A role of Wnt/β-catenin signals in hepatic fate specification of human umbilical cord blood-derived mesenchymal stem cells

Human umbilical cord blood-derived mesenchymal stem cells (UCBMSCs) are expected to be an excellent source of cells for transplantation. In addition, the stem cell plasticity of human UCBMSCs, whic...

[1]  A. Zorn,et al.  Repression of Wnt/β-catenin signaling in the anterior endoderm is essential for liver and pancreas development , 2007, Development.

[2]  B. Drénou,et al.  Transdifferentiation of hepatocyte‐like cells from the human hepatoma HepaRG cell line through bipotent progenitor , 2007, Hepatology.

[3]  B. Cieply,et al.  beta-Catenin is critical for early postnatal liver growth. , 2007, American journal of physiology. Gastrointestinal and liver physiology.

[4]  T. Kondo.  Epigenetic alchemy for cell fate conversion. , 2006, Current opinion in genetics & development.

[5]  D. Stainier,et al.  Mesodermal Wnt2b signalling positively regulates liver specification , 2006, Nature.

[6]  A. Balmain.  Oncogenes and cell proliferation: Shifting paradigms in the understanding and treatment of cancer , 2006 .

[7]  K. Cadigan,et al.  Wnt signaling: complexity at the surface , 2006, Journal of Cell Science.

[8]  Xiao‐Kang Li,et al.  Characterization and gene transfer in mesenchymal stem cells derived from human umbilical-cord blood. , 2005, The Journal of laboratory and clinical medicine.

[9]  C. Verfaillie,et al.  Stem cell plasticity , 2005, Hematology.

[10]  T. Kiyono,et al.  Immortalization of human fetal cells: the life span of umbilical cord blood-derived cells can be prolonged without manipulating p16INK4a/RB braking pathway. , 2005, Molecular biology of the cell.

[11]  L. Sommer,et al.  Wnt signaling and the regulation of stem cell function. , 2004, Current opinion in cell biology.

[12]  O. Lee,et al.  In vitro hepatic differentiation of human mesenchymal stem cells , 2004, Hepatology.

[13]  I. Hisatome,et al.  Analyses to clarify rich fractions in hepatic progenitor cells from human umbilical cord blood and cell fusion. , 2004, Biochemical and biophysical research communications.

[14]  P. Quesenberry,et al.  Chromatin remodeling and stem cell theory of relativity , 2004, Journal of cellular physiology.

[15]  K. Zaret,et al.  Liver development update: new embryo models, cell lineage control, and morphogenesis. , 2004, Current opinion in genetics & development.

[16]  N. Fausto.  Liver regeneration and repair: Hepatocytes, progenitor cells, and stem cells , 2004, Hepatology.

[17]  G. Michalopoulos,et al.  Beta-catenin is temporally regulated during normal liver development. , 2004, Gastroenterology.

[18]  W. Fu,et al.  The presence of FGF2 signaling determines whether beta-catenin exerts effects on proliferation or neuronal differentiation of neural stem cells. , 2004, Developmental biology.

[19]  O. Lee,et al.  Isolation of multipotent mesenchymal stem cells from umbilical cord blood. , 2004, Blood.

[20]  C. Chuong,et al.  Morphogenesis of chicken liver: identification of localized growth zones and the role of beta-catenin/Wnt in size regulation. , 2004, Developmental biology.

[21]  Klaus Pfeffer,et al.  Fusion of bone-marrow-derived cells with Purkinje neurons, cardiomyocytes and hepatocytes , 2003, Nature.

[22]  Jason M. Tennessen,et al.  The mouse secreted frizzled-related protein 5 gene is expressed in the anterior visceral endoderm and foregut endoderm during early post-implantation development. , 2003, Gene expression patterns : GEP.

[23]  I. Weissman,et al.  A role for Wnt signalling in self-renewal of haematopoietic stem cells , 2003, Nature.

[24]  Karen E. Pilcher,et al.  Expression of the Wnt inhibitor, sFRP5, in the gut endoderm of Xenopus. , 2002, Gene expression patterns : GEP.

[25]  R. Schwartz,et al.  Multipotent adult progenitor cells from bone marrow differentiate into functional hepatocyte-like cells. , 2002, The Journal of clinical investigation.

[26]  A. Ruifrok,et al.  Hepatocytes and epithelial cells of donor origin in recipients of peripheral-blood stem cells. , 2002, The New England journal of medicine.

[27]  H. Kondoh,et al.  Wnt signaling plays an essential role in neuronal specification of the dorsal spinal cord. , 2002, Genes & development.

[28]  H. Yost,et al.  Protein phosphatase 2A and its B56 regulatory subunit inhibit Wnt signaling in Xenopus , 2001, The EMBO journal.

[29]  P. Argani,et al.  Wnt Signaling in Human Development: Beta-Catenin Nuclear Translocation in Fetal Lung, Kidney, Placenta, Capillaries, Adrenal, and Cartilage , 2001, Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society.

[30]  W. Birchmeier,et al.  β-Catenin Controls Hair Follicle Morphogenesis and Stem Cell Differentiation in the Skin , 2001, Cell.

[31]  Neil D. Theise,et al.  Multi-Organ, Multi-Lineage Engraftment by a Single Bone Marrow-Derived Stem Cell , 2001, Cell.

[32]  S. Sokol,et al.  A Positive Role for the PP2A Catalytic Subunit in Wnt Signal Transduction* , 2000, The Journal of Biological Chemistry.

[33]  Xin Wang,et al.  Purified hematopoietic stem cells can differentiate into hepatocytes in vivo , 2000, Nature Medicine.

[34]  R. Poulsom,et al.  Cell differentiation: Hepatocytes from non-hepatic adult stem cells , 2000, Nature.

[35]  Rebekah Gardner,et al.  Liver from bone marrow in humans , 2000, Hepatology.

[36]  Sunil Badve,et al.  Derivation of hepatocytes from bone marrow cells in mice after radiation‐induced myeloablation , 2000, Hepatology.

[37]  H. Clevers,et al.  Synergy between tumor suppressor APC and the beta-catenin-Tcf4 target Tcf1. , 1999, Science.

[38]  P. Schiller,et al.  Age‐Related Osteogenic Potential of Mesenchymal Stromal Stem Cells from Human Vertebral Bone Marrow , 1999, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[39]  K. Zaret,et al.  Initiation of mammalian liver development from endoderm by fibroblast growth factors. , 1999, Science.

[40]  S. Ogawa,et al.  Cardiomyocytes can be generated from marrow stromal cells in vitro. , 1999, The Journal of clinical investigation.

[41]  P. Lansdorp,et al.  Biology of Human Umbilical Cord Blood‐Derived Hematopoietic Stem/Progenitor Cells , 1998, Stem cells.

[42]  M. Sharpe,et al.  Scatter factor/hepatocyte growth factor is essential for liver development , 1995, Nature.

[43]  H. Kawasaki,et al.  Serum hepatocyte growth factor levels in liver diseases: Clinical implications , 1995, Hepatology.

[44]  Catherine M. Verfaillie,et al.  Pluripotency of mesenchymal stem cells derived from adult marrow , 2007, Nature.

[45]  G. Michalopoulos,et al.  Wnt impacts growth and differentiation in ex vivo liver development. , 2004, Experimental cell research.

[46]  N. Chao,et al.  Umbilical cord blood transplantation in adults using myeloablative and nonmyeloablative preparative regimens. , 2004, Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation.

[47]  P. Greengard,et al.  Maintenance of pluripotency in human and mouse embryonic stem cells through activation of Wnt signaling by a pharmacological GSK-3-specific inhibitor , 2004, Nature Medicine.

[48]  Tetsu Akiyama,et al.  Summary The Wnt / β-catenin pathway directs neuronal differentiation of cortical neural precursor cells , 2004 .

[49]  多胡 賢一,et al.  Inhibition of Wnt signaling by ICAT, a Novel β-catenin-interacting protein , 2000 .