A Large-Scale Genome-Wide Gene-Gene Interaction Study of Lung Cancer Susceptibility in Europeans With a Trans-Ethnic Validation in Asians

[1]  Hongbing Shen,et al.  A multi-omics study links TNS3 and SEPT7 to long-term former smoking NSCLC survival , 2021, npj Precision Oncology.

[2]  P. Collins,et al.  Discrimination of single-point mutations in unamplified genomic DNA via Cas9 immobilized on a graphene field-effect transistor , 2021, Nature Biomedical Engineering.

[3]  M. Cabana,et al.  Screening for Lung Cancer: US Preventive Services Task Force Recommendation Statement. , 2021, JAMA.

[4]  Xiaopei Shen,et al.  Therapeutic targeting of FOS in mutant TERT cancers through removing TERT suppression of apoptosis via regulating survivin and TRAIL-R2 , 2021, Proceedings of the National Academy of Sciences.

[5]  Daniel J. Gaffney,et al.  Genome-wide meta-analysis, fine-mapping, and integrative prioritization implicate new Alzheimer’s disease risk genes , 2021, Nature Genetics.

[6]  L. Kiemeney,et al.  Assessing Lung Cancer Absolute Risk Trajectory Based on a Polygenic Risk Model , 2021, Cancer Research.

[7]  A. Jemal,et al.  Cancer Statistics, 2021 , 2021, CA: a cancer journal for clinicians.

[8]  S. Duffy,et al.  Liverpool Lung Project lung cancer risk stratification model: calibration and prospective validation , 2020, Thorax.

[9]  M. Oudkerk,et al.  Lung cancer LDCT screening and mortality reduction — evidence, pitfalls and future perspectives , 2020, Nature Reviews Clinical Oncology.

[10]  Shing Wan Choi,et al.  Tutorial: a guide to performing polygenic risk score analyses , 2020, Nature Protocols.

[11]  S. A. Lambert,et al.  The Polygenic Score Catalog: an open database for reproducibility and systematic evaluation , 2020, medRxiv.

[12]  E. Guallar,et al.  Chronic obstructive pulmonary disease and lung cancer incidence in never smokers: a cohort study , 2020, Thorax.

[13]  M. Esteller,et al.  Independent Validation of Early-Stage Non-Small Cell Lung Cancer Prognostic Scores Incorporating Epigenetic and Transcriptional Biomarkers With Gene-Gene Interactions and Main Effects , 2020, Chest.

[14]  Harry J de Koning,et al.  Reduced Lung-Cancer Mortality with Volume CT Screening in a Randomized Trial. , 2020, The New England journal of medicine.

[15]  M. He,et al.  Daily cooking duration and its joint effects with genetic polymorphisms on lung cancer incidence: Results from a Chinese prospective cohort study. , 2019, Environmental research.

[16]  Hongbing Shen,et al.  Identification of risk loci and a polygenic risk score for lung cancer: a large-scale prospective cohort study in Chinese populations. , 2019, The Lancet. Respiratory medicine.

[17]  K. Fong,et al.  Chronic obstructive pulmonary disease (COPD) and lung cancer: common pathways for pathogenesis. , 2019, Journal of thoracic disease.

[18]  Z. Ling,et al.  Deregulation of CSMD1 targeted by microRNA-10b drives gastric cancer progression through the NF-κB pathway , 2019, International journal of biological sciences.

[19]  H. Morgenstern,et al.  Lung Cancer Risk in Never-Smokers of European Descent is Associated With Genetic Variation in the 5p15.33 TERT-CLPTM1Ll Region. , 2019, Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer.

[20]  L. Kiemeney,et al.  Fine mapping of MHC region in lung cancer highlights independent susceptibility loci by ethnicity , 2018, Nature Communications.

[21]  L. Wain,et al.  Identification of susceptibility pathways for the role of chromosome 15q25.1 in modifying lung cancer risk , 2018, Nature Communications.

[22]  V. Bansal,et al.  Genome-wide association study results for educational attainment aid in identifying genetic heterogeneity of schizophrenia , 2018, Nature Communications.

[23]  Selecting lung cancer screenees using risk prediction models-where do we go from here. , 2018, Translational lung cancer research.

[24]  P. Mazzone,et al.  Screening for Lung Cancer: CHEST Guideline and Expert Panel Report , 2018, Chest.

[25]  Calliope A. Dendrou,et al.  HLA variation and disease , 2018, Nature Reviews Immunology.

[26]  Witold Rzyman,et al.  European position statement on lung cancer screening. , 2017, The Lancet. Oncology.

[27]  Lars G Fritsche,et al.  Efficiently controlling for case-control imbalance and sample relatedness in large-scale genetic association studies , 2017, Nature Genetics.

[28]  Y. Bossé,et al.  A Decade of GWAS Results in Lung Cancer , 2017, Cancer Epidemiology, Biomarkers & Prevention.

[29]  William S. Bush,et al.  Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes , 2017, Nature Genetics.

[30]  Jiawei Shen,et al.  Genome‐wide two‐locus interaction analysis identifies multiple epistatic SNP pairs that confer risk of prostate cancer: A cross‐population study , 2017, International journal of cancer.

[31]  Seunggeun Lee,et al.  A fast and accurate algorithm to test for binary phenotypes and its application to PheWAS , 2017, bioRxiv.

[32]  Tangchun Wu,et al.  The associations of TERT-CLPTM1L variants and TERT mRNA expression with the prognosis of early stage non-small cell lung cancer , 2016, Cancer Gene Therapy.

[33]  Dennis J. Hazelett,et al.  The OncoArray Consortium: A Network for Understanding the Genetic Architecture of Common Cancers , 2016, Cancer Epidemiology, Biomarkers & Prevention.

[34]  N. Eriksson,et al.  Genome-wide analysis identifies 12 loci influencing human reproductive behavior , 2016 .

[35]  Krista A. Zanetti,et al.  Genome-wide association study confirms lung cancer susceptibility loci on chromosomes 5p15 and 15q25 in an African-American population. , 2016, Lung cancer.

[36]  Shane A. McCarthy,et al.  Reference-based phasing using the Haplotype Reference Consortium panel , 2016, Nature Genetics.

[37]  C. la Vecchia,et al.  Risk factors for lung cancer worldwide , 2016, European Respiratory Journal.

[38]  G. Parmigiani,et al.  Familial Risk and Heritability of Cancer Among Twins in Nordic Countries. , 2016, JAMA.

[39]  Xihong Lin,et al.  Genome-wide Gene–Asbestos Exposure Interaction Association Study Identifies a Common Susceptibility Variant on 22q13.31 Associated with Lung Cancer Risk , 2015, Cancer Epidemiology, Biomarkers & Prevention.

[40]  G. Kempermann Faculty Opinions recommendation of Human genomics. The Genotype-Tissue Expression (GTEx) pilot analysis: multitissue gene regulation in humans. , 2015 .

[41]  M. Resh,et al.  Hedgehog Acyltransferase as a target in estrogen receptor positive, HER2 amplified, and tamoxifen resistant breast cancer cells , 2015, Molecular Cancer.

[42]  P. Elliott,et al.  UK Biobank: An Open Access Resource for Identifying the Causes of a Wide Range of Complex Diseases of Middle and Old Age , 2015, PLoS medicine.

[43]  P. Brennan,et al.  Effect of Occupational Exposures on Lung Cancer Susceptibility: A Study of Gene–Environment Interaction Analysis , 2015, Cancer Epidemiology, Biomarkers & Prevention.

[44]  Jian Huang,et al.  Group descent algorithms for nonconvex penalized linear and logistic regression models with grouped predictors , 2012, Statistics and Computing.

[45]  G. Beatty,et al.  Immune Escape Mechanisms as a Guide for Cancer Immunotherapy , 2014, Clinical Cancer Research.

[46]  Tyler J. VanderWeele,et al.  A Tutorial on Interaction , 2014 .

[47]  K. Straif,et al.  Is previous respiratory disease a risk factor for lung cancer? , 2014, American journal of respiratory and critical care medicine.

[48]  Hongbing Shen,et al.  A genome-wide gene-environment interaction analysis for tobacco smoke and lung cancer susceptibility. , 2014, Carcinogenesis.

[49]  William Wheeler,et al.  Rare variants of large effect in BRCA2 and CHEK2 affect risk of lung cancer , 2014, Nature Genetics.

[50]  Julian Peto,et al.  A large-scale assessment of two-way SNP interactions in breast cancer susceptibility using 46,450 cases and 42,461 controls from the breast cancer association consortium. , 2014, Human molecular genetics.

[51]  Yang Zhao,et al.  A genome-wide gene-gene interaction analysis identifies an epistatic gene pair for lung cancer susceptibility in Han Chinese. , 2014, Carcinogenesis.

[52]  M. You,et al.  Crr9/clptm1l Regulates Cell Survival Signaling and Is Required for Ras Transformation and Lung Tumorigenesis Figures: 7 Main Text and 7 Supplementary , 2022 .

[53]  Kai-Ping Chang,et al.  How Genome-Wide SNP-SNP Interactions Relate to Nasopharyngeal Carcinoma Susceptibility , 2013, PloS one.

[54]  C. Carlson,et al.  Genome-Wide Search for Gene-Gene Interactions in Colorectal Cancer , 2012, PloS one.

[55]  B. Qian,et al.  Genome-wide association analysis identifies new lung cancer susceptibility loci in never-smoking women in Asia , 2012, Nature Genetics.

[56]  Eurie L. Hong,et al.  Annotation of functional variation in personal genomes using RegulomeDB , 2012, Genome research.

[57]  Yang Zhao,et al.  Influence of common genetic variation on lung cancer risk: meta-analysis of 14 900 cases and 29 485 controls , 2012, Human molecular genetics.

[58]  Attila Gyenesei,et al.  BiForce Toolbox: powerful high-throughput computational analysis of gene–gene interactions in genome-wide association studies , 2012, Nucleic Acids Res..

[59]  Guangchuang Yu,et al.  clusterProfiler: an R package for comparing biological themes among gene clusters. , 2012, Omics : a journal of integrative biology.

[60]  Jianfeng Xu,et al.  Genome-wide two-locus epistasis scans in prostate cancer using two European populations , 2012, Human Genetics.

[61]  E. Lander,et al.  The mystery of missing heritability: Genetic interactions create phantom heritability , 2012, Proceedings of the National Academy of Sciences.

[62]  Manolis Kellis,et al.  HaploReg: a resource for exploring chromatin states, conservation, and regulatory motif alterations within sets of genetically linked variants , 2011, Nucleic Acids Res..

[63]  M. Spitz,et al.  Novel genetic variants in the chromosome 5p15.33 region associate with lung cancer risk. , 2011, Carcinogenesis.

[64]  W. Willett,et al.  Large-scale exploration of gene-gene interactions in prostate cancer using a multistage genome-wide association study. , 2011, Cancer research.

[65]  A. Ashworth,et al.  Genetic Interactions in Cancer Progression and Treatment , 2011, Cell.

[66]  Judy H. Cho,et al.  Finding the missing heritability of complex diseases , 2009, Nature.

[67]  R. Houlston,et al.  The TERT-CLPTM1L lung cancer susceptibility variant associates with higher DNA adduct formation in the lung. , 2009, Carcinogenesis.

[68]  Jack A. Taylor,et al.  SNPinfo: integrating GWAS and candidate gene information into functional SNP selection for genetic association studies , 2009, Nucleic Acids Res..

[69]  Simon Heath,et al.  Lung cancer susceptibility locus at 5p15.33 , 2008, Nature Genetics.

[70]  Joshua M. Korn,et al.  Integrated genotype calling and association analysis of SNPs, common copy number polymorphisms and rare CNVs , 2008, Nature Genetics.

[71]  W. Bodmer,et al.  Common and rare variants in multifactorial susceptibility to common diseases , 2008, Nature Genetics.

[72]  Jichun Chen,et al.  Telomerase: not just for the elongation of telomeres. , 2006, BioEssays : news and reviews in molecular, cellular and developmental biology.

[73]  J. Luketich,et al.  Comparison of mutations in the p53 and K-ras genes in lung carcinomas from smoking and nonsmoking women. , 1999, Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.

[74]  Y. Benjamini,et al.  Controlling the false discovery rate: a practical and powerful approach to multiple testing , 1995 .

[75]  L. Ger,et al.  [Risk factors of lung cancer]. , 1992, Journal of the Formosan Medical Association = Taiwan yi zhi.