In vivo evaluation of human skin anisotropy by polarization-sensitive optical coherence tomography

Abstract We performed an in vivo three-dimensional analysis of anisotropic changes in the dermal birefringence of mechanically deformed human skin using polarization-sensitive optical coherence tomography (PS-OCT). The papillary-dermal birefringence of the forehead increased significantly when the skin was shrunk parallel to the body axis, and decreased significantly when the skin was shrunk perpendicular to the body axis. En-face images of the papillary-dermal birefringence revealed variations among individual subjects, and that both shrinking parallel to and stretching in perpendicular to the body axis promoted the formation of macro rope-like birefringent domains. We found that PS-OCT is useful for understanding anisotropic properties of collagen structure in the skin.

[1]  Beop-Min Kim,et al.  Polarization-dependent optical second-harmonic imaging of a rat-tail tendon. , 2002, Journal of biomedical optics.

[2]  Gary Chinga,et al.  Quantification of the 3D microstructure of SC surfaces , 2007, Journal of microscopy.

[3]  A F Borges,et al.  Relaxed skin tension lines (RSTL) versus other skin lines. , 1984, Plastic and reconstructive surgery.

[4]  Brown Ia.  Scanning electron microscopy of human dermal fibrous tissue. , 1972 .

[5]  Takeshi Yasui,et al.  Observation of dermal collagen fiber in wrinkled skin using polarization-resolved second-harmonic-generation microscopy. , 2009, Optics express.

[6]  Barry Cense,et al.  In vivo birefringence and thickness measurements of the human retinal nerve fiber layer using polarization-sensitive optical coherence tomography. , 2004, Journal of biomedical optics.

[7]  J. Nelson,et al.  In vivo burn depth determination by high-speed fiber-based polarization sensitive optical coherence tomography. , 2001, Journal of biomedical optics.

[8]  Sören Jaspers,et al.  Rapid in vivo measurement of the topography of human skin by active image triangulation using a digital micromirror device , 1999 .

[9]  C. Kraissl.  THE SELECTION OF APPROPRIATE LINES FOR ELECTIVE SURGICAL INCISIONS , 1951, Plastic and reconstructive surgery.

[10]  M. J. Grove,et al.  Optical profilometry: an objective method for quantification of facial wrinkles. , 1989, Journal of the American Academy of Dermatology.

[11]  K. Langer.  On the anatomy and physiology of the skin , 1978 .

[12]  I A Brown,et al.  Scanning electron microscopy of human dermal fibrous tissue. , 1972, Journal of anatomy.

[13]  Toyohiko Yatagai,et al.  In vivo three-dimensional birefringence analysis shows collagen differences between young and old photo-aged human skin. , 2008, The Journal of investigative dermatology.

[14]  T. Yatagai,et al.  Fiber-based polarization-sensitive Fourier domain optical coherence tomography using B-scan-oriented polarization modulation method. , 2006, Optics express.

[15]  Masahiro Ito,et al.  Ex vivo and in vivo second-harmonic-generation imaging of dermal collagen fiber in skin: comparison of imaging characteristics between mode-locked Cr:forsterite and Ti:sapphire lasers. , 2009, Applied optics.

[16]  M. Ferguson,et al.  The dynamic rotation of Langer's lines on facial expression. , 2007, Journal of plastic, reconstructive & aesthetic surgery : JPRAS.

[17]  Toyohiko Yatagai,et al.  Imaging polarimetry in age-related macular degeneration. , 2008, Investigative ophthalmology & visual science.

[18]  K. Langer,et al.  On the anatomy and physiology of the skin: I. The cleavability of the cutis , 1978 .

[19]  Yoshiaki Yasuno,et al.  Relationship between dermal birefringence and the skin surface roughness of photoaged human skin. , 2009, Journal of biomedical optics.

[20]  Yoshiaki Yasuno,et al.  Polarization sensitive corneal and anterior segment swept-source optical coherence tomography , 2010, BiOS.

[21]  G. Piérard,et al.  Microanatomy of the dermis in relation to relaxed skin tension lines and Langer's lines. , 1987, The American Journal of dermatopathology.

[22]  A F Borges,et al.  Relaxed skin tension lines. , 1989, Dermatologic clinics.

[23]  C. V. van Noorden,et al.  Rapid alignment of collagen fibers in the dermis of undermined and not undermined skin stretched with a skin-stretching device. , 2002, Plastic and reconstructive surgery.

[24]  Y. Yasuno,et al.  Polarization-sensitive swept-source optical coherence tomography with continuous source polarization modulation. , 2008, Optics express.

[25]  Chi-Kuang Sun,et al.  In vivo harmonic generation biopsy of human skin. , 2009, Journal of biomedical optics.

[26]  L. Phillips,et al.  Langer's lines: to use or not to use. , 1999, Plastic and reconstructive surgery.

[27]  H Sakai,et al.  Cleavage lines of the skin. , 1986, Bibliotheca anatomica.

[28]  R M Kenedi,et al.  The mobile micro‐architecture of dermal collagen: A bio‐engineering study , 1965, The British journal of surgery.

[29]  T Fujimura,et al.  Global and systematic demonstration for the practical usage of a direct in vivo measurement system to evaluate wrinkles , 2007, International journal of cosmetic science.

[30]  V. Wright,et al.  The directional effects of skin. A bio-engineering study of skin with particular reference to Langer's lines. , 1966, The Journal of investigative dermatology.

[31]  Egbert Lenderink,et al.  Characterization of age-related effects in human skin: A comparative study that applies confocal laser scanning microscopy and optical coherence tomography. , 2004, Journal of biomedical optics.

[32]  P. Byers,et al.  Structure of the dermal matrix during development and in the adult. , 1982, The Journal of investigative dermatology.

[33]  Haishan Zeng,et al.  In vivo video rate multiphoton microscopy imaging of human skin. , 2011, Optics letters.

[34]  Barry Cense,et al.  Advances in optical coherence tomography imaging for dermatology. , 2004, The Journal of investigative dermatology.

[35]  Takeshi Yasui,et al.  Characterization of collagen orientation in human dermis by two-dimensional second-harmonic-generation polarimetry. , 2004, Journal of biomedical optics.

[36]  Toyohiko Yatagai,et al.  Phase retardation measurement of retinal nerve fiber layer by polarization-sensitive spectral-domain optical coherence tomography and scanning laser polarimetry. , 2008, Journal of biomedical optics.