Introduction to Microwave Chemistry

For more than a century heterocycles have constituted one of the largest areas of research in organic chemistry. The heterocyclic moieties are of exceptional interest in the pharmaceutical industry as they make up a core part of several drugs. The importance of heterocycles provides a significant basis for the development of new methods for their synthesis. Further, due to the strengthening environmental regulations and safety concerns, the industries are in need of new innovative, environmental friendly alternate routes for synthesizing the therapeutic and pharmacological important heterocyclics are desired. This environmentally benign synthesis can be easily designed using microwave methodology. The microwaves induce rapid heating and avoid the harsh classical conditions, resulting in the formation of cleaner products. The first chapter thus deals with the microwave theory, latest developments in instrumentation technology, the various microwave technologies used for synthesis.

[1]  J. Tierney,et al.  Microwave assisted organic synthesis-a review , 2001 .

[2]  A. Loupy Microwaves in organic synthesis , 2002 .

[3]  Shweta Sharma,et al.  GREEN CHEMISTRY APPROACH TO THE SUSTAINABLE ADVANCEMENT TO THE SYNTHESIS OF HETEROCYCLIC CHEMISTRY , 2008 .

[4]  Jean-Louis Luche,et al.  Microwave activation in phase transfer catalysis , 1999 .

[5]  J. Tierney,et al.  Microwave Assisted Organic Synthesis , 2005 .

[6]  Werner Bonrath,et al.  Microwave assisted synthesis – a critical technology overview , 2004 .

[7]  D. Villemin,et al.  Domestic microwave ovens in the laboratory , 1991 .

[8]  Q. Guo,et al.  Syntheses of Heterocyclic Compounds under Microwave Irradiation , 2004 .

[9]  David Adam,et al.  Microwave chemistry: Out of the kitchen , 2003, Nature.

[10]  C. Kappe,et al.  Microwaves in Organic and Medicinal Chemistry , 2012 .

[11]  A. Moreno,et al.  CYCLOADDITIONS UNDER MICROWAVE IRRADIATION CONDITIONS: METHODS AND APPLICATIONS , 2000 .

[12]  John R. Jones,et al.  Microwave-enhanced radiochemistry , 2000 .

[13]  B. Banik,et al.  MORE Chemistry for Less Pollution: Applications for Process Development , 2002 .

[14]  Rajender S. Varma,et al.  Solvent-free organic syntheses. using supported reagents and microwave irradiation , 1999 .

[15]  Anders Hallberg,et al.  Microwave-accelerated homogeneous catalysis in organic chemistry. , 2002, Accounts of chemical research.

[16]  R. Gedye,et al.  The use of microwave ovens for rapid organic synthesis , 1986 .

[17]  A. Petit,et al.  Re-examination of Microwave-Induced Synthesis of Phthalimides , 2000 .

[18]  Helen E Blackwell,et al.  Out of the oil bath and into the oven--microwave-assisted combinatorial chemistry heats up. , 2003, Organic & biomolecular chemistry.