Methodological improvements in voxel‐based analysis of diffusion tensor images: Applications to study the impact of apolipoprotein E on white matter integrity

To identify regional differences in apparent diffusion coefficient (ADC) and fractional anisotropy (FA) using customized preprocessing before voxel‐based analysis (VBA) in 14 normal subjects with the specific genes that decrease (apolipoprotein [APO] E ε2) and that increase (APOE ε4) the risk of Alzheimer's disease.

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