Carcinoid tumors of the lung and coexistence of malign epithelial tumors Akciğerin karsinoid tümörleri ve malign epitelyal tümör birlikteliği

Amac: Bu calismada epitelyal tumorun eslik ettigi akciger karsinoid tumorlu ve cerrahi olarak tedavi edilen bes olgu tanimlandi ve tanisal ve patolojik incelemelere iliskin deneyimlerimiz literatur esliginde tartisildi. Ca­lis­ma­ pla­ni:­ Akciger epitelyal tumorunun eslik ettigi karsinoid tumorlu bes olgu (4 erkek, 1 kadin; ort. yas 61.8 yil; dagilim 50-72 yil) calismaya alindi. Oksuruk tum olgularda en belirgin semptom idi. Tum olgulara ameliyat sirasinda lenf nodu diseksiyonu veya lob spesifik lenf nodu diseksiyonu yapildi. Ortalama takip suresi 30 ay (dagilim 14-72 ay) idi. Bul gu lar: Tum olgulara anatomik rezeksiyon yapildi. Karsinoid tumorlu dort olguda, uc karsinom tesadufen bulundu; bunlarin biri bronkoskopi sirasinda tespit edildi. Besinci olguda adenokarsinom vardi ve karsinoid tumor bronkoskopi sirasinda tesadufen saptandi. Adenokarsinomlu olguda takip sirasinda ikinci bir karsinom bulundu. Karsinoid tumorlerin tumu 4 ila 12 mm arasinda degisen boyutlarda patolojik olarak tipik idi ve kucuk hucreli disi akciger kanseri evresi iki olguda T1aN0 ve uc olguda T2aN0 idi. Şu anda tum olgular sag olup, 14 ila 72 aylik (ortalama 30 ay) takipte semptomsuzdur. So­nuc:­Akcigerin karsinoid tumorleri dusuk dereceli maligniteler olup, es zamanli baska bir karsinoid tumor veya karsinom ile birliktelik gosterebilir. Her iki birliktelik de oldukca nadirdir ve kimi zaman ameliyati zorlastirabilir. Ameliyat oncesinde veya sonrasinda kapsamli bir bronkoskopik ve patolojik inceleme gogus cerrahisinde onemlidir.

[1]  P. Pagès,et al.  History of multiple previous malignancies should not be a contraindication to the surgical resection of lung cancer. , 2013, The Annals of thoracic surgery.

[2]  K. Shirouzu,et al.  A case of resected synchronous multiple primary lung cancer comprising adenocarcinoma and carcinoid (cancer-in-cancer) , 2012, General Thoracic and Cardiovascular Surgery.

[3]  A. Demir,et al.  Survival and prognostic factors in surgically resected synchronous multiple primary lung cancers. , 2011, European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery.

[4]  A. Hebisawa,et al.  Combined typical carcinoid and acinic cell tumor of the lung. , 2011, Interactive cardiovascular and thoracic surgery.

[5]  L. Kowalski,et al.  Second Primary Tumors in Patients with Head and Neck Cancer , 2011, Current oncology reports.

[6]  M. Conti,et al.  Results of Systematic Nodal Dissection in Typical and Atypical Carcinoid Tumors of the Lung , 2009, Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer.

[7]  L. Travis,et al.  The Epidemiology of Second Primary Cancers , 2006, Cancer Epidemiology Biomarkers & Prevention.

[8]  M. Stokkel,et al.  Second primary tumors involving non-small cell lung cancer: prevalence and its influence on survival. , 2005, Chest.

[9]  G. Pelosi,et al.  Synchronous bilateral lung carcinoid tumors: a rare entity? , 2003, European Journal of Cardio-Thoracic Surgery.

[10]  Yuh-Min Chen,et al.  Multiple primary malignancies involving lung cancer-clinical characteristics and prognosis. , 2002, Lung cancer.

[11]  J. Jett,et al.  Typical and atypical pulmonary carcinoids : outcome in patients presenting with regional lymph node involvement. , 2001, Chest.

[12]  E. Mark,et al.  Carcinogen exposure, p53 alteration, and K‐ras mutation in synchronous multiple primary lung carcinoma , 1999, Cancer.

[13]  Rosemurgy,et al.  Carcinoid Tumors of the Gut. , 1997, Cancer control : journal of the Moffitt Cancer Center.

[14]  K. Oberg.  Expression of growth factors and their receptors in neuroendocrine gut and pancreatic tumors, and prognostic factors for survival. , 1994, Annals of the New York Academy of Sciences.

[15]  J. Marshall,et al.  Carcinoid Tumors of the Gut: Our Experience Over Three Decades and Review of the Literature , 1993, Journal of clinical gastroenterology.

[16]  S. Saha,et al.  Carcinoid Tumors of the Gastrointestinal Tract: A 44‐Year Experience , 1989, Southern medical journal.

[17]  M. Mushinski,et al.  Tobacco and alcohol consumption in relation to the development of multiple primary cancers. , 1977, Cancer.

[18]  T. Berge,et al.  Carcinoid tumours. Frequency in a defined population during a 12-year period. , 2009, Acta pathologica et microbiologica Scandinavica. Section A, Pathology.