The significance of the Papanicolaou smear diagnosis of low‐grade squamous intraepithelial lesion cannot exclude high‐grade squamous intraepithelial lesion

Cervical cytologic specimens that show a low‐grade squamous intraepithelial lesion (LSIL) occasionally contain a few cells that are suspicious for, but not diagnostic of, a high‐grade squamous intraepithelial lesion (HSIL). In such cases, a diagnosis of LSIL cannot exclude HSIL is rendered. The objective of the current study was to assess the positive predictive value (PPV) for HSIL in follow‐up cervical biopsies for these cases.

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