Trends in neovascular glaucoma management: Practice patterns of glaucoma and retina specialists in the United States

To characterize practice patterns between and within retina and glaucoma subspecialists treating neo- vascular glaucoma (NVG). Preliminary survey study consisting of 8-questions developed based on actual clinical cases presenting to our institution between June 2014 and June 2016. The survey was administered in the form of clinical vignettes and circulated electronically using Survey Monkey ©. to members of the American Glaucoma Society (AGS) and American Society of Retina Specialists (ASRS). 109 glaucoma and 130 retina specialists initiated the survey. For initial management of patients with good visual acuity (VA) and NVG, retina specialists preferred anti-VEGF therapy (P < 0.01) while glaucoma specialists preferred combined anti-VEGF and tube shunt surgery (P < 0.01). Following initial therapy in patients with good VA, glaucoma specialists preferred surgery (P < 0.01) and retina specialists preferred PRP (P < 0.01). In patients with poor VA, PRP and anti-VEGF were equally favored, with a preference for surgery by glaucoma specialists compared to retina specialists (P < 0.01). NVG is a complex problem within the field of ophthalmology that often requires management by both retina and glaucoma specialists. Agreement between both subspecialties for the use of anti-VEGF agents as first line treatment, either alone or in concert with other therapies was noted. Multiple differences exist in next step in therapy and long-term management. Future consensus panels may mitigate discrepancies in NVG management and work toward development of care paths for more efficient care delivery.

[1]  K. Lindsley,et al.  Anti-vascular endothelial growth factor for neovascular glaucoma. , 2020, The Cochrane database of systematic reviews.

[2]  Jennifer K. Sun,et al.  Five-Year Outcomes of Panretinal Photocoagulation vs Intravitreous Ranibizumab for Proliferative Diabetic Retinopathy: A Randomized Clinical Trial , 2018, JAMA ophthalmology.

[3]  M. Kinsella,et al.  Long-Term Outcome of Intravitreal Bevacizumab Followed by Ahmed Valve Implantation in the Management of Neovascular Glaucoma , 2018, Seminars in ophthalmology.

[4]  Qiuming Li,et al.  Ahmed Valves vs Trabeculectomy Combined with Pans Plana Vitrectomy for Neovascular Glaucoma with Vitreous Hemorrhage , 2017, European journal of ophthalmology.

[5]  Dabo Wang,et al.  Efficacy and safety of intravitreal ranibizumab with panretinal photocoagulation followed by trabeculectomy compared with Ahmed glaucoma valve implantation in neovascular glaucoma. , 2017, International journal of ophthalmology.

[6]  A. Aref Current management of glaucoma and vascular occlusive disease , 2016, Current opinion in ophthalmology.

[7]  P. Rosenfeld,et al.  Long-term outcomes of neovascular glaucoma treated with and without intravitreal bevacizumab , 2016, Eye.

[8]  A. Clark BMC Ophthalmology reviewer acknowledgement 2015 , 2016, BMC Ophthalmology.

[9]  Xiaodong Sun,et al.  Efficacy of intravitreal ranibizumab combined with Ahmed glaucoma valve implantation for the treatment of neovascular glaucoma , 2016, BMC Ophthalmology.

[10]  Jennifer K. Sun,et al.  Panretinal Photocoagulation vs Intravitreous Ranibizumab for Proliferative Diabetic Retinopathy: A Randomized Clinical Trial. , 2015, JAMA.

[11]  E. S. Arcieri,et al.  Efficacy and safety of intravitreal bevacizumab in eyes with neovascular glaucoma undergoing ahmed glaucoma valve implantation: 2‐year follow‐up , 2015, Acta ophthalmologica.

[12]  Jennifer K. Sun,et al.  Long-term effects of therapy with ranibizumab on diabetic retinopathy severity and baseline risk factors for worsening retinopathy. , 2015, Ophthalmology.

[13]  Khaled M. Fawzy,et al.  Efficacy of Intravitreal Bevacizumab With Panretinal Photocoagulation Followed by Ahmed Valve Implantation in Neovascular Glaucoma , 2013, Journal of glaucoma.

[14]  K. Lindsley,et al.  Anti-vascular endothelial growth factor for neovascular glaucoma. , 2013, The Cochrane database of systematic reviews.

[15]  J. Ehrlich,et al.  Long-term effects of ranibizumab on diabetic retinopathy severity and progression. , 2012, Archives of ophthalmology.

[16]  Eun Suk Lee,et al.  Surgical Results of Ahmed Valve Implantation With Intraoperative Bevacizumab Injection in Patients With Neovascular Glaucoma , 2012, Journal of glaucoma.

[17]  A. Aref Management of immediate and sustained intraocular pressure rise associated with intravitreal antivascular endothelial growth factor injection therapy , 2012, Current opinion in ophthalmology.

[18]  M. Yaseri,et al.  Intravitreal Bevacizumab for Neovascular Glaucoma: A Randomized Controlled Trial , 2009, Journal of glaucoma.

[19]  A. Şahin,et al.  A Comparative Study Between Diode Laser Cyclophotocoagulation and the Ahmed Glaucoma Valve Implant in Neovascular Glaucoma: A Long-term Follow-up , 2009, Journal of glaucoma.

[20]  W. Tasman,et al.  COMBINATION INTRAVITREAL BEVACIZUMAB/PANRETINAL PHOTOCOAGULATION VERSUS PANRETINAL PHOTOCOAGULATION ALONE IN THE TREATMENT OF NEOVASCULAR GLAUCOMA , 2008, Retina.

[21]  S. Hayreh,et al.  Argon laser panretinal photocoagulation in ischemic central retinal vein occlusion , 1990, Graefe's Archive for Clinical and Experimental Ophthalmology.

[22]  M. Ivanišević,et al.  Comparison between efficacy of full- and mild-scatter (panretinal) photocoagulation on the course of diabetic rubeosis iridis. , 1993, Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift fur Augenheilkunde.

[23]  G. Brown,et al.  Neovascular Glaucoma: Etiologic Considerations , 1984 .

[24]  R. Ritch,et al.  Long-term results of valve implants in filtering surgery for eyes with neovascular glaucoma. , 1983, American journal of ophthalmology.

[25]  R. Bartholomew,et al.  Implants for draining neovascular glaucoma. , 1977, The British journal of ophthalmology.