The role of mammalian antimicrobial peptides and proteins in awakening of innate host defenses and adaptive immunity

[1]  H. Jörnvall,et al.  The human antimicrobial and chemotactic peptides LL-37 and alpha-defensins are expressed by specific lymphocyte and monocyte populations. , 2000, Blood.

[2]  D. Dimitrov,et al.  Down-regulation of the chemokine receptor CCR5 by activation of chemotactic formyl peptide receptor in human monocytes. , 2000, Blood.

[3]  Ji Ming Wang,et al.  Ll-37, the Neutrophil Granule–And Epithelial Cell–Derived Cathelicidin, Utilizes Formyl Peptide Receptor–Like 1 (Fprl1) as a Receptor to Chemoattract Human Peripheral Blood Neutrophils, Monocytes, and T Cells , 2000, The Journal of experimental medicine.

[4]  S. Stoll,et al.  Differential Regulation of Responsiveness to fMLP and C5a Upon Dendritic Cell Maturation: Correlation with Receptor Expression1 2 , 2000, The Journal of Immunology.

[5]  A. Fauci,et al.  Cathepsin G, a Neutrophil-Derived Serine Protease, Increases Susceptibility of Macrophages to Acute Human Immunodeficiency Virus Type 1 Infection , 2000, Journal of Virology.

[6]  O. Chertov,et al.  Human neutrophil defensins selectively chemoattract naive T and immature dendritic cells , 2000, Journal of leukocyte biology.

[7]  P. A. Raj,et al.  Large-scale synthesis and functional elements for the antimicrobial activity of defensins. , 2000, The Biochemical journal.

[8]  Ji Ming Wang,et al.  Defensins act as potent adjuvants that promote cellular and humoral immune responses in mice to a lymphoma idiotype and carrier antigens. , 2000, International immunology.

[9]  P. Cui,et al.  Chymase is a potent chemoattractant for human monocytes and neutrophils , 2000, Journal of leukocyte biology.

[10]  C. Boudier,et al.  DNA Strongly Impairs the Inhibition of Cathepsin G by α1-Antichymotrypsin and α1-Proteinase Inhibitor* , 2000, The Journal of Biological Chemistry.

[11]  J. Roes,et al.  Impaired immunity and enhanced resistance to endotoxin in the absence of neutrophil elastase and cathepsin G. , 2000, Immunity.

[12]  P. McCray,et al.  A novel murine beta -defensin expressed in tongue, esophagus, and trachea. , 2000, The Journal of biological chemistry.

[13]  T. Ley,et al.  Normal neutrophil function in cathepsin G-deficient mice. , 1999, Blood.

[14]  J. Cowland,et al.  The individual regulation of granule protein mRNA levels during neutrophil maturation explains the heterogeneity of neutrophil granules , 1999, Journal of leukocyte biology.

[15]  James M. Wilson,et al.  Augmentation of Innate Host Defense by Expression of a Cathelicidin Antimicrobial Peptide , 1999, Infection and Immunity.

[16]  Ji Ming Wang,et al.  β-Defensins: Linking Innate and Adaptive Immunity Through Dendritic and T Cell CCR6 , 1999 .

[17]  Jun Yuan,et al.  A cyclic antimicrobial peptide produced in primate leukocytes by the ligation of two truncated alpha-defensins. , 1999, Science.

[18]  L. Matrisian,et al.  Regulation of intestinal alpha-defensin activation by the metalloproteinase matrilysin in innate host defense. , 1999, Science.

[19]  J. Oppenheim,et al.  Cutting edge: immature dendritic cells generated from monocytes in the presence of TGF-beta 1 express functional C-C chemokine receptor 6. , 1999, Journal of immunology.

[20]  M. Gilchrist,et al.  Neutrophil defensins induce histamine secretion from mast cells: mechanisms of action. , 1999, Journal of immunology.

[21]  S. Wattler,et al.  Mouse β-Defensin 3 Is an Inducible Antimicrobial Peptide Expressed in the Epithelia of Multiple Organs , 1999, Infection and Immunity.

[22]  P. Bulet,et al.  Antimicrobial peptides in insects; structure and function. , 1999, Developmental and comparative immunology.

[23]  F. Malavasi,et al.  rC5a directs the in vitro migration of human memory and naive tonsillar B lymphocytes: implications for B cell trafficking in secondary lymphoid tissues. , 1999, Journal of immunology.

[24]  F C Kafatos,et al.  Phylogenetic perspectives in innate immunity. , 1999, Science.

[25]  S. Hirakawa,et al.  Detection of Cryptdin in Mouse Skin , 1999, Clinical Diagnostic Laboratory Immunology.

[26]  M. Ståhle-Bäckdahl,et al.  The Human Cationic Antimicrobial Protein (hCAP18), a Peptide Antibiotic, Is Widely Expressed in Human Squamous Epithelia and Colocalizes with Interleukin-6 , 1999, Infection and Immunity.

[27]  N. Davoust,et al.  Human T cells express the C5a receptor and are chemoattracted to C5a. , 1999, Journal of immunology.

[28]  M. Heinzelmann,et al.  Endocytosis of heparin-binding protein (CAP37) is essential for the enhancement of lipopolysaccharide-induced TNF-alpha production in human monocytes. , 1999, Journal of immunology.

[29]  F. Sallusto,et al.  Mobilizing Dendritic Cells for Tolerance, Priming, and Chronic Inflammation , 1999, The Journal of experimental medicine.

[30]  R I Lehrer,et al.  Antimicrobial peptides in mammalian and insect host defence. , 1999, Current opinion in immunology.

[31]  J. Lillard,et al.  Mechanisms for induction of acquired host immunity by neutrophil peptide defensins. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[32]  D. Davidson,et al.  A novel mouse beta defensin, Defb2, which is upregulated in the airways by lipopolysaccharide , 1999, FEBS letters.

[33]  A. Walls,et al.  Human mast cell chymase induces the accumulation of neutrophils, eosinophils and other inflammatory cells in vivo , 1998, British journal of pharmacology.

[34]  M. Daha,et al.  Inhibition of activation of the classical pathway of complement by human neutrophil defensins. , 1998, Blood.

[35]  E. Pauwels,et al.  Antibacterial activity of human neutrophil defensins in experimental infections in mice is accompanied by increased leukocyte accumulation. , 1998, The Journal of clinical investigation.

[36]  T. Ley,et al.  Augmented inflammatory responses and altered wound healing in cathepsin G-deficient mice. , 1998, Archives of surgery.

[37]  V. Bafna,et al.  Human beta-defensin 2 is a salt-sensitive peptide antibiotic expressed in human lung. , 1998, The Journal of clinical investigation.

[38]  Alan J. Waring,et al.  Activities of LL-37, a Cathelin-Associated Antimicrobial Peptide of Human Neutrophils , 1998, Antimicrobial Agents and Chemotherapy.

[39]  M. Nakazato,et al.  Identification of human beta-defensin-2 in respiratory tract and plasma and its increase in bacterial pneumonia. , 1998, Biochemical and biophysical research communications.

[40]  R. Bals,et al.  The peptide antibiotic LL-37/hCAP-18 is expressed in epithelia of the human lung where it has broad antimicrobial activity at the airway surface. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[41]  C. Caux,et al.  Selective Recruitment of Immature and Mature Dendritic Cells by Distinct Chemokines Expressed in Different Anatomic Sites , 1998, The Journal of experimental medicine.

[42]  H. G. Boman,et al.  Gene‐Encoded Peptide Antibiotics and the Concept of Innate Immunity: An Update Review , 1998, Scandinavian journal of immunology.

[43]  M. Heinzelmann,et al.  Heparin-binding protein (CAP37) is internalized in monocytes and increases LPS-induced monocyte activation. , 1998, Journal of immunology.

[44]  T. Kirikae,et al.  Protective Effects of a Human 18-Kilodalton Cationic Antimicrobial Protein (CAP18)-Derived Peptide against Murine Endotoxemia , 1998, Infection and Immunity.

[45]  R. Steinman,et al.  Dendritic cells and the control of immunity , 1998, Nature.

[46]  James M. Wilson,et al.  Mouse β-Defensin 1 Is a Salt-Sensitive Antimicrobial Peptide Present in Epithelia of the Lung and Urogenital Tract , 1998, Infection and Immunity.

[47]  R I Lehrer,et al.  Antimicrobial peptides of vertebrates. , 1998, Current opinion in immunology.

[48]  S. Galli,et al.  Impaired mast cell-dependent natural immunity in complement C3-deficient mice , 1997, Nature.

[49]  Ji Ming Wang,et al.  Identification of Human Neutrophil-derived Cathepsin G and Azurocidin/CAP37 as Chemoattractants for Mononuclear Cells and Neutrophils , 1997, The Journal of experimental medicine.

[50]  C. Kozak,et al.  The mouse genome encodes a single homolog of the antimicrobial peptide human β‐defensin 1 , 1997, FEBS letters.

[51]  H. Heng,et al.  The human β-defensin-1 and α-defensins are encoded by adjacent genes : Two peptide families with differing disulfide topology share a common ancestry , 1997 .

[52]  P. Hiemstra,et al.  Effect of neutrophil serine proteinases and defensins on lung epithelial cells: modulation of cytotoxicity and IL‐8 production , 1997, Journal of leukocyte biology.

[53]  P. Csermely,et al.  Defensins purified from human granulocytes bind C1q and activate the classical complement pathway like the transmembrane glycoprotein gp41 of HIV-1. , 1997, Molecular immunology.

[54]  J. Schröder,et al.  A peptide antibiotic from human skin , 1997, Nature.

[55]  H. Wigzell,et al.  The Expression of the Gene Coding for the Antibacterial Peptide LL-37 Is Induced in Human Keratinocytes during Inflammatory Disorders* , 1997, The Journal of Biological Chemistry.

[56]  T. Ganz,et al.  Localization of human intestinal defensin 5 in Paneth cell granules , 1997, Infection and immunity.

[57]  P. Hiemstra,et al.  Effect of defensins on interleukin-8 synthesis in airway epithelial cells. , 1997, The American journal of physiology.

[58]  C. Ross,et al.  Chemoattractant properties of PR‐39, a neutrophil antibacterial peptide , 1997, Journal of leukocyte biology.

[59]  P. M. Wilson,et al.  Vitamin A deficiency alters rat neutrophil function. , 1997, The Journal of nutrition.

[60]  T. Ganz,et al.  Purification and characterization of defensins from cystic fibrosis sputum , 1997, Inflammation Research.

[61]  James M. Wilson,et al.  Human β-Defensin-1 Is a Salt-Sensitive Antibiotic in Lung That Is Inactivated in Cystic Fibrosis , 1997, Cell.

[62]  F. Sallusto,et al.  Origin, maturation and antigen presenting function of dendritic cells. , 1997, Current opinion in immunology.

[63]  M. Matsushita.  The Lectin Pathway of the Complement System , 1996, Microbiology and immunology.

[64]  P. Holt,et al.  Brief Definitive Report Dendritic Cells Are Recruited into the Airway Epithelium during the Inflammatory Response to a Broad Spectrum of Stimuli , 2022 .

[65]  P. M. Wilson,et al.  Neutrophil cathepsin G is specifically decreased under vitamin A deficiency. , 1996, Biochimica et biophysica acta.

[66]  R. Lehrer,et al.  Widespread expression of beta‐defensin hBD‐1 in human secretory glands and epithelial cells , 1996, FEBS letters.

[67]  K. Imai,et al.  Enhancement of phagocytosis by corticostatin I (CSI) in cultured mouse peritoneal macrophages. , 1996, Immunopharmacology.

[68]  M. Selsted,et al.  Paneth cell defensins: Endogenous peptide components of intestinal host defense , 1996, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[69]  A. Morelli,et al.  Expression and modulation of C5a receptor (CD88) on skin dendritic cells. Chemotactic effect of C5a on skin migratory dendritic cells , 1996, Immunology.

[70]  Wayne L. Smith,et al.  Purification, primary structures, and antibacterial activities of β-defensins, a new family of antimicrobial peptides from bovine neutrophils. , 1996, The Journal of Biological Chemistry.

[71]  D. Eisenberg,et al.  Solution structure of protegrin-1, a broad-spectrum antimicrobial peptide from porcine leukocytes. , 1996, Chemistry & biology.

[72]  J. Odeberg,et al.  The human gene FALL39 and processing of the cathelin precursor to the antibacterial peptide LL-37 in granulocytes. , 1996, European journal of biochemistry.

[73]  G. Diamond,et al.  Inducible expression of an antibiotic peptide gene in lipopolysaccharide-challenged tracheal epithelial cells. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[74]  J. Bluestone,et al.  CD28/B7 system of T cell costimulation. , 1996, Annual review of immunology.

[75]  S. Abraham,et al.  Mast cell modulation of neutrophil influx and bacterial clearance at sites of infection through TNF-α , 1996, Nature.

[76]  B. Echtenacher,et al.  Critical protective role of mast cells in a model of acute septic peritonitis , 1996, Nature.

[77]  C. Roumestand,et al.  Synthesis and solution structure of the antimicrobial peptide protegrin-1. , 1996, European journal of biochemistry.

[78]  T. Scanlin,et al.  Coordinate induction of two antibiotic genes in tracheal epithelial cells exposed to the inflammatory mediators lipopolysaccharide and tumor necrosis factor alpha , 1996, Infection and immunity.

[79]  E. Greenberg,et al.  Cystic Fibrosis Airway Epithelia Fail to Kill Bacteria Because of Abnormal Airway Surface Fluid , 1996, Cell.

[80]  D. Taub,et al.  T lymphocyte recruitment by interleukin-8 (IL-8). IL-8-induced degranulation of neutrophils releases potent chemoattractants for human T lymphocytes both in vitro and in vivo. , 1996, The Journal of clinical investigation.

[81]  J. Ahearn,et al.  Disruption of the Cr2 locus results in a reduction in B-1a cells and in an impaired B cell response to T-dependent antigen. , 1996, Immunity.

[82]  R. Deberardinis,et al.  Human Enteric Defensins , 1996, The Journal of Biological Chemistry.

[83]  D. Taub,et al.  Identification of Defensin-1, Defensin-2, and CAP37/Azurocidin as T-cell Chemoattractant Proteins Released from Interleukin-8-stimulated Neutrophils (*) , 1996, The Journal of Biological Chemistry.

[84]  Christopher C. Goodnow,et al.  C3d of Complement as a Molecular Adjuvant: Bridging Innate and Acquired Immunity , 1996, Science.

[85]  Domenico Romeo,et al.  Cathelicidins: a novel protein family with a common proregion and a variable C‐terminal antimicrobial domain , 1995, FEBS letters.

[86]  A. Pardi,et al.  Solution structure of bovine neutrophil beta-defensin-12: the peptide fold of the beta-defensins is identical to that of the classical defensins. , 1995, Biochemistry.

[87]  P. Allavena,et al.  Migration of dendritic cells in response to formyl peptides, C5a, and a distinct set of chemokines. , 1995, Journal of immunology.

[88]  A. Johnsen,et al.  hCAP‐18, a cathelin/pro‐bactenecin‐like protein of human neutrophil specific granules , 1995, FEBS letters.

[89]  J. Larrick,et al.  Human CAP18: a novel antimicrobial lipopolysaccharide-binding protein , 1995, Infection and immunity.

[90]  B. Schonwetter,et al.  Epithelial antibiotics induced at sites of inflammation , 1995, Science.

[91]  J. Odeberg,et al.  FALL-39, a putative human peptide antibiotic, is cysteine-free and expressed in bone marrow and testis. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[92]  T. Hase-Yamazaki,et al.  Stimulation of human lymphocytes by cathepsin G. , 1995, Cellular immunology.

[93]  D. Fearon,et al.  The CD19/CR2/TAPA-1 complex of B lymphocytes: linking natural to acquired immunity. , 1995, Annual review of immunology.

[94]  T. Ganz,et al.  Identification of defensin binding to C1 complement , 1994, FEBS letters.

[95]  M. Baggiolini,et al.  Interleukin‐8 processing by neutrophil elastase, cathepsin G and proteinase‐3 , 1994, FEBS letters.

[96]  J. Johansson,et al.  Secondary structure and membrane interaction of PR-39, a Pro+Arg-rich antibacterial peptide. , 1994, European journal of biochemistry.

[97]  B. Morgan,et al.  Clinical complementology: recent progress and future trends , 1994, European journal of clinical investigation.

[98]  J. Larrick,et al.  Characterization of a rabbit cationic protein (CAP18) with lipopolysaccharide-inhibitory activity , 1994, Infection and immunity.

[99]  M. Selsted,et al.  Structure and diversity of the murine cryptdin gene family. , 1994, Genomics.

[100]  C. Gerard,et al.  C5A anaphylatoxin and its seven transmembrane-segment receptor. , 1994, Annual review of immunology.

[101]  B. Dewald,et al.  Interleukin-8 and related chemotactic cytokines--CXC and CC chemokines. , 1994, Advances in immunology.

[102]  J. Cavaillon,et al.  A novel granulocyte-derived peptide with lipopolysaccharide-neutralizing activity. , 1994, Journal of immunology.

[103]  P. Murphy.  The molecular biology of leukocyte chemoattractant receptors. , 1994, Annual review of immunology.

[104]  M. Nakazato,et al.  Establishment of radioimmunoassay for human neutrophil peptides and their increases in plasma and neutrophil in infection. , 1993, Biochemical and biophysical research communications.

[105]  T. Ganz,et al.  Plasma defensin concentrations are elevated in patients with septicemia or bacterial meningitis. , 1993, The Journal of laboratory and clinical medicine.

[106]  J Pohl,et al.  Synthetic bactericidal peptide based on CAP37: a 37-kDa human neutrophil granule-associated cationic antimicrobial protein chemotactic for monocytes. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[107]  M. Selsted,et al.  Characterization of the disulfide motif in BNBD-12, an antimicrobial beta-defensin peptide from bovine neutrophils. , 1993, The Journal of biological chemistry.

[108]  S. Tomlinson.  Complement defense mechanisms. , 1993, Current opinion in immunology.

[109]  A. Pardi,et al.  NMR studies of defensin antimicrobial peptides. 2. Three-dimensional structures of rabbit NP-2 and human HNP-1. , 1992, Biochemistry.

[110]  A. Pardi,et al.  NMR studies of defensin antimicrobial peptides. 1. Resonance assignment and secondary structure determination of rabbit NP-2 and human HNP-1. , 1992, Biochemistry.

[111]  R. Carrell,et al.  Serpins: implications of a mobile reactive centre. , 1992, Current opinion in biotechnology.

[112]  Q. Zhu,et al.  Isolation and mode of action of rabbit corticostatic (antiadrenocorticotropin) peptides. , 1992, Endocrinology.

[113]  H. Rubin.  The biology and biochemistry of antichymotrypsin and its potential role as a therapeutic agent. , 1992, Biological chemistry Hoppe-Seyler.

[114]  A. Bateman,et al.  Corticostatic peptides , 1991, The Journal of Steroid Biochemistry and Molecular Biology.

[115]  J. Tew,et al.  Chemotaxis of germinal centers B cells in response to C5a , 1991, European journal of immunology.

[116]  M. E. Guerra,et al.  Cloning of the cDNA for the serine protease homolog CAP37/azurocidin, a microbicidal and chemotactic protein from human granulocytes. , 1991, Journal of immunology.

[117]  C. Nathan,et al.  Complementary DNA sequence of human neutrophil azurocidin, an antibiotic with extensive homology to serine proteases. , 1991, Biochemical and biophysical research communications.

[118]  A. Svendsen,et al.  Covalent structure of two novel neutrophile leucocyte-derived proteins of porcine and human origin. Neutrophile elastase homologues with strong monocyte and fibroblast chemotactic activities. , 1991, European journal of biochemistry.

[119]  K. Matsushima,et al.  Properties of the novel proinflammatory supergene "intercrine" cytokine family. , 1991, Annual review of immunology.

[120]  H. Imura,et al.  Effects of corticostatin-I on rat adrenal cells in vitro. , 1990, The Journal of endocrinology.

[121]  W. Shafer,et al.  CAP37, a human neutrophil-derived chemotactic factor with monocyte specific activity. , 1990, The Journal of clinical investigation.

[122]  T. Yamashita,et al.  Purification, primary structure, and biological activity of guinea pig neutrophil cationic peptides , 1989, Infection and immunity.

[123]  R. W. Scott,et al.  Purification and characterization of human neutrophil peptide 4, a novel member of the defensin family. , 1989, The Journal of biological chemistry.

[124]  C. Nathan,et al.  Antibiotic proteins of human polymorphonuclear leukocytes. , 1989, Proceedings of the National Academy of Sciences of the United States of America.

[125]  J. Metcalf,et al.  Microbicidal/cytotoxic proteins of neutrophils are deficient in two disorders: Chediak-Higashi syndrome and "specific" granule deficiency. , 1988, The Journal of clinical investigation.

[126]  G. Downey,et al.  Monocyte retention and migration in pulmonary inflammation. Requirement for neutrophils. , 1988, Laboratory investigation; a journal of technical methods and pathology.

[127]  J. Travis.  Structure, function, and control of neutrophil proteinases , 1988 .

[128]  S. Mulay,et al.  Isolation and structure of corticostatin peptides from rabbit fetal and adult lung. , 1988, Proceedings of the National Academy of Sciences of the United States of America.

[129]  T. Ganz.  Extracellular release of antimicrobial defensins by human polymorphonuclear leukocytes , 1987, Infection and immunity.

[130]  T. Ganz,et al.  DEFENSINS: NATURAL PEPTIDE ANTIBIOTICS IN HUMAN NEUTROPHILS , 1986 .

[131]  T. Tanaka,et al.  Mammalian chymotrypsin-like enzymes. Comparative reactivities of rat mast cell proteases, human and dog skin chymases, and human cathepsin G with peptide 4-nitroanilide substrates and with peptide chloromethyl ketone and sulfonyl fluoride inhibitors. , 1985, Biochemistry.

[132]  M. Selsted,et al.  Purification and antibacterial activity of antimicrobial peptides of rabbit granulocytes , 1984, Infection and immunity.

[133]  W. Shafer,et al.  Cationic antimicrobial proteins isolated from human neutrophil granulocytes in the presence of diisopropyl fluorophosphate , 1984, Infection and immunity.

[134]  M. Mayer.  Complement. Historical perspectives and some current issues. , 1984, Complement.

[135]  P. Ward.  CHEMOTAXIS OF MONONUCLEAR CELLS , 1968, The Journal of experimental medicine.

[136]  R. Good,et al.  A clinical and experimental study of the function of neutrophils in the inflammatory response. , 1958, The American journal of pathology.