Understanding the sexome: measuring and reporting sex differences in gene systems.

The current male bias in biomedical research should be eliminated. The large sex differences in incidence and progression of diseases mean that sex-biased factors are an untapped source of factors that protect from disease. Greater understanding will come from intensified study of the "sexome," which is the sum of sex-biased effects on gene networks and cell systems. The global search for sites and mechanisms of sex-specific regulation in diverse tissues will provide unanticipated insights into physiological regulation and targets for novel therapies.

[1]  J. Broderick,et al.  The X-Chromosome Has a Different Pattern of Gene Expression in Women Compared With Men With Ischemic Stroke , 2012, Stroke.

[2]  W. C. Young,et al.  Organizing action of prenatally administered testosterone propionate on the tissues mediating mating behavior in the female guinea pig. , 1959, Endocrinology.

[3]  Roland Hetzer,et al.  Sexually dimorphic gene expression in the heart of mice and men , 2007, Journal of Molecular Medicine.

[4]  A. Arnold,et al.  Dosage compensation is less effective in birds than in mammals , 2007, Journal of biology.

[5]  David Haig,et al.  Sex-Specific Parent-of-Origin Allelic Expression in the Mouse Brain , 2010, Science.

[6]  G. Churchill,et al.  Quantitative trait locus analysis for obesity reveals multiple networks of interacting loci , 2006, Mammalian Genome.

[7]  A. Arnold,et al.  Tissue-specific expression and regulation of sexually dimorphic genes in mice. , 2006, Genome research.

[8]  D. Karasik,et al.  Contribution of Gender‐Specific Genetic Factors to Osteoporosis Risk , 2008, Annals of human genetics.

[9]  Eric E Schadt,et al.  Elucidating the role of gonadal hormones in sexually dimorphic gene coexpression networks. , 2009, Endocrinology.

[10]  V. Miller,et al.  Reporting of sex as a variable in cardiovascular studies using cultured cells , 2011, Biology of Sex Differences.

[11]  Carl W. Cotman,et al.  Gene expression changes in the course of normal brain aging are sexually dimorphic , 2008, Proceedings of the National Academy of Sciences.

[12]  Fabian J Theis,et al.  Discovery of Sexual Dimorphisms in Metabolic and Genetic Biomarkers , 2011, PLoS genetics.

[13]  Y. Gilad,et al.  An Evolutionarily Conserved Sexual Signature in the Primate Brain , 2008, PLoS genetics.

[14]  S. Scordilis,et al.  Gender dimorphism in the exercise-naïve murine skeletal muscle proteome , 2010, Cellular & Molecular Biology Letters.

[15]  L. Tarantino,et al.  Gender-influenced obesity QTLs identified in a cross involving the KK type II diabetes-prone mouse strain , 1999, Mammalian Genome.

[16]  J. Cheverud,et al.  Genetic Architecture of Adiposity and Organ Weight Using Combined Generation QTL Analysis , 2008, Obesity.

[17]  A. Arnold.  Promoting the understanding of sex differences to enhance equity and excellence in biomedical science , 2010, Biology of Sex Differences.

[18]  D. Aframian,et al.  Comparative proteomic analysis of human oral fluids according to gender and age. , 2010, Oral diseases.

[19]  R. Santhosh,et al.  Comparative proteomics of human male and female tears by two-dimensional electrophoresis. , 2011, Experimental eye research.

[20]  K. Bailey,et al.  Sex and Ethnic Differences in 47 Candidate Proteomic Markers of Cardiovascular Disease: The Mayo Clinic Proteomic Markers of Arteriosclerosis Study , 2010, PloS one.

[21]  J. Mogil,et al.  The case for the inclusion of female subjects in basic science studies of pain , 2005, Pain.

[22]  J. Broderick,et al.  Effects of Gender on Gene Expression in the Blood of Ischemic Stroke Patients , 2012, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[23]  M. McCarthy,et al.  The Epigenetics of Sex Differences in the Brain , 2009, The Journal of Neuroscience.

[24]  Joseph B Hiatt,et al.  Evidence for compensatory upregulation of expressed X-linked genes in mammals, Caenorhabditis elegans and Drosophila melanogaster , 2011, Nature Genetics.

[25]  G. J. Vries,et al.  Minireview: Sex differences in adult and developing brains: compensation, compensation, compensation. , 2004 .

[26]  B. Charlesworth,et al.  The evolution of chromosomal sex determination and dosage compensation , 1996, Current Biology.

[27]  C. Farber,et al.  Fine Mapping Reveals Sex Bias in Quantitative Trait Loci Affecting Growth, Skeletal Size and Obesity-Related Traits on Mouse Chromosomes 2 and 11 , 2007, Genetics.

[28]  A. Arnold.  The organizational–activational hypothesis as the foundation for a unified theory of sexual differentiation of all mammalian tissues , 2009, Hormones and Behavior.

[29]  J. Rinn,et al.  Major molecular differences between mammalian sexes are involved in drug metabolism and renal function. , 2004, Developmental cell.

[30]  Lorenzo Ferraro,et al.  Estrogen receptor alpha controls a gene network in luminal-like breast cancer cells comprising multiple transcription factors and microRNAs. , 2010, The American journal of pathology.

[31]  V. Beneš,et al.  Widespread estrogen-dependent repression of micrornas involved in breast tumor cell growth. , 2009, Cancer research.

[32]  R. Voskuhl.  Sex differences in autoimmune diseases , 2011, Biology of Sex Differences.

[33]  I. Zucker,et al.  Sex bias in neuroscience and biomedical research , 2011, Neuroscience & Biobehavioral Reviews.

[34]  V. Regitz-Zagrosek,et al.  Heart protein expression related to age and sex in mice and humans. , 2007, International journal of molecular medicine.

[35]  R. Myers,et al.  Gender-Specific Gene Expression in Post-Mortem Human Brain: Localization to Sex Chromosomes , 2004, Neuropsychopharmacology.

[36]  A. Arnold.  The end of gonad-centric sex determination in mammals. , 2012, Trends in genetics : TIG.

[37]  B. Molnár,et al.  Estradiol replacement alters expression of genes related to neurotransmission and immune surveillance in the frontal cortex of middle-aged, ovariectomized rats. , 2010, Endocrinology.

[38]  E. Schadt,et al.  Genetic and Genomic Analysis of a Fat Mass Trait with Complex Inheritance Reveals Marked Sex Specificity , 2006, PLoS genetics.

[39]  J. Cheverud,et al.  Sex dependent imprinting effects on complex traits in mice , 2008, BMC Evolutionary Biology.

[40]  J. Pankow,et al.  Genotype-by-sex interaction in the aetiology of type 2 diabetes mellitus: support for sex-specific quantitative trait loci in Hypertension Genetic Epidemiology Network participants , 2006, Diabetologia.

[41]  Bing Wang,et al.  Pleiotropic Patterns of Quantitative Trait Loci for 70 Murine Skeletal Traits , 2008, Genetics.

[42]  Yoav Gilad,et al.  Sex-specific genetic architecture of human disease , 2008, Nature Reviews Genetics.

[43]  S. Horvath,et al.  Sexually dimorphic gene expression in mouse brain precedes gonadal differentiation. , 2003, Brain research. Molecular brain research.