Haemodynamic response to exercise in patients with alcoholic liver cirrhosis.

Physical work capacity was evaluated by a multistage bicycle exercise test in 29 patients, 22 men and seven women aged 35-61 years (mean 49) with alcoholic liver cirrhosis and in a sex- and age-matched control group. The maximal work load was reduced in the patient group, mean 122 vs. 186 watts in men (P less than 0.001), and 60 vs. 119 watts in women (P less than 0.005). Resting heart rate was higher in patients (91 vs. 78 beats X min-1, P less than 0.005), and the maximal heart rate was lower (159 vs. 170 beats X min-1, P less than 0.001) compared with controls. Thirteen of 29 (45%) patients compared with 5 of 29 (17%) control subjects had an increase in left ventricular ejection fraction of less than or equal to 5% during exercise (P less than 0.05). The present results suggest that an impaired capacity of the cardiac function to respond adequately to physical stress may at times contribute to the reduced physical work capacity seen in patients with alcoholic liver cirrhosis.

[1]  E. Varnauskas,et al.  Coronary circulation during heavy exercise in control subjects and patients with coronary heart disease. , 2009, Acta medica Scandinavica.

[2]  O. Munck,et al.  Right and left ventricular ejection fraction and left ventricular volume changes at rest and during exercise in normal subjects. , 1984, European heart journal.

[3]  S. Ahmed,et al.  Cardiac function in alcoholics with cirrhosis: absence of overt cardiomyopathy--myth or fact? , 1984, Journal of the American College of Cardiology.

[4]  A. Morabito,et al.  Prognostic value of exercise EKG testing in asymptomatic normotensive subjects. A prospective matched study. , 1983, The New England journal of medicine.

[5]  M. Nieminen,et al.  Acute effects of alcohol, beta blockade, and their combination on left ventricular function and hemodynamics in normal man. , 1983, European heart journal.

[6]  J. Steinberg,et al.  Prevalence of clinically occult cardiomyopathy in chronic alcoholism. , 1981, American heart journal.

[7]  J. A. Snow,et al.  Echocardiographic abnormalities in chronic alcoholics with and without overt congestive heart failure. , 1981, The American journal of cardiology.

[8]  G. E. Newman,et al.  Cardiac Function at Rest and During Exercise in Normals and in Patients with Coronary Heart Disease: Evaluation by Radionuclide Angiocardiography , 1978, Annals of surgery.

[9]  G. Levi,et al.  Preclinical abnormaltiy of left ventricular function in chronic alcoholics. , 1977, British heart journal.

[10]  S. Ahmed,et al.  Preclinical cardiomyopathy in chronic alcoholics: a sex difference. , 1976, American heart journal.

[11]  R. Ross,et al.  Acute effects of low doses of alcohol on left ventricular function by echocardiography. , 1975, Circulation.

[12]  S. Ahmed,et al.  Depression of Myocardial Contractility with Low Doses of Ethanol in Normal Man , 1973, Circulation.

[13]  D. Spodick,et al.  Preclinical cardiac malfunction in chronic alcoholism. Comparison with matched normal controls and with alcoholic cardiomyopathy. , 1972, The New England journal of medicine.

[14]  J. Clausen,et al.  Physical Training in the Management of Coronary Artery Disease , 1969, Circulation.

[15]  M. Frank,et al.  Ventricular function in noncardiacs with alcoholic fatty liver: role of ethanol in the production of cardiomyopathy. , 1969, The Journal of clinical investigation.

[16]  C. S. Alexander.  Idiopathic heart disease. I. Analysis of 100 cases, with special reference to chronic alcoholism. , 1966, The American journal of medicine.

[17]  A. Askanas,et al.  The heart in chronic alcoholism: a noninvasive study. , 1980, American heart journal.