Molecular conformation and biological activity of central nervous system active drugs

[1]  A H BECKETT,et al.  SYNTHETIC ANALGESICS: STEREOCHEMICAL CONSIDERATIONS , 1954, The Journal of pharmacy and pharmacology.

[2]  C. Pfeiffer Optical isomerism and pharmacological action, a generalization. , 1956, Science.

[3]  L. Bernardi,et al.  Ergoline derivatives—VIII , 1965 .

[4]  C. Hansch,et al.  The parabolic dependence of drug action upon lipophilic character as revealed by a study of hypnotics. , 1968, Journal of medicinal chemistry.

[5]  R. Bergin,et al.  The structure of the catecholamines. II. The crystal structure of dopamine hydrochloride. , 1968, Acta crystallographica. Section B: Structural crystallography and crystal chemistry.

[6]  P. Andrews Molecular orbital calculations on anticonvulsant drugs. , 1969, Journal of medicinal chemistry.

[7]  B. Craven,et al.  The crystal structures of two polymorphs of 5-ethyl-5-isoamylbarbituric acid (amobarbital). , 1969, Acta crystallographica. Section B: Structural crystallography and crystal chemistry.

[8]  B. Craven,et al.  The crystal structure of 5‐ethyl‐5‐(1‐methylbutenyl)‐barbituric acid , 1969 .

[9]  C. Chothia,et al.  On the conformations of hallucinogenic molecules and their correlation. , 1969, Proceedings of the National Academy of Sciences of the United States of America.

[10]  R. Karler,et al.  A study of the excitatory effects of barbiturates. , 1970, The Journal of pharmacology and experimental therapeutics.

[11]  M. Wilhelm,et al.  Versuch einer stereochemisch-strukturellen Klassifizierung der Trizyklus-Psychopharmaka mit Einschluß der Dibenzo-bicyclooctadiene , 1970 .

[12]  A. Camerman,et al.  Diphenylhydantoin and Diazepam: Molecular Structure Similarities and Steric Basis of Anticonvulsant Activity , 1970, Science.

[13]  T. Bustard,et al.  The conformation of dopamine hydrochloride , 1971 .

[14]  A. Camerman,et al.  The stereochemical basis of anticonvulsant drug action. I. The crystal and molecular structure of diphenylhydantoin, a noncentrosymmetric structure solved by centric symbolic addition , 1971 .

[15]  A. Camerman,et al.  The stereochemical basis of anticonvulsant drug action. 3. The structure of procyclidine hydrochloride. , 1971, Molecular pharmacology.

[16]  R. Deslauriers,et al.  Conformational studies of amphetamine and medicinally important derivatives by nuclear magnetic resonance spectroscopy. , 1971, Journal of medicinal chemistry.

[17]  P. Andrews,et al.  Association of CNS active drugs with 9-ethyladenine. , 1971, Biochemical pharmacology.

[18]  R. Bergin,et al.  The crystal and molecular structure of amphetamine sulphate , 1971 .

[19]  S. Snyder,et al.  Chlorpromazine and dopamine: conformational similarities that correlate with the antischizophrenic activity of phenothiazine drugs. , 1971, Proceedings of the National Academy of Sciences of the United States of America.

[20]  K. Bailey,et al.  Proton Magnetic Resonance Spectra of Some Amphetamines and Related Compounds and Observations on Rotamer Populations , 1971 .

[21]  K. Bailey Analysis of NMR spectra for rotamer populations of dimethoxyamphetamines. , 1971, Journal of pharmaceutical sciences.

[22]  A. Camerman,et al.  Stereochemical basis of anticonvulsant drug action. II. Molecular structure of diazepam. , 1972, Journal of the American Chemical Society.

[23]  A. Camerman,et al.  The stereochemical basis of anticonvulsant drug action. IV. The crystal and molecular structure of trihexyphenidyl. , 1972, Journal of the American Chemical Society.

[24]  J P Gervois,et al.  Quantum mechanical study of the conformational properties of phenethylamines of biochemical and medicinal interest. , 1972, Journal of Medicinal Chemistry.

[25]  A. Grey,et al.  A Conformational Study of Lysergic Acid and iso-Lysergic Acid Dialkylamides by Proton Magnetic Resonance Spectroscopy , 1972 .

[26]  P Brawley,et al.  The pharmacology of hallucinogens. , 1972, Pharmacological reviews.

[27]  B. Pullman,et al.  A molecular orbital study of the conformation of barbiturates. , 1972, Journal of theoretical biology.

[28]  P. Williams Polymorphism of phenobarbitone: the crystal structure of 5-ethyl-5-phenylbarbituric acid monohydrate , 1973 .

[29]  Theoretical studies on the conformations of psilocin and mescaline. , 1973, Molecular pharmacology.

[30]  C. Chothia,et al.  Molecular structures of hallucinogenic substances: lysergic acid diethylamide, psilocybin, and 2,4,5-trimethoxyamphetamine. , 1973, Molecular pharmacology.

[31]  R. J. Abraham,et al.  The nuclear magnetic resonance spectra and conformations of cyclic compounds. Part X. Conformational equilibria in 5-substituted 10,11-dihydrodibenz[b,f]azepines , 1974 .

[32]  O. Kennard,et al.  Possible pharmacological and theoretical implications of X-ray structure of the tricyclic antidepressant imipramine , 1974, Nature.

[33]  L. Sternbach,et al.  Quinazolines and 1,4-benzodiazepines. 64. Comparison of the stereochemistry of diazepam with that of close analogs with marginal biological activity. , 1974, Journal of Medicinal Chemistry.

[34]  R. Ferris,et al.  The phenyl rings of tricyclic antidepressants and related compounds as determinants of the potency of inhibition of the amine pumps in adrenergic neurons of the rabbit aorta and in rat cortical synaptosomes. , 1974, The Journal of pharmacology and experimental therapeutics.

[35]  F. Bloom,et al.  The biochemical basis of neuropharmacology, 2nd ed. , 1974 .

[36]  P. H. Smit,et al.  The crystal and molecular structure of 5-ethyl-5-(l,3-dimethylbutyl)barbituric acid (α-methylamobarbital) , 1974 .

[37]  Olga Kennard,et al.  Crystal and molecular structure of the psychotropic drug 2-(4-ethyl-2,5-dimethoxyphenyl)-1-methylethylamine (4-ethyl-2,5-dimethoxyamphetamine) , 1974 .

[38]  A. Camerman,et al.  The Stereochemical Basis of Anticonvulsant Drug Action. V. The Crystal and Molecular Structure of Sulthiame , 1975 .

[39]  O. Kennard,et al.  A crystallographic and theoretical study of the conformation of DOET and its significance for the hallucinogenic amphetamines , 1975, The Journal of pharmacy and pharmacology.

[40]  G H Loew,et al.  Quantum chemical studies of morphine-like opiate narcotics. Effect of N-substituent variations. , 1975, Journal of medicinal chemistry.

[41]  G. W. Schnuelle,et al.  Conformation energies and electronic structure of phenethylamine and amphetamine. , 1975, Journal of theoretical biology.

[42]  L. Tuomisto,et al.  Conformationally rigid amphetamine analogs as inhibitors of monoamine uptake by brain synaptosomes. , 1976, Journal of medicinal chemistry.

[43]  R. R. Bresee,et al.  Enthalpies of hydrogen bonding in psychotropic drugs. , 1976, Journal of pharmaceutical sciences.

[44]  P. Portoghese,et al.  Stereochemical studies on medicinal agents. 20. Absolute configuration and analgetic potency alpha-promedol enantiomers. The role of the C-4 chiral center in conferring stereoselectivity in axial- and equatorial-phenyl prodine congeners. , 1976, Journal of medicinal chemistry.

[45]  R. W. Beaver,et al.  Interaction of barbiturates with neurologic effects of high pressure , 1976 .

[46]  S H Snyder,et al.  The opiate receptor: a model explaining structure-activity relationships of opiate agonists and antagonists. , 1976, Proceedings of the National Academy of Sciences of the United States of America.

[47]  M. Sacerdoti,et al.  7‐Nitro‐1,3‐dihydro‐5‐phenyl‐2H‐1,4‐benzodiazepin‐2‐one (nitrazepam) , 1977 .

[48]  G R Marshall,et al.  Proposal for the biologically active conformation of opiates and enkephalin. , 1977, Proceedings of the National Academy of Sciences of the United States of America.

[49]  H. Höltje Molekular Orbital Berechnungen zur Struktur des Barbituratrezeptors , 1977 .

[50]  J. Rodgers,et al.  The enkephalins and opiates: structure‐activity relations , 1977, The Journal of pharmacy and pharmacology.

[51]  A. Camerman,et al.  Ethylphenacemide and phenacemide: conformational similarities to diphenylhydantoin and stereochemical basis of anticonvulsant activity. , 1977, Proceedings of the National Academy of Sciences of the United States of America.

[52]  H. Rollema,et al.  Conformational analysis of dopamine by the INDO molecular orbital method , 1977, The Journal of pharmacy and pharmacology.

[53]  D. R. Curtis,et al.  A new class of GABA agonist , 1977, Nature.

[54]  K. Voith,et al.  Neuroleptics related to butaclamol. An investigation of the effects of chlorine substituents on the aromatic rings. , 1978, Journal of medicinal chemistry.

[55]  M. Sacerdoti,et al.  The crystal and molecular structure of 7‐chloro‐1,3‐dihydro‐3‐hydroxy‐5‐phenyl‐2H‐1,4‐benzodiazepin‐2‐one (oxazepam) , 1978 .

[56]  D. Miller,et al.  Conformation of dopamine at the dopamine receptor. , 1978, Proceedings of the National Academy of Sciences of the United States of America.

[57]  L. E. Sutton,et al.  Pharmaceutically active small molecules , 1978 .

[58]  A. Camerman,et al.  STEREOCHEMICAL BASIS OF ANTICONVULSANT DRUG ACTION. VI. CRYSTAL AND MOLECULAR R STRUCTURE OF DIPHENYLSILANEDIOL , 1978 .

[59]  D. E. Nichols,et al.  LSD and phenethylamine hallucinogens: new structural analogy and implications for receptor geometry. , 1978, Life sciences.

[60]  O. Kennard,et al.  Common stereochemical features in anti‐epileptic drugs: a reinvestigation , 1978, The Journal of pharmacy and pharmacology.

[61]  T. de Paulis,et al.  On the topology of the norepinephrine transport carrier in rat hypothalamus. The site of action of tricyclic uptake inhibitors. , 1978, Molecular pharmacology.

[62]  B. Soltz,et al.  Pulsed nuclear magnetic resonance study of molecular motion in solid imipramine hydrochloride, desipramine hydrochloride, and iminobibenzyl , 1978 .

[63]  E. Way Endogenous and exogenous opiate agonists and antagonists: Proceedings of the International Narcotic Research Club conference, June 11-15, 1979 North Falmouth, Massachusetts, USA , 1979 .

[64]  P. Andrews,et al.  Convulsant, anticonvulsant and anaesthetic barbiturates. 5-Ethyl-5-(3'-methyl-but-2'-enyl)-barbituric acid and related compounds. , 1979, European journal of pharmacology.

[65]  C J Niemegeers,et al.  A systematic study of the pharmacological activities of dopamine antagonists. , 1979, Life sciences.

[66]  J. Kebabian,et al.  Multiple receptors for dopamine , 1979, Nature.

[67]  L. Eiden,et al.  Inhibition of neuronal uptake of 3H-biogenic amines into rat cerebral cortex by partially and fully saturated derivatives of imipramine and desipramine. The importance of the aromatic ring in adrenergic amines--part 3. , 1979, Biochemical pharmacology.

[68]  P. Andrews,et al.  GABA agonists and antagonists. , 1979, Biochemical pharmacology.

[69]  Ralph E. Christoffersen,et al.  Computer-assisted drug design , 1979 .

[70]  M. Vigorita,et al.  Nuclear magnetic resonance of 1,4-benzodiazepines. II Stereochemistry of 1,3-dihydro-2H-1,4-benzodiazepin-2-ones by lanthanide shift reagents†‡ , 1979 .

[71]  P. Andrews,et al.  Conformational analysis of muscimol, a GABA agonist. , 1979, Journal of theoretical biology.

[72]  B. Metcalf Inhibitors of GABA metabolism. , 1979, Biochemical Pharmacology.

[73]  Joyce J. Kaufman,et al.  New Optimal Strategies for Ab-Initio Quantum Chemical Calculations on Large Drugs, Carcinogens, Teratogens, and Biomolecules , 1979 .

[74]  A. Camerman,et al.  Stereochemical characteristics of dopamine agonists: molecular structure of bromocriptine and structural comparisons with apomorphine. , 1979, Molecular pharmacology.

[75]  H. Yamamura,et al.  Conformationally restricted tricyclic antidepressants. 1. Octahydrodibenzazepinonaphthyridines as rigid imipramine analogues. , 1980, Journal of medicinal chemistry.

[76]  P. Andrews,et al.  Convulsant and anticonvulsant barbiturates. 1. Molecular conformations from classical potential-energy calculations. , 1980, Journal of medicinal chemistry.

[77]  P. Seeman Brain dopamine receptors. , 1980, Pharmacological reviews.

[78]  J. Rodgers,et al.  2‐Amino‐6,7‐dihydroxytetrahydronaphthalene and the receptor‐site preferred conformation of dopamine—a commentary , 1980, The Journal of pharmacy and pharmacology.

[79]  P. Krogsgaard‐Larsen,et al.  Pharmacological studies of interactions between benzodiazepines and GABA receptors , 1980, Brain Research Bulletin.

[80]  J. Clemens,et al.  Bicyclic and tricyclic ergoline partial structures. Rigid 3-(2-aminoethyl)pyrroles and 3- and 4-(2-aminoethyl)pyrazoles as dopamine agonists. , 1980, Journal of medicinal chemistry.

[81]  P. Krogsgaard‐Larsen,et al.  Chapter 5. GABA Agonists and Antagonists , 1980 .

[82]  D. E. Nichols,et al.  Conformational energy differences between side chain alkylated analogues of the hallucinogen 1-(2,5-dimethoxy-4-methylphenyl)-2-aminopropane. , 1980, Journal of medicinal chemistry.

[83]  H. Moereels,et al.  Structural Aspects of the Structure–Activity Relationships of Neuroleptics: Principles and Methods , 1980 .

[84]  A. Hallett,et al.  Pronounced pharmacological differences arising from minor structural changes in conformationally defined amphetamine analogues. Comparative evaluation of endo- and exo-2-amino- and endo- and exo-2-(methylamino)benzobicyclo[2.2.1]heptene and -benzobicylco[2.2.2]octene analogues. Conformationally defi , 1980, Journal of medicinal chemistry.

[85]  P. Skolnick,et al.  The mechanism(s) of action of the benzodiazepines , 1981, Medicinal research reviews.

[86]  H. Möhler,et al.  Autoradiographic localization of benzodiazepine receptors in immunocytochemically identified gamma-aminobutyrergic synapses. , 1981, Proceedings of the National Academy of Sciences of the United States of America.

[87]  P. Andrews,et al.  Conformations of barbiturates related to pentobarbitone. I. Crystal structure oftrans-5-ethyl-5-but-1′-enyl barbituric acid , 1981 .

[88]  P. Plotsky,et al.  Dopamine levels in hypophysial stalk plasma and prolactin levels in peripheral plasma of the lactating rat: effects of a simulated suckling stimulus. , 1981, Neuroendocrinology.

[89]  A B Davidson,et al.  A dopamine receptor model and its application in the design of a new class of rigid pyrrolo[2,3-g]isoquinoline antipsychotics. , 1981, Journal of medicinal chemistry.

[90]  M. Ticku Interaction of depressant, convulsant, and anticonvulsant barbiturates with the [3H]diazepam binding site of the benzodiazepine-GABA-receptor-ionophore complex. , 1981, Biochemical pharmacology.

[91]  F. LaBella Is there a general anesthesia receptor. , 1981, Canadian journal of physiology and pharmacology.