Viral-mediated Ntf3 overexpression disrupts innervation and hearing in nondeafened guinea pig cochleae

[1]  G. Dusting,et al.  Gene Delivery by Subconjunctival Injection of Adenovirus in Rats: A Study of Local Distribution, Transgene Duration and Safety , 2015, PloS one.

[2]  M. Liberman,et al.  Synaptopathy in the noise-exposed and aging cochlea: Primary neural degeneration in acquired sensorineural hearing loss , 2015, Hearing Research.

[3]  S. Roy,et al.  Cochlear gene transfer mediated by adeno‐associated virus: Comparison of two surgical approaches , 2015, The Laryngoscope.

[4]  Y. Raphael,et al.  Differential Effects of AAV.BDNF and AAV.Ntf3 in the Deafened Adult Guinea Pig Ear , 2015, Scientific Reports.

[5]  Leslie D. Liberman,et al.  Dynamics of cochlear synaptopathy after acoustic overexposure , 2015, Journal of the Association for Research in Otolaryngology.

[6]  S. Gray,et al.  Viral expression cassette elements to enhance transgene target specificity and expression in gene therapy. , 2015, Discovery medicine.

[7]  A. Wise,et al.  Treating hearing disorders with cell and gene therapy , 2014, Journal of neural engineering.

[8]  M. Liberman,et al.  Neurotrophin-3 regulates ribbon synapse density in the cochlea and induces synapse regeneration after acoustic trauma , 2014, eLife.

[9]  Kristina E. Froud,et al.  Close-Field Electroporation Gene Delivery Using the Cochlear Implant Electrode Array Enhances the Bionic Ear , 2014, Science Translational Medicine.

[10]  Y. Raphael,et al.  Connexin 26 null mice exhibit spiral ganglion degeneration that can be blocked by BDNF gene therapy , 2014, Hearing Research.

[11]  Jianjun Wang,et al.  Virally-expressed connexin26 restores gap junction function in the cochlea of conditional Gjb2 knockout mice , 2013, Gene Therapy.

[12]  M. Liberman,et al.  Noise-induced cochlear neuropathy is selective for fibers with low spontaneous rates. , 2013, Journal of neurophysiology.

[13]  Y. Raphael,et al.  Gene therapy for the inner ear , 2013, Hearing Research.

[14]  A. Wise,et al.  Neurotrophin Gene Therapy for Sustained Neural Preservation after Deafness , 2012, PloS one.

[15]  Y. Raphael,et al.  BDNF gene therapy induces auditory nerve survival and fiber sprouting in deaf Pou4f3 mutant mice , 2012, Scientific Reports.

[16]  R. Edwards,et al.  Restoration of Hearing in the VGLUT3 Knockout Mouse Using Virally Mediated Gene Therapy , 2012, Neuron.

[17]  C. Dunbar,et al.  Pharmacological Modulation of Humoral Immunity in a Nonhuman Primate Model of AAV Gene Transfer for Hemophilia B , 2012, Molecular therapy : the journal of the American Society of Gene Therapy.

[18]  B. Kaspar,et al.  TrkB and TrkC agonist antibodies improve function, electrophysiologic and pathologic features in TremblerJ mice , 2010, Experimental Neurology.

[19]  A. Wise,et al.  Effects of localized neurotrophin gene expression on spiral ganglion neuron resprouting in the deafened cochlea. , 2010, Molecular therapy : the journal of the American Society of Gene Therapy.

[20]  Y. Raphael,et al.  Transgenic BDNF induces nerve fiber regrowth into the auditory epithelium in deaf cochleae , 2010, Experimental Neurology.

[21]  S. Weger,et al.  Viral vectors for gene transfer: current status of gene therapeutics. , 2010, Handbook of experimental pharmacology.

[22]  M. Liberman,et al.  Adding Insult to Injury: Cochlear Nerve Degeneration after “Temporary” Noise-Induced Hearing Loss , 2009, The Journal of Neuroscience.

[23]  Z. Pan,et al.  Evaluation of the adeno-associated virus mediated long-term expression of channelrhodopsin-2 in the mouse retina , 2009, Molecular vision.

[24]  R. Altschuler,et al.  Deafferentiation‐associated changes in afferent and efferent processes in the guinea pig cochlea and afferent regeneration with chronic intrascalar brain‐derived neurotrophic factor and acidic fibroblast growth factor , 2008, The Journal of comparative neurology.

[25]  Donald L. Swiderski,et al.  Cochlear implants and ex vivo BDNF gene therapy protect spiral ganglion neurons , 2007, Hearing Research.

[26]  G. Rebillard,et al.  Coxsackie adenovirus receptor and alpha nu beta3/alpha nu beta5 integrins in adenovirus gene transfer of rat cochlea. , 2007, Gene therapy.

[27]  G. Rebillard,et al.  Coxsackie adenovirus receptor and ανβ3/ανβ5 integrins in adenovirus gene transfer of rat cochlea , 2007, Gene Therapy.

[28]  L. Davies,et al.  Long-term persistence of gene expression from adeno-associated virus serotype 5 in the mouse airways , 2006, Gene Therapy.

[29]  M. Walger,et al.  Diagnostik und Therapie der auditorischen Synaptopathie/Neuropathie , 2006, HNO.

[30]  A. Wise,et al.  Resprouting and survival of guinea pig cochlear neurons in response to the administration of the neurotrophins brain‐derived neurotrophic factor and neurotrophin‐3 , 2005, The Journal of comparative neurology.

[31]  A. Egner,et al.  Hair cell synaptic ribbons are essential for synchronous auditory signalling , 2005, Nature.

[32]  K. Lundstrom.  Gene Therapy Applications of Viral Vectors , 2004, Technology in cancer research & treatment.

[33]  B. J. Baumgartner,et al.  Neurotrophin-3 Expressed In Situ Induces Axonal Plasticity in the Adult Injured Spinal Cord , 2003, The Journal of Neuroscience.

[34]  K. Kawamoto,et al.  Gene transfer into supporting cells of the organ of Corti , 2002, Hearing Research.

[35]  R. Frisina,et al.  Neurotrophin-3 transduction attenuates cisplatin spiral ganglion neuron ototoxicity in the cochlea. , 2002, Molecular therapy : the journal of the American Society of Gene Therapy.

[36]  L. Moldawer,et al.  Application of gene therapy to acute inflammatory diseases. , 1999, Shock.

[37]  S. Leong,et al.  Effects of BDNF and NT-3 on hair cell survival in guinea pig cochlea damaged by kanamycin treatment. , 1999, Neuroreport.

[38]  J. R. Holt,et al.  Functional expression of exogenous proteins in mammalian sensory hair cells infected with adenoviral vectors. , 1999, Journal of neurophysiology.

[39]  Y. Raphael,et al.  Hair cell protection from aminoglycoside ototoxicity by adenovirus-mediated overexpression of glial cell line-derived neurotrophic factor. , 1999, Human gene therapy.

[40]  J. Puel,et al.  Pathophysiology of the glutamatergic synapses in the cochlea. , 1993, Acta oto-laryngologica.

[41]  D. D. Greenwood.  Critical Bandwidth and the Frequency Coordinates of the Basilar Membrane , 1961 .