatitis treatment , 2020, Therapeutic advances in gastroenterology.

[5]  L. Gershwin,et al.  A Review of Neutrophil Extracellular Traps (NETs) in Disease: Potential Anti-NETs Therapeutics , 2020, Clinical Reviews in Allergy & Immunology.

[6]  Ping Wang,et al.  Extracellular cold-inducible RNA-binding protein regulates neutrophil extracellular trap formation and tissue damage in acute pancreatitis , 2020, Laboratory Investigation.

[7]  D. Wagner,et al.  Cellular Mechanisms of NETosis. , 2020, Annual review of cell and developmental biology.

[8]  T. Iba,et al.  The influence of hyperglycemia on neutrophil extracellular trap formation and endothelial glycocalyx damage in a mouse model of type 2 diabetes. , 2020, Microcirculation.

[9]  C. Weber,et al.  Programmed ‘disarming’ of the neutrophil proteome reduces the magnitude of inflammation , 2020, Nature Immunology.

[10]  M. Kaplan,et al.  NETs spread ever wider in rheumatic diseases , 2019, Nature Reviews Rheumatology.

[11]  G. Lupattelli,et al.  Increased plasmatic NETs by-products in patients in severe obesity , 2019, Scientific Reports.

[12]  P. Cohen,et al.  Genetic variations in A20 DUB domain provide a genetic link to citrullination and neutrophil extracellular traps in systemic lupus erythematosus , 2019, Annals of the rheumatic diseases.

[13]  L. Koenderman,et al.  The Neutrophil Life Cycle. , 2019, Trends in immunology.

[14]  O. Soehnlein,et al.  Biological Roles of Neutrophil-Derived Granule Proteins and Cytokines. , 2019, Trends in immunology.

[15]  P. Kubes,et al.  Neutrophils and NETs in modulating acute and chronic inflammation. , 2019, Blood.

[16]  F. Scolari,et al.  Neutrophil Extracellular Traps Profiles in Patients with Incident Systemic Lupus Erythematosus and Lupus Nephritis , 2019, The Journal of Rheumatology.

[17]  J. Mayerle,et al.  Genetics, Cell Biology, and Pathophysiology of Pancreatitis. , 2019, Gastroenterology.

[18]  M. Lotze,et al.  Enhanced Neutrophil Extracellular Trap Formation in Acute Pancreatitis Contributes to Disease Severity and Is Reduced by Chloroquine , 2019, Front. Immunol..

[19]  Jennifer L Lund,et al.  Burden and Cost of Gastrointestinal, Liver, and Pancreatic Diseases in the United States: Update 2018. , 2019, Gastroenterology.

[20]  K. Ley,et al.  Neutrophils: New insights and open questions , 2018, Science Immunology.

[21]  M. Mörgelin,et al.  Targeting peptidylarginine deiminase reduces neutrophil extracellular trap formation and tissue injury in severe acute pancreatitis , 2018, Journal of cellular physiology.

[22]  Weiqian Chen,et al.  Neutrophil Function in an Inflammatory Milieu of Rheumatoid Arthritis , 2018, Journal of immunology research.

[23]  D. Yadav,et al.  Global epidemiology and holistic prevention of pancreatitis , 2018, Nature Reviews Gastroenterology & Hepatology.

[24]  I. Adcock,et al.  Update on Neutrophil Function in Severe Inflammation , 2018, Front. Immunol..

[25]  O. Tatsiy,et al.  Physiological Stimuli Induce PAD4-Dependent, ROS-Independent NETosis, With Early and Late Events Controlled by Discrete Signaling Pathways , 2018, Front. Immunol..

[26]  M. Bortolozzi,et al.  The antidiabetic drug metformin blunts NETosis in vitro and reduces circulating NETosis biomarkers in vivo , 2018, Acta Diabetologica.

[27]  C. Rosales Neutrophil: A Cell with Many Roles in Inflammation or Several Cell Types? , 2018, Front. Physiol..

[28]  Jaewoo Lee,et al.  Immunothrombotic Activity of Damage-Associated Molecular Patterns and Extracellular Vesicles in Secondary Organ Failure Induced by Trauma and Sterile Insults , 2018, Front. Immunol..

[29]  Jing Wang Neutrophils in tissue injury and repair , 2018, Cell and Tissue Research.

[30]  A. Manda-Handzlik,et al.  Azithromycin and Chloramphenicol Diminish Neutrophil Extracellular Traps (NETs) Release , 2017, International journal of molecular sciences.

[31]  P. Boor,et al.  Particles of different sizes and shapes induce neutrophil necroptosis followed by the release of neutrophil extracellular trap-like chromatin , 2017, Scientific Reports.

[32]  Wei Huang,et al.  Systemic histone release disrupts plasmalemma and contributes to necrosis in acute pancreatitis. , 2017, Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.].

[33]  P. Kubes,et al.  Visualizing the function and fate of neutrophils in sterile injury and repair , 2017, Science.

[34]  N. Maugeri,et al.  Low molecular weight heparins prevent the induction of autophagy of activated neutrophils and the formation of neutrophil extracellular traps , 2017, Pharmacological research.

[35]  M. Schön,et al.  Neutrophil extracellular traps: protagonists of cancer progression? , 2017, Oncogene.

[36]  W. Robinson,et al.  Synovial fibroblast-neutrophil interactions promote pathogenic adaptive immunity in rheumatoid arthritis , 2017, Science Immunology.

[37]  P. Kubes,et al.  An emerging role for neutrophil extracellular traps in noninfectious disease , 2017, Nature Medicine.

[38]  J. Tenhunen,et al.  HMGB1 and Histones Play a Significant Role in Inducing Systemic Inflammation and Multiple Organ Dysfunctions in Severe Acute Pancreatitis , 2017, International journal of inflammation.

[39]  Hideki Hayashi,et al.  Peptidylarginine deiminase 4 promotes age-related organ fibrosis , 2017, The Journal of experimental medicine.

[40]  A. Bengtsson,et al.  Blood-borne phagocytes internalize urate microaggregates and prevent intravascular NETosis by urate crystals , 2016, Scientific Reports.

[41]  M. Cecchini,et al.  Ultrastructural Characterization of the Lower Motor System in a Mouse Model of Krabbe Disease , 2016, Scientific Reports.

[42]  Vanessa A Mackley,et al.  Cytoskeletal abnormalities and neutrophil dysfunction in WDR1 deficiency. , 2016, Blood.

[43]  V. Chow,et al.  Effect of High-Fat Diet on the Formation of Pulmonary Neutrophil Extracellular Traps during Influenza Pneumonia in BALB/c Mice , 2016, Front. Immunol..

[44]  J. Pagano,et al.  Viral Carcinogenesis Beyond Malignant Transformation: EBV in the Progression of Human Cancers. , 2016, Trends in microbiology.

[45]  S. Nishio,et al.  Peptidylarginine Deiminase Inhibitor Suppresses Neutrophil Extracellular Trap Formation and MPO-ANCA Production , 2016, Front. Immunol..

[46]  T. Rabelink,et al.  A novel method for high-throughput detection and quantification of neutrophil extracellular traps reveals ROS-independent NET release with immune complexes. , 2016, Autoimmunity reviews.

[47]  S. Nourshargh,et al.  Reverse Migration of Neutrophils: Where, When, How, and Why? , 2016, Trends in immunology.

[48]  V. Pascual,et al.  Oxidized mitochondrial nucleoids released by neutrophils drive type I interferon production in human lupus , 2016, The Journal of experimental medicine.

[49]  M. Neurath,et al.  Externalized decondensed neutrophil chromatin occludes pancreatic ducts and drives pancreatitis , 2016, Nature Communications.

[50]  G. Engelhardt,et al.  Ethylmercury and Hg2+ induce the formation of neutrophil extracellular traps (NETs) by human neutrophil granulocytes , 2016, Archives of Toxicology.

[51]  I. Nagaoka,et al.  Heparins attenuated histone-mediated cytotoxicity in vitro and improved the survival in a rat model of histone-induced organ dysfunction , 2015, Intensive Care Medicine Experimental.

[52]  E. Zhang,et al.  Neutrophil Extracellular Traps Induce Trypsin Activation, Inflammation, and Tissue Damage in Mice With Severe Acute Pancreatitis. , 2015, Gastroenterology.

[53]  A. Bengtsson,et al.  PHAGOCYTES , GRANULOCYTES , AND MYELOPOIESIS A novel mechanism for NETosis provides antimicrobial defense at the oral mucosa , 2015 .

[54]  Ping Xu,et al.  Central role of neutrophil in the pathogenesis of severe acute pancreatitis , 2015, Journal of cellular and molecular medicine.

[55]  R. Zubarev,et al.  Release of Active Peptidyl Arginine Deiminases by Neutrophils Can Explain Production of Extracellular Citrullinated Autoantigens in Rheumatoid Arthritis Synovial Fluid , 2015, Arthritis & rheumatology.

[56]  C. Kahn,et al.  Diabetes primes neutrophils to undergo NETosis, which impairs wound healing , 2015, Nature Medicine.

[57]  Paul R Thompson,et al.  Protein Arginine Deiminases and Associated Citrullination: Physiological Functions and Diseases Associated with Dysregulation. , 2015, Current drug targets.

[58]  J. Griffin,et al.  Activated protein C: biased for translation. , 2015, Blood.

[59]  Shi-qi Lu,et al.  Depletion of Neutrophils Protects Against L-Arginine-Induced Acute Pancreatitis in Mice , 2015, Cellular Physiology and Biochemistry.

[60]  R. Gray,et al.  NETs and CF Lung Disease: Current Status and Future Prospects , 2015, Antibiotics.

[61]  M. Lotze,et al.  The Receptor for Advanced Glycation End Products (RAGE) Enhances Autophagy and Neutrophil Extracellular Traps in Pancreatic Cancer , 2015, Cancer Gene Therapy.

[62]  H. Thorlacius,et al.  Inhibition of Ras signalling reduces neutrophil infiltration and tissue damage in severe acute pancreatitis. , 2015, European journal of pharmacology.

[63]  Haichao Wang,et al.  HMGB1 in health and disease. , 2014, Molecular aspects of medicine.

[64]  F. Mach,et al.  Treatment with Evasin‐3 abrogates neutrophil‐mediated inflammation in mouse acute pancreatitis , 2014, European journal of clinical investigation.

[65]  M. Bauer,et al.  Impact of plasma histones in human sepsis and their contribution to cellular injury and inflammation , 2014, Critical Care.

[66]  J. Hodgin,et al.  Peptidylarginine deiminase inhibition disrupts NET formation and protects against kidney, skin and vascular disease in lupus-prone MRL/lpr mice , 2014, Annals of the rheumatic diseases.

[67]  M. Cassatella,et al.  Social networking of human neutrophils within the immune system. , 2014, Blood.

[68]  A. Zychlinsky,et al.  A Myeloperoxidase-Containing Complex Regulates Neutrophil Elastase Release and Actin Dynamics during NETosis , 2014, Cell reports.

[69]  V. Kadirkamanathan,et al.  A Zebrafish Compound Screen Reveals Modulation of Neutrophil Reverse Migration as an Anti-Inflammatory Mechanism , 2014, Science Translational Medicine.

[70]  C. Carmona-Rivera,et al.  Neutrophil extracellular traps induce endothelial dysfunction in systemic lupus erythematosus through the activation of matrix metalloproteinase-2 , 2014, Annals of the rheumatic diseases.

[71]  H. Hemker,et al.  Nonanticoagulant heparin prevents histone-mediated cytotoxicity in vitro and improves survival in sepsis. , 2014, Blood.

[72]  Remco Loos,et al.  Citrullination regulates pluripotency and histone H1 binding to chromatin , 2014, Nature.

[73]  T. Mayadas,et al.  The multifaceted functions of neutrophils. , 2014, Annual review of pathology.

[74]  Tomohiro Watanabe,et al.  Serum neutrophil extracellular trap levels predict thrombotic microangiopathy after allogeneic stem cell transplantation. , 2013, Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation.

[75]  B. Gao,et al.  Chronic plus binge ethanol feeding synergistically induces neutrophil infiltration and liver injury in mice: A critical role for E‐selectin , 2013, Hepatology.

[76]  K. Tracey,et al.  Cold-inducible RNA-binding protein (CIRP) triggers inflammatory responses in hemorrhagic shock and sepsis , 2013, Nature Medicine.

[77]  S. Renshaw,et al.  Zebrafish as a model for the study of neutrophil biology , 2013, Journal of leukocyte biology.

[78]  Kristina Buac,et al.  Pseudogout-Associated Inflammatory Calcium Pyrophosphate Dihydrate Microcrystals Induce Formation of Neutrophil Extracellular Traps , 2013, The Journal of Immunology.

[79]  M. Lindsey,et al.  Neutrophil roles in left ventricular remodeling following myocardial infarction , 2013, Fibrogenesis & tissue repair.

[80]  S. Negrotto,et al.  Regulation of Neutrophil Extracellular Trap Formation by Anti-Inflammatory Drugs , 2013, The Journal of Pharmacology and Experimental Therapeutics.

[81]  J. Dürig,et al.  Revision of the human hematopoietic tree: granulocyte subtypes derive from distinct hematopoietic lineages. , 2013, Cell reports.

[82]  John A. Williams The nobel pancreas: a historical perspective. , 2013, Gastroenterology.

[83]  S. Rankin,et al.  Regulation of Circulating Neutrophil Numbers under Homeostasis and in Disease , 2013, Journal of Innate Immunity.

[84]  Pojen P. Chen,et al.  NETs Are a Source of Citrullinated Autoantigens and Stimulate Inflammatory Responses in Rheumatoid Arthritis , 2013, Science Translational Medicine.

[85]  S. Siitonen,et al.  Patients with acute pancreatitis complicated by organ dysfunction show abnormal peripheral blood polymorphonuclear leukocyte signaling. , 2013, Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.].

[86]  P. Kubes,et al.  Neutrophil recruitment and function in health and inflammation , 2013, Nature Reviews Immunology.

[87]  M. Radic,et al.  Opposition between PKC isoforms regulates histone deimination and neutrophil extracellular chromatin release , 2013, Front. Immun..

[88]  G. Schett,et al.  Bonding the foe – NETting neutrophils immobilize the pro-inflammatory monosodium urate crystals , 2012, Front. Immun..

[89]  P. Zhao,et al.  A SerpinB1 Regulatory Mechanism Is Essential for Restricting Neutrophil Extracellular Trap Generation , 2012, The Journal of Immunology.

[90]  M. Dragunow,et al.  Requirements for NADPH oxidase and myeloperoxidase in neutrophil extracellular trap formation differ depending on the stimulus , 2012, Journal of leukocyte biology.

[91]  R. Andersson,et al.  Acute lung injury in acute pancreatitis--awaiting the big leap. , 2012, Respiratory medicine.

[92]  J. Potempa,et al.  Secretory Leukocyte Proteinase Inhibitor-Competent DNA Deposits Are Potent Stimulators of Plasmacytoid Dendritic Cells: Implication for Psoriasis , 2012, The Journal of Immunology.

[93]  S. Regnér,et al.  Neutrophil‐derived matrix metalloproteinase‐9 is a potent activator of trypsinogen in acinar cells in acute pancreatitis , 2012, Journal of leukocyte biology.

[94]  C. Parkos,et al.  The role of neutrophils during intestinal inflammation , 2012, Mucosal Immunology.

[95]  J. Mayerle,et al.  Tumour necrosis factor α secretion induces protease activation and acinar cell necrosis in acute experimental pancreatitis in mice , 2012, Gut.

[96]  A. Zychlinsky,et al.  Neutrophil function: from mechanisms to disease. , 2012, Annual review of immunology.

[97]  K. Preissner,et al.  Neutrophil Extracellular Traps Directly Induce Epithelial and Endothelial Cell Death: A Predominant Role of Histones , 2012, PloS one.

[98]  B. Lindkvist,et al.  P‐selectin mediates neutrophil rolling and recruitment in acute pancreatitis , 2012, The British journal of surgery.

[99]  W. Meng,et al.  Deoxyribonuclease Is a Potential Counter Regulator of Aberrant Neutrophil Extracellular Traps Formation after Major Trauma , 2012, Mediators of inflammation.

[100]  D. Boumpas,et al.  Neutrophil Extracellular Trap Formation Is Associated with IL-1β and Autophagy-Related Signaling in Gout , 2011, PloS one.

[101]  A. Zychlinsky,et al.  Neutrophil Elastase Enhances Sputum Solubilization in Cystic Fibrosis Patients Receiving DNase Therapy , 2011, PloS one.

[102]  S. Regnér,et al.  Role of neutrophils in the activation of trypsinogen in severe acute pancreatitis , 2011, Journal of leukocyte biology.

[103]  Alberto Mantovani,et al.  Neutrophils in the activation and regulation of innate and adaptive immunity , 2011, Nature Reviews Immunology.

[104]  D. Meyerholz,et al.  Systemic Inflammation with Multiorgan Dysfunction Is the Cause of Death in Murine Ligation-Induced Acute Pancreatitis , 2011, Journal of Gastrointestinal Surgery.

[105]  P. Meda,et al.  Junctional adhesion molecule-C (JAM-C) regulates polarized neutrophil transendothelial cell migration in vivo , 2011, Nature Immunology.

[106]  E. Hirsch,et al.  Regulating neutrophil apoptosis: new players enter the game. , 2011, Trends in immunology.

[107]  P. Vandenabeele,et al.  Neutrophil extracellular trap cell death requires both autophagy and superoxide generation , 2011, Cell Research.

[108]  M. Surette,et al.  A Novel Mechanism of Rapid Nuclear Neutrophil Extracellular Trap Formation in Response to Staphylococcus aureus , 2010, The Journal of Immunology.

[109]  N. Borregaard,et al.  Neutrophils, from marrow to microbes. , 2010, Immunity.

[110]  Abdul Hakkim,et al.  Neutrophil elastase and myeloperoxidase regulate the formation of neutrophil extracellular traps , 2010, The Journal of cell biology.

[111]  J. Hartwig,et al.  Extracellular DNA traps promote thrombosis , 2010, Proceedings of the National Academy of Sciences.

[112]  M. Matthay,et al.  Acute lung injury: epidemiology, pathogenesis, and treatment. , 2010, Journal of aerosol medicine and pulmonary drug delivery.

[113]  R. Talukdar,et al.  Recent developments in acute pancreatitis. , 2009, Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association.

[114]  M. Gilliet,et al.  Self-RNA–antimicrobial peptide complexes activate human dendritic cells through TLR7 and TLR8 , 2009, The Journal of experimental medicine.

[115]  E. Kurt-Jones,et al.  Impact of toll-like receptor 4 on the severity of acute pancreatitis and pancreatitis-associated lung injury in mice , 2009, Gut.

[116]  C. Allis,et al.  Histone hypercitrullination mediates chromatin decondensation and neutrophil extracellular trap formation , 2009, The Journal of cell biology.

[117]  M. Sans,et al.  Regulation of transforming growth factor beta-induced responses by protein kinase A in pancreatic acinar cells. , 2008, American journal of physiology. Gastrointestinal and liver physiology.

[118]  C. Camargo,et al.  Increasing United States hospital admissions for acute pancreatitis, 1988-2003. , 2007, Annals of epidemiology.

[119]  J. Christman,et al.  Airway Epithelium Controls Lung Inflammation and Injury through the NF-κB Pathway1 , 2007, The Journal of Immunology.

[120]  J. Griffin,et al.  The cytoprotective protein C pathway. , 2007 .

[121]  Stephen R. Clark,et al.  Platelet TLR4 activates neutrophil extracellular traps to ensnare bacteria in septic blood , 2007, Nature Medicine.

[122]  F. Mollinedo,et al.  Combinatorial SNARE Complexes Modulate the Secretion of Cytoplasmic Granules in Human Neutrophils1 , 2006, The Journal of Immunology.

[123]  M. Salmon,et al.  Identification of a phenotypically and functionally distinct population of long‐lived neutrophils in a model of reverse endothelial migration , 2006, Journal of leukocyte biology.

[124]  M. Yamada,et al.  Deimination of histone H2A and H4 at arginine 3 in HL-60 granulocytes. , 2005, Biochemistry.

[125]  G. Rutter,et al.  Metformin prevents glucose-induced protein kinase C-beta2 activation in human umbilical vein endothelial cells through an antioxidant mechanism. , 2005, Diabetes.

[126]  K. Tracey,et al.  The "cytokine profile": a code for sepsis. , 2005, Trends in molecular medicine.

[127]  A. Zychlinsky,et al.  Neutrophil Extracellular Traps Kill Bacteria , 2004, Science.

[128]  J. Platt,et al.  Cutting Edge: An Endogenous Pathway to Systemic Inflammatory Response Syndrome (SIRS)-Like Reactions through Toll-Like Receptor 41 , 2004, The Journal of Immunology.

[129]  Jonathan Cohen The immunopathogenesis of sepsis , 2002, Nature.

[130]  H. Redmond,et al.  Lung injury in acute pancreatitis: mechanisms, prevention, and therapy , 2002, Current opinion in critical care.

[131]  S. Holland,et al.  Neutrophils and NADPH oxidase mediate intrapancreatic trypsin activation in murine experimental acute pancreatitis. , 2002, Gastroenterology.

[132]  S. Evans,et al.  Dynamic nature of early organ dysfunction determines outcome in acute pancreatitis , 2002, The British journal of surgery.

[133]  B. Han,et al.  NF-κB activation in pancreas induces pancreatic and systemic inflammatory response , 2002 .

[134]  J Savill,et al.  Apoptosis in post-streptococcal glomerulonephritis , 2001 .

[135]  G. Downey,et al.  Neutrophil activation and acute lung injury , 2001, Current opinion in critical care.

[136]  I. Weissman,et al.  A clonogenic common myeloid progenitor that gives rise to all myeloid lineages , 2000, Nature.

[137]  B. Rau,et al.  Bacterial infection and extent of necrosis are determinants of organ failure in patients with acute necrotizing pancreatitis , 1999, The British journal of surgery.

[138]  M. Fischer,et al.  Antioxidant status in patients with acute respiratory distress syndrome , 1999, Intensive Care Medicine.

[139]  M. Davies,et al.  Systemic inflammatory response syndrome , 1997, The British journal of surgery.

[140]  J. Savill Apoptosis in resolution of inflammation , 1997, Journal of leukocyte biology.

[141]  A. Beaudet,et al.  The role of P-selectin and ICAM-1 in acute lung injury as determined using blocking antibodies and mutant mice. , 1996, Journal of immunology.

[142]  M. Lovell,et al.  Stability of nuclear segments in human neutrophils and evidence against a role for microfilaments or microtubules in their genesis during differentiation of HL60 myelocytes , 1995, Journal of leukocyte biology.

[143]  A. Sauaia,et al.  Early neutrophil sequestration after injury: a pathogenic mechanism for multiple organ failure. , 1995, The Journal of trauma.

[144]  A. Nussler,et al.  Inflammation, immunoregulation, and inducible nitric oxide synthase , 1993, Journal of leukocyte biology.

[145]  S. Shak,et al.  Recombinant human DNase I reduces the viscosity of cystic fibrosis sputum. , 1990, Proceedings of the National Academy of Sciences of the United States of America.

[146]  D. Wagner,et al.  PHAGOCYTES , GRANULOCYTES , AND MYELOPOIESIS P-selectin promotes neutrophil extracellular trap formation in mice , 2015 .

[147]  Tomoaki Inoue,et al.  Metformin and liraglutide ameliorate high glucose-induced oxidative stress via inhibition of PKC-NAD(P)H oxidase pathway in human aortic endothelial cells. , 2014, Atherosclerosis.

[148]  D. Dixon,et al.  Lung injury in acute pancreatitis: mechanisms underlying augmented secondary injury. , 2012, Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.].

[149]  W. Kuebler,et al.  Role of L-selectin in leukocyte sequestration in lung capillaries in a rabbit model of endotoxemia. , 2000, American journal of respiratory and critical care medicine.