Three‐dimensional morphological revealing of human placental villi with common obstetric complications via optical coherence tomography

Abstract Placental villi play a vital role in human fetal development, acting as the bridge of material exchange between the maternal and fetal. The abnormal morphology of placental villi is closely related to placental circulation disorder and pregnancy complications. Revealing placental villi three‐dimensional (3D) morphology of common obstetric complications and healthy pregnancies provides a new perspective for studying the role of the placenta and its villi in the development of pregnancy diseases. In this study, we established a noninvasive, high‐resolution 3D imaging platform via optical coherence tomography to reveal placental villi 3D morphological information of diseased and normal placentae. For the first time, 3D morphologies of placental villous tree structures in common obstetric complications were quantitatively revealed and corresponding 3D information could visualize the morphological characteristics of the placental villous tree from a more intuitive perspective, providing helpful information to the study of fetal development, feto‐maternal material exchange, and gestational complications treatment.

[1]  Guangming Ni,et al.  Sm-Net OCT: a deep-learning-based speckle-modulating optical coherence tomography. , 2021, Optics express.

[2]  G. Poologasundarampillai,et al.  A massively multi-scale approach to characterizing tissue architecture by synchrotron micro-CT applied to the human placenta , 2021, Journal of the Royal Society Interface.

[3]  D. Schust,et al.  Placental structural abnormalities in gestational diabetes and when they develop: A scoping review. , 2021, Placenta.

[4]  L. Hui,et al.  Reduced growth velocity from the mid-trimester is associated with placental insufficiency in fetuses born at a normal birthweight , 2020, BMC Medicine.

[5]  M. Westwood,et al.  Tracking placental development in health and disease , 2020, Nature Reviews Endocrinology.

[6]  Lin Liu,et al.  Detection and compensation of dispersion mismatch for frequency-domain optical coherence tomography based on A-scan's spectrogram. , 2020, Optics express.

[7]  Linbo Liu,et al.  Towards Indicating Human Skin State In Vivo Using Geometry-Dependent Spectroscopic Contrast Imaging , 2020, IEEE Photonics Technology Letters.

[8]  E. Jauniaux,et al.  Oxygen and development of the human placenta. , 2020, Reproduction.

[9]  Rohan M. Lewis,et al.  Serial block‐face scanning electron microscopy reveals novel intercellular connections in human term placental microvasculature , 2020, Journal of anatomy.

[10]  J. Kingdom,et al.  The Placental Basis of Fetal Growth Restriction. , 2020, Obstetrics and gynecology clinics of North America.

[11]  Glenn O. Brown,et al.  Baseline quantitative histology in therapeutics trials reveals villus atrophy in most patients with coeliac disease who appear well controlled on gluten‐free diet , 2020 .

[12]  Maria A. Zuluaga,et al.  Micro-CT and histological investigation of the spatial pattern of feto-placental vascular density , 2019, Placenta.

[13]  D. Charnock-Jones,et al.  Three-dimensional morphological analysis of placental terminal villi , 2019, Interface Focus.

[14]  Linbo Liu,et al.  Understanding optical reflectance contrast for real‐time characterization of epithelial precursor lesions , 2019, Bioengineering & translational medicine.

[15]  R. G. Wilkerson,et al.  Hypertensive Disorders of Pregnancy. , 2019, Emergency medicine clinics of North America.

[16]  L. Magee,et al.  The hypertensive disorders of pregnancy: ISSHP classification, diagnosis & management recommendations for international practice. , 2018, Pregnancy hypertension.

[17]  Abdulrhman Saleh Dairi,et al.  Quantitative Morphometric Study of the Chorionic Villi in Hypertensive Mothers , 2017 .

[18]  M. Rice,et al.  Neonatal Morbidity of Small- and Large-for-Gestational-Age Neonates Born at Term in Uncomplicated Pregnancies. , 2017, Obstetrics and gynecology.

[19]  M. Mallika,et al.  MORPHOLOGICAL AND HISTOLOGICAL VARIATIONS OF HUMAN PLACENTA IN HYPERTENSIVE DISORDERS OF PREGNANCY , 2017 .

[20]  K. Thangaraj,et al.  Propagation of pure fetal and maternal mesenchymal stromal cells from terminal chorionic villi of human term placenta , 2015, Scientific Reports.

[21]  Johannes E. Schindelin,et al.  Fiji: an open-source platform for biological-image analysis , 2012, Nature Methods.

[22]  A. Elfayomy,et al.  Structural analysis of human placental stem and terminal villi from normal and idiopathic growth restricted pregnancies , 2012, Journal of Molecular Histology.

[23]  B. Huppertz,et al.  The anatomy of the normal placenta , 2008, Journal of Clinical Pathology.

[24]  A. Baschat,et al.  Fetal growth restriction. , 2008, Seminars in perinatology.

[25]  S. Hauguel-de Mouzon,et al.  The Human Placenta in Gestational Diabetes Mellitus , 2007, Diabetes Care.

[26]  D. Barker,et al.  Adult Consequences of Fetal Growth Restriction , 2006, Clinical obstetrics and gynecology.

[27]  B Huppertz,et al.  Development of the placental villous tree and its consequences for fetal growth. , 2000, European journal of obstetrics, gynecology, and reproductive biology.

[28]  J. Fujimoto,et al.  Determination of the refractive index of highly scattering human tissue by optical coherence tomography. , 1995, Optics letters.

[29]  K. Benirschke,et al.  Pathology of the Human Placenta , 1974, Springer New York.

[30]  Rohan M. Lewis,et al.  Development of the Human Placental Villus , 2014 .

[31]  G. Burton,et al.  Basic Structure of the Villous Trees , 2012 .