Complete Regression of Advanced Pancreatic Ductal Adenocarcinomas upon Combined Inhibition of EGFR and C-RAF.
暂无分享,去创建一个
R. Rabadán | M. Barbacid | M. Hidalgo | F. Al-Shahrour | F. Mulero | C. Guerra | Hossein Khiabanian | J. Perales-Patón | M. Drosten | C. Lechuga | Harrys K. C. Jacob | J. Iovanna | N. Dusetti | S. Ortega | O. Graña-Castro | C. Navas | L. Martin-Diaz | M. Musteanu | B. Sáinz | F. Sánchez‐Bueno | M. T. Blasco | Laura Esteban-Burgos | Jing Li | E. Castellano | L. Cabras | G. Martín-Serrano | Magdolna Djurec | Lucía Morales-Cacho | Emilie Bousquet-Mur | Osvaldo Graña-Castro | Guillermo Martín-Serrano
[1] R. Schmid,et al. New Horizons in KRAS-Mutant Lung Cancer: Dawn After Darkness , 2019, Front. Oncol..
[2] C. Guerra,et al. Pancreatic Ductal Deletion of Hnf1b Disrupts Exocrine Homeostasis, Leads to Pancreatitis, and Facilitates Tumorigenesis , 2019, Cellular and molecular gastroenterology and hepatology.
[3] H. Kocher,et al. Pancreatic Cancer , 2019, Methods in Molecular Biology.
[4] Nicholas D. Camarda,et al. Real-time Genomic Characterization of Advanced Pancreatic Cancer to Enable Precision Medicine. , 2018, Cancer discovery.
[5] Robert E Denroche,et al. Organoid Profiling Identifies Common Responders to Chemotherapy in Pancreatic Cancer. , 2018, Cancer discovery.
[6] M. Barbacid,et al. Genetically Engineered Mouse Models of K-Ras-Driven Lung and Pancreatic Tumors: Validation of Therapeutic Targets. , 2018, Cold Spring Harbor perspectives in medicine.
[7] P. Grippo,et al. Pancreatic cancer subtypes: a roadmap for precision medicine , 2018, Annals of medicine.
[8] M. Barbacid,et al. c-RAF Ablation Induces Regression of Advanced Kras/Trp53 Mutant Lung Adenocarcinomas by a Mechanism Independent of MAPK Signaling. , 2018, Cancer cell.
[9] Mathias J Friedrich,et al. Evolutionary routes and KRAS dosage define pancreatic cancer phenotypes , 2018, Nature.
[10] D. Pisano,et al. Nextpresso: Next Generation Sequencing Expression Analysis Pipeline , 2017, Current Bioinformatics.
[11] M. Karin,et al. Stress-Activated NRF2-MDM2 Cascade Controls Neoplastic Progression in Pancreas. , 2017, Cancer cell.
[12] F. Gnad,et al. Kras mutant genetically engineered mouse models of human cancers are genomically heterogeneous , 2017, Proceedings of the National Academy of Sciences.
[13] J. Iovanna,et al. Pancreatic Adenocarcinoma Therapeutic Targets Revealed by Tumor-Stroma Cross-Talk Analyses in Patient-Derived Xenografts , 2017, Cell reports.
[14] Steven J. M. Jones,et al. Integrated Genomic Characterization of Pancreatic Ductal Adenocarcinoma. , 2017, Cancer cell.
[15] M. Barbacid,et al. A Braf kinase-inactive mutant induces lung adenocarcinoma , 2017, Nature.
[16] Raghu Kalluri,et al. Exosomes Facilitate Therapeutic Targeting of Oncogenic Kras in Pancreatic Cancer , 2017, Nature.
[17] N. McGranahan,et al. Clonal Heterogeneity and Tumor Evolution: Past, Present, and the Future , 2017, Cell.
[18] Bo Wang,et al. Failure of Investigational Drugs in Late-Stage Clinical Development and Publication of Trial Results. , 2016, JAMA internal medicine.
[19] Brandon Da Silva,et al. NRF2 Promotes Tumor Maintenance by Modulating mRNA Translation in Pancreatic Cancer , 2016, Cell.
[20] R. Gibbs,et al. Genomic analyses identify molecular subtypes of pancreatic cancer , 2016, Nature.
[21] J. Mesirov,et al. The Molecular Signatures Database Hallmark Gene Set Collection , 2015 .
[22] S. Robertson,et al. Expanding the power of recombinase-based labeling to uncover cellular diversity , 2015, Development.
[23] Jen Jen Yeh,et al. Virtual microdissection identifies distinct tumor- and stroma-specific subtypes of pancreatic ductal adenocarcinoma , 2015, Nature Genetics.
[24] M. Hidalgo,et al. Pancreatic cancer: from state-of-the-art treatments to promising novel therapies , 2015, Nature Reviews Clinical Oncology.
[25] Michael A. Choti,et al. Whole-exome sequencing of pancreatic cancer defines genetic diversity and therapeutic targets , 2015, Nature Communications.
[26] M. Burotto,et al. Gefitinib and erlotinib in metastatic non-small cell lung cancer: a meta-analysis of toxicity and efficacy of randomized clinical trials. , 2015, The oncologist.
[27] J. Kench,et al. Whole genomes redefine the mutational landscape of pancreatic cancer , 2015, Nature.
[28] W. Huber,et al. Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2 , 2014, Genome Biology.
[29] Benjamin D. Smith,et al. Projecting cancer incidence and deaths to 2030: the unexpected burden of thyroid, liver, and pancreas cancers in the United States. , 2014, Cancer research.
[30] J. Ahn,et al. Comparison of Clinical Outcomes Following Gefitinib and Erlotinib Treatment in Non–Small-Cell Lung Cancer Patients Harboring an Epidermal Growth Factor Receptor Mutation in Either Exon 19 or 21 , 2014, Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer.
[31] David Goldstein,et al. Increased survival in pancreatic cancer with nab-paclitaxel plus gemcitabine. , 2013, The New England journal of medicine.
[32] Raul Rabadan,et al. SAVI: a statistical algorithm for variant frequency identification , 2013, BMC Systems Biology.
[33] W. Placek,et al. Acneiform rash during lung cancer therapy with erlotinib (Tarceva®) , 2013, Postepy dermatologii i alergologii.
[34] Justin Guinney,et al. GSVA: gene set variation analysis for microarray and RNA-Seq data , 2013, BMC Bioinformatics.
[35] Lincoln D. Stein,et al. Pancreatic cancer genomes reveal aberrations in axon guidance pathway genes , 2012, Nature.
[36] M. Barbacid,et al. EGF receptor signaling is essential for k-ras oncogene-driven pancreatic ductal adenocarcinoma. , 2012, Cancer cell.
[37] Jens T Siveke,et al. EGF receptor is required for KRAS-induced pancreatic tumorigenesis. , 2012, Cancer cell.
[38] K. Horiuchi,et al. Epidermal ADAM17 maintains the skin barrier by regulating EGFR ligand–dependent terminal keratinocyte differentiation , 2012, The Journal of experimental medicine.
[39] M. Barbacid,et al. What we have learned about pancreatic cancer from mouse models. , 2012, Gastroenterology.
[40] Gerald C. Chu,et al. Oncogenic Kras Maintains Pancreatic Tumors through Regulation of Anabolic Glucose Metabolism , 2012, Cell.
[41] David R. Kelley,et al. Differential gene and transcript expression analysis of RNA-seq experiments with TopHat and Cufflinks , 2012, Nature Protocols.
[42] C. Galbán,et al. Oncogenic Kras is required for both the initiation and maintenance of pancreatic cancer in mice. , 2012, The Journal of clinical investigation.
[43] E. Moding,et al. Generation of primary tumors with Flp recombinase in FRT-flanked p53 mice , 2011, Disease Models & Mechanisms.
[44] M. Barbacid,et al. Pancreatitis-induced inflammation contributes to pancreatic cancer by inhibiting oncogene-induced senescence. , 2011, Cancer cell.
[45] M. Barbacid,et al. c-Raf, but not B-Raf, is essential for development of K-Ras oncogene-driven non-small cell lung carcinoma. , 2011, Cancer cell.
[46] P. Spellman,et al. Subtypes of Pancreatic Ductal Adenocarcinoma and Their Differing Responses to Therapy , 2011, Nature Medicine.
[47] S. Pease,et al. Advanced protocols for animal transgenesis : an ISTT manual , 2011 .
[48] M. Barbacid,et al. A synthetic lethal interaction between K-Ras oncogenes and Cdk4 unveils a therapeutic strategy for non-small cell lung carcinoma. , 2010, Cancer cell.
[49] David A Gewirtz,et al. Toxicity issues in cancer drug development. , 2010, Current opinion in investigational drugs.
[50] Richard Durbin,et al. Fast and accurate long-read alignment with Burrows–Wheeler transform , 2010, Bioinform..
[51] M. Hidalgo. Pancreatic cancer. , 2010, The New England journal of medicine.
[52] Gonçalo R. Abecasis,et al. The Sequence Alignment/Map format and SAMtools , 2009, Bioinform..
[53] Richard Durbin,et al. Sequence analysis Fast and accurate short read alignment with Burrows – Wheeler transform , 2009 .
[54] Cole Trapnell,et al. Ultrafast and memory-efficient alignment of short DNA sequences to the human genome , 2009, Genome Biology.
[55] G. Parmigiani,et al. Core Signaling Pathways in Human Pancreatic Cancers Revealed by Global Genomic Analyses , 2008, Science.
[56] M. Sibilia,et al. The EGF receptor is required for efficient liver regeneration , 2007, Proceedings of the National Academy of Sciences.
[57] A. Bhandoola,et al. Deletion of the developmentally essential gene ATR in adult mice leads to age-related phenotypes and stem cell loss. , 2007, Cell stem cell.
[58] P. Murawa,et al. Erlotinib Plus Gemcitabine Compared With Gemcitabine Alone in Patients With Advanced Pancreatic Cancer: A Phase III Trial of the National Cancer Institute of Canada Clinical Trials Group , 2023, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[59] M. Barbacid,et al. Chronic pancreatitis is essential for induction of pancreatic ductal adenocarcinoma by K-Ras oncogenes in adult mice. , 2007, Cancer cell.
[60] Pablo Tamayo,et al. Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles , 2005, Proceedings of the National Academy of Sciences of the United States of America.
[61] R. Hruban,et al. Trp53R172H and KrasG12D cooperate to promote chromosomal instability and widely metastatic pancreatic ductal adenocarcinoma in mice. , 2005, Cancer cell.
[62] Manuel Serrano,et al. Tumor induction by an endogenous K-ras oncogene is highly dependent on cellular context. , 2003, Cancer cell.
[63] P. Chambon,et al. A directional strategy for monitoring Cre-mediated recombination at the cellular level in the mouse , 2003, Nature Biotechnology.
[64] A. Berns,et al. Synergistic tumor suppressor activity of BRCA2 and p53 in a conditional mouse model for breast cancer , 2001, Nature Genetics.
[65] E. Wagner,et al. Protective Role of Raf-1 in Salmonella-Induced Macrophage Apoptosis , 2001, The Journal of experimental medicine.
[66] D. V. Von Hoff,et al. Improvements in survival and clinical benefit with gemcitabine as first-line therapy for patients with advanced pancreas cancer: a randomized trial. , 1997, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.