The second messenger phosphatidylinositol-5-phosphate facilitates antiviral innate immune signaling.
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[1] Zhijian J. Chen,et al. Cyclic GMP-AMP Synthase Is a Cytosolic DNA Sensor That Activates the Type I Interferon Pathway , 2013, Science.
[2] K. Ishii,et al. DNA damage sensor MRE11 recognizes cytosolic double-stranded DNA and induces type I interferon by regulating STING trafficking , 2013, Proceedings of the National Academy of Sciences.
[3] C. Reis e Sousa,et al. Signaling by myeloid C-type lectin receptors in immunity and homeostasis. , 2012, Annual review of immunology.
[4] D. Golenbock,et al. Beyond Empiricism: Informing Vaccine Development through Innate Immunity Research , 2012, Cell.
[5] Zhijian J. Chen,et al. STING Specifies IRF3 Phosphorylation by TBK1 in the Cytosolic DNA Signaling Pathway , 2012, Science Signaling.
[6] Richard A. Flavell,et al. Inflammasomes in health and disease , 2012, Nature.
[7] Stephan Ludwig,et al. Phosphatidylinositol‐3‐kinase (PI3K) is activated by influenza virus vRNA via the pathogen pattern receptor Rig‐I to promote efficient type I interferon production , 2011, Cellular microbiology.
[8] P. Cohen,et al. The TRAF-associated protein TANK facilitates cross-talk within the IκB kinase family during Toll-like receptor signaling , 2011, Proceedings of the National Academy of Sciences.
[9] Y. Kong,et al. Mapping a dynamic innate immunity protein interaction network regulating type I interferon production. , 2011, Immunity.
[10] C. Coban,et al. DNA released from dying host cells mediates aluminum adjuvant activity , 2011, Nature Medicine.
[11] S. Akira,et al. Toll-like receptors and their crosstalk with other innate receptors in infection and immunity. , 2011, Immunity.
[12] D. Rappolee,et al. The Phosphoinositide Kinase PIKfyve Is Vital in Early Embryonic Development , 2011, The Journal of Biological Chemistry.
[13] S. Akira,et al. The ubiquitin ligase TRIM56 regulates innate immune responses to intracellular double-stranded DNA. , 2010, Immunity.
[14] A. Iwasaki,et al. Bifurcation of Toll-Like Receptor 9 Signaling by Adaptor Protein 3 , 2010, Science.
[15] D. Vertommen,et al. Regulation of PIKfyve phosphorylation by insulin and osmotic stress. , 2010, Biochemical and biophysical research communications.
[16] David S. Goodsell,et al. AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibility , 2009, J. Comput. Chem..
[17] G. Randall,et al. Potential roles for cellular cofactors in hepatitis C virus replication complex formation , 2009, Communicative & integrative biology.
[18] A. Olson,et al. AutoDock Vina: Improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading , 2009, J. Comput. Chem..
[19] P. Cohen,et al. Use of the Pharmacological Inhibitor BX795 to Study the Regulation and Physiological Roles of TBK1 and IκB Kinase ϵ , 2009, Journal of Biological Chemistry.
[20] Hiroshi Kiyono,et al. Regulation of humoral and cellular gut immunity by lamina propria dendritic cells expressing Toll-like receptor 5 , 2008, Nature Immunology.
[21] K. Hinchliffe,et al. Regulation of extranuclear PtdIns5P production by phosphatidylinositol phosphate 4‐kinase 2α , 2008, FEBS letters.
[22] R. Coffman,et al. PI3K is critical for the nuclear translocation of IRF-7 and type I IFN production by human plasmacytoid predendritic cells in response to TLR activation , 2008, The Journal of experimental medicine.
[23] C. Coban,et al. TANK-binding kinase-1 delineates innate and adaptive immune responses to DNA vaccines , 2008, Nature.
[24] M. Waterfield,et al. A selective PIKfyve inhibitor blocks PtdIns(3,5)P2 production and disrupts endomembrane transport and retroviral budding , 2008, EMBO reports.
[25] F. Randow,et al. SINTBAD, a novel component of innate antiviral immunity, shares a TBK1‐binding domain with NAP1 and TANK , 2007, The EMBO journal.
[26] Jeremy G. Carlton,et al. The mammalian phosphatidylinositol 3-phosphate 5-kinase (PIKfyve) regulates endosome-to-TGN retrograde transport , 2006, Journal of Cell Science.
[27] S. Mohammed,et al. Nuclear PtdIns5P as a transducer of stress signaling: an in vivo role for PIP4Kbeta. , 2006, Molecular cell.
[28] K. Honda,et al. Type I Inteferon Gene Induction by the Interferon Regulatory Factor Family of Transcription Factors , 2006 .
[29] C. Coban,et al. Essential role of IPS-1 in innate immune responses against RNA viruses , 2006, The Journal of experimental medicine.
[30] L. Cantley,et al. PtdIns(5)P activates the host cell PI3‐kinase/Akt pathway during Shigella flexneri infection , 2006, The EMBO journal.
[31] Giulio Superti-Furga,et al. A physical and functional map of the human TNF-α/NF-κB signal transduction pathway , 2004, Nature Cell Biology.
[32] S. Akira,et al. X-ray crystal structure of IRF-3 and its functional implications , 2003, Nature Structural Biology.
[33] M. Karin,et al. Identification of NAP1, a Regulatory Subunit of IκB Kinase-Related Kinases That Potentiates NF-κB Signaling , 2003, Molecular and Cellular Biology.
[34] R. Derynck,et al. Crystal structure of IRF-3 reveals mechanism of autoinhibition and virus-induced phosphoactivation , 2003, Nature Structural Biology.
[35] T. Maniatis,et al. IKKε and TBK1 are essential components of the IRF3 signaling pathway , 2003, Nature Immunology.
[36] S. Koyasu. The role of PI3K in immune cells , 2003, Nature Immunology.
[37] A. Shisheva,et al. Phosphatidylinositol 5-Phosphate Biosynthesis Is Linked to PIKfyve and Is Involved in Osmotic Response Pathway in Mammalian Cells* , 2002, The Journal of Biological Chemistry.
[38] D. Creely,et al. IKK-i and TBK-1 are Enzymatically Distinct from the Homologous Enzyme IKK-2 , 2002, The Journal of Biological Chemistry.
[39] K. Hinchliffe,et al. Thrombin stimulation of platelets causes an increase in phosphatidylinositol 5‐phosphate revealed by mass assay , 2000, FEBS letters.
[40] D. Baltimore,et al. NF‐κB activation by a signaling complex containing TRAF2, TANK and TBK1, a novel IKK‐related kinase , 1999, The EMBO journal.
[41] J. Schacht,et al. Purification of polyphosphoinositides by chromatography on immobilized neomycin. , 1978, Journal of lipid research.
[42] C. Coban,et al. A Toll-like receptor–independent antiviral response induced by double-stranded B-form DNA , 2006, Nature Immunology.