Intake of coffee, caffeine and other methylxanthines and risk of Type I vs Type II endometrial cancer

Background:Coffee and other sources of methylxanthines and risk of Type I vs Type II endometrial cancer (EC) have not been evaluated previously.Methods:Prospective cohort of 23 356 postmenopausal women with 471 Type I and 71 Type II EC cases.Results:Type I EC was statistically significantly associated with caffeinated (relative risk (RR)=0.65 for 4+ cups per day vs ⩽1 cup per month: 95% confidence interval (CI): 0.47–0.89) but not decaffeinated (RR=0.76; 95% CI: 0.50–1.15) coffee intake; there were no associations with tea, cola or chocolate, or for Type II EC. The inverse association with caffeinated coffee intake was specific to women with a body mass index 30+ kg m−2 (RR=0.56; 95% CI: 0.36–0.89).Conclusion:Coffee may protect against Type I EC in obese postmenopausal women.

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