to Transient Global Cerebral Ischemia Response Up-Regulated in Brain Microglia in Complement C1q Is Dramatically

Petry, Michael Loos and Eberhard WeihePatricia Salvati, Marcello Calabresi, Robert B. Sim, Franz Martin K.-H. Schafer, Wilhelm J. Schwaeble, Claes Post,http://www.jimmunol.org/content/164/10/5446J Immunol€2000; 164:5446-5452; ;Referenceshttp://www.jimmunol.org/content/164/10/5446.full#ref-list-1This article cites 42 articles, 9 of which you can access for free at: Subscriptionshttp://jimmunol.org/subscriptionsInformation about subscribing to The Journal of Immunology is online at: Permissionshttp://www.aai.org/ji/copyright.htmlSubmit copyright permission requests at: Email Alertshttp://jimmunol.org/cgi/alerts/etocReceive free email-alerts when new articles cite this article. Sign up at:

[1]  Yuan Zhang,et al.  Neuronal protection in stroke by an sLex-glycosylated complement inhibitory protein. , 1999, Science.

[2]  D. Dormont,et al.  Gene Expression in Scrapie , 1998, The Journal of Biological Chemistry.

[3]  P. Gasque,et al.  Complement expression in human brain. Biosynthesis of terminal pathway components and regulators in human glial cells and cell lines. , 1995, Journal of immunology.

[4]  G. Kreutzberg,et al.  Microglia, the first line of defence in brain pathologies. , 1995, Arzneimittel-Forschung.

[5]  T. Möller,et al.  Complement 5a controls motility of murine microglial cells in vitro via activation of an inhibitory G-protein and the rearrangement of the actin cytoskeleton , 1996, Neuroscience.

[6]  J. Brierley,et al.  A New Model of Bilateral Hemispheric Ischemia in the Unanesthetized Rat , 1979, Stroke.

[7]  M. Schäfer,et al.  Follicular dendritic cells, interdigitating cells, and cells of the monocyte-macrophage lineage are the C1q-producing sources in the spleen. Identification of specific cell types by in situ hybridization and immunohistochemical analysis. , 1995, Journal of immunology.

[8]  K. Ikeda,et al.  Complement gene expression in mouse microglia and astrocytes in culture: comparisons with mouse peritoneal macrophages , 1996, Neuroscience Letters.

[9]  T. Morgan,et al.  Kainic Acid and Decorticating Lesions Stimulate the Synthesis of C1q Protein in Adult Rat Brain , 1997, Journal of neurochemistry.

[10]  M. J. Walsh,et al.  Dual implication of 2',3'-cyclic nucleotide 3' phosphodiesterase as major autoantigen and C3 complement-binding protein in the pathogenesis of multiple sclerosis. , 1998, The Journal of clinical investigation.

[11]  P. Mattsson,et al.  Evidence for activation of the terminal pathway of complement and upregulation of sulfated glycoprotein (SGP)-2 in the hypoglossal nucleus following peripheral nerve injury. , 1995, Molecular and chemical neuropathology.

[12]  T. Schall,et al.  Neuronal expression of fractalkine in the presence and absence of inflammation , 1998, FEBS letters.

[13]  David A. Willoughby,et al.  Complement C1qB and C4 mRNAs responses to lesioning in rat brain , 1992, Experimental Neurology.

[14]  P. Gasque,et al.  Expression of complement in the brain: role in health and disease. , 1996, Immunology today.

[15]  J. Zimmer,et al.  Morphological and Immunophenotypic Microglial Changes in the Denervated Fascia Dentata of Adult Rats: Correlation with Blood–Brain Barrier Damage and Astroglial Reactions , 1997, Experimental Neurology.

[16]  P. Mcgeer,et al.  The inflammatory response system of brain: implications for therapy of Alzheimer and other neurodegenerative diseases , 1995, Brain Research Reviews.

[17]  C. Cotman,et al.  Cultured Rat Microglia Express C1q and Receptor for C1q: Implications for Amyloid Effects on Microglia , 1995, Experimental Neurology.

[18]  P. Mcgeer,et al.  Neurofibrillary tangles of Guam parkinson-dementia are associated with reactive microglia and complement proteins , 1996, Brain Research.

[19]  P. Verroust,et al.  Cryoglobulins, circulating immune complexes, and complement activation in cerebral malaria , 1981, Infection and immunity.

[20]  Steven A. Johnson,et al.  Perforant Path Transection Induces Complement C9 Deposition in Hippocampus , 1996, Experimental Neurology.

[21]  Brian J Cummings,et al.  Localization and Cell Association of C1q in Alzheimer's Disease Brain , 1996, Experimental Neurology.

[22]  D. Melton,et al.  Efficient in vitro synthesis of biologically active RNA and RNA hybridization probes from plasmids containing a bacteriophage SP6 promoter. , 1984, Nucleic acids research.

[23]  P. Gasque,et al.  The receptor for complement anaphylatoxin C3a is expressed by myeloid cells and nonmyeloid cells in inflamed human central nervous system: analysis in multiple sclerosis and bacterial meningitis. , 1998, Journal of immunology.

[24]  P. Riederer,et al.  Complement C1q and C3 mRNA expression in the frontal cortex of Alzheimer's patients , 1995, Journal of Molecular Medicine.

[25]  D. Walker,et al.  Neurons express proteins of the classical complement pathway in Alzheimer disease , 1997, Brain Research.

[26]  C. Post,et al.  Spinal prodynorphin gene expression in collagen-induced arthritis: Influence of the glucocorticosteroid budesonide , 1994, Neuroscience.

[27]  G R Stuart,et al.  Localisation of the C1q binding site within C 1 q receptor/calreticulin , 1996, FEBS letters.

[28]  David A. Willoughby,et al.  Selective expression of clusterin (SGP-2) and complement C1qB and C4 during responses to neurotoxinsin vivo andin vitro , 1994, Neuroscience.

[29]  J. Kimura,et al.  Regressive changes of astroglia in white matter lesions in cerebrovascular disease and Alzheimer’s disease patients , 1997, Acta Neuropathologica.

[30]  Steven A. Johnson,et al.  Expression of complement C1gB and C4 mRNAs during rat brain development , 1994 .

[31]  H. Koprowski,et al.  Expression of C1q, a subcomponent of the rat complement system, is dramatically enhanced in brains of rats with either Borna disease or experimental allergic encephalomyelitis , 1995, Journal of the Neurological Sciences.

[32]  C. Finch,et al.  Expression of complement C1qB and C4 mRNAs during rat brain development. , 1994, Brain research. Developmental brain research.

[33]  K. Frei,et al.  TNF-alpha-mediated expression of the receptor for anaphylatoxin C5a on neurons in experimental Listeria meningoencephalitis. , 1997, Journal of immunology.

[34]  T. Poulos,et al.  Aspartate residue 7 in amyloid β-protein is critical for classical complement pathway activation: Implications for Alzheimer's disease pathogenesis , 1997, Nature Medicine.

[35]  Pier Paolo Pandolfi,et al.  Homozygous C1q deficiency causes glomerulonephritis associated with multiple apoptotic bodies , 1998, Nature Genetics.

[36]  K. Hirayama,et al.  Increased concentration of C4d complement protein in the cerebrospinal fluids in progressive supranuclear palsy , 1994, Acta neurologica Scandinavica.

[37]  P. Mcgeer,et al.  Up-regulated production and activation of the complement system in Alzheimer's disease brain. , 1999, The American journal of pathology.

[38]  P. Gasque,et al.  Role of Complement in the Aetiology of Pick's Disease? , 1996, Journal of neuropathology and experimental neurology.

[39]  Rena Li,et al.  Neuronal expression of mRNAs for complement proteins of the classical pathway in Alzheimer brain , 1997, Brain Research.

[40]  A. Paetau,et al.  Complement activation in the central nervous system following blood–brain barrier damage in man , 1996, Annals of neurology.

[41]  H. Kimura,et al.  Early response of brain resident microglia to kainic acid-induced hippocampal lesions , 1994, Brain Research.

[42]  V. Perry,et al.  Characterization of the microglial response in murine scrapie , 1994, Neuropathology and applied neurobiology.

[43]  K. Whaley,et al.  Complement and Complement Deficiencies , 1997, Seminars in liver disease.