Neuroprotective effect of bicyclol in rat ischemic stroke: Down-regulates TLR4, TLR9, TRAF6, NF-κB, MMP-9 and up-regulates claudin-5 expression
暂无分享,去创建一个
Jian Zhang | Linyu Chen | Xiangjian Zhang | Chunhua Zhu | L. Cui | Xiangjian Zhang | Chunhua Zhu | Lina Wang | Lili Cui | Baosheng Fu | Lan Zhang | Xumeng Zhao | Xue Bai | Lan-tong Zhang | Linyu Chen | Xumeng Zhao | Xue Bai | Jian Zhang | B. Fu | Li-na Wang | Li-li Cui
[1] Y. Li,et al. Protective effect of bicyclol on liver injury induced by hepatic warm ischemia/reperfusion in rats , 2009, Hepatology research : the official journal of the Japan Society of Hepatology.
[2] R. Vink,et al. Suppression of inflammation in ischemic and hemorrhagic stroke: therapeutic options , 2009, Current opinion in neurology.
[3] H. Lehrach,et al. TLR2 has a detrimental role in mouse transient focal cerebral ischemia. , 2007, Biochemical and biophysical research communications.
[4] Y. Liu,et al. Oxymatrine Downregulates TLR4, TLR2, MyD88, and NF-κB and Protects Rat Brains against Focal Ischemia , 2010, Mediators of inflammation.
[5] G. Rosenberg,et al. Metalloproteinase inhibition blocks edema in intracerebral hemorrhage in the rat , 1997, Neurology.
[6] Wei Du,et al. Tanshinone II A down-regulates HMGB1, RAGE, TLR4, NF-κB expression, ameliorates BBB permeability and endothelial cell function, and protects rat brains against focal ischemia , 2010, Brain Research.
[7] Q. Xia,et al. Bicyclol attenuates oxidative stress and neuronal damage following transient forebrain ischemia in mouse cortex and hippocampus , 2009, Neuroscience Letters.
[8] E. Lo,et al. Extracellular proteolysis in brain injury and inflammation: Role for plasminogen activators and matrix metalloproteinases , 2002, Journal of neuroscience research.
[9] G. Rosenberg,et al. Matrix metalloproteinases and TIMPs are associated with blood-brain barrier opening after reperfusion in rat brain. , 1998, Stroke.
[10] Bo Zhang,et al. Protective effect of bicyclol on lipopolysaccharide-induced acute lung injury in mice. , 2011, Pulmonary pharmacology & therapeutics.
[11] Hartwig Wolburg,et al. Tight junctions of the blood-brain barrier: development, composition and regulation. , 2002, Vascular pharmacology.
[12] Yan Li,et al. Mechanism of protective action of bicyclol against CCl4‐induced liver injury in mice , 2005, Liver international : official journal of the International Association for the Study of the Liver.
[13] M. Schwab,et al. Nogo-A Expression After Focal Ischemic Stroke in the Adult Rat , 2008, Stroke.
[14] G. Rosenberg,et al. MMP-mediated disruption of claudin-5 in the blood-brain barrier of rat brain after cerebral ischemia. , 2011, Methods in molecular biology.
[15] Y. Liu,et al. Oxymatrine protects rat brains against permanent focal ischemia and downregulates NF-κB expression , 2009, Brain Research.
[16] T. Senga,et al. Secretion of matrix metalloproteinase‐9 by the proinflammatory cytokine, IL‐1β: a role for the dual signalling pathways, Akt and Erk , 2003, Genes to cells : devoted to molecular & cellular mechanisms.
[17] P. Deyn,et al. The complexity of neurobiological processes in acute ischemic stroke , 2009, Clinical Neurology and Neurosurgery.
[18] K. Tracey,et al. The nuclear factor HMGB1 mediates hepatic injury after murine liver ischemia-reperfusion , 2005, The Journal of experimental medicine.
[19] M. Fini,et al. Role for Matrix Metalloproteinase 9 after Focal Cerebral Ischemia: Effects of Gene Knockout and Enzyme Inhibition with BB-94 , 2000, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.
[20] P. Cao,et al. Sequential Autophosphorylation Steps in the Interleukin-1 Receptor-associated Kinase-1 Regulate its Availability as an Adapter in Interleukin-1 Signaling* , 2004, Journal of Biological Chemistry.
[21] Chun-Hua Wang,et al. Effect of Baicalin on Matrix Metalloproteinase-9 Expression and Blood–Brain Barrier Permeability Following Focal Cerebral Ischemia in Rats , 2011, Neurochemical Research.
[22] Jing Zhao,et al. Effects of bicyclol on immunological liver fibrosis in rats , 2010, Journal of Asian natural products research.
[23] P. Weinstein,et al. Reversible middle cerebral artery occlusion without craniectomy in rats. , 1989, Stroke.
[24] F. Barone,et al. Matrix metalloproteinase expression increases after cerebral focal ischemia in rats: inhibition of matrix metalloproteinase-9 reduces infarct size. , 1998, Stroke.
[25] Shizuo Akira,et al. Signaling to NF-kappaB by Toll-like receptors. , 2007, Trends in molecular medicine.
[26] M. Karjalainen‐Lindsberg,et al. Nuclear Factor- (cid:1) B Contributes to Infarction After Permanent Focal Ischemia , 2004 .
[27] Shizuo Akira,et al. Signaling to NF-?B by Toll-like receptors , 2007 .
[28] Wei Du,et al. Neuroprotection of early and short-time applying atorvastatin in the acute phase of cerebral ischemia: Down-regulated 12/15-LOX, p38MAPK and cPLA2 expression, ameliorated BBB permeability , 2010, Brain Research.
[29] G. Plitas,et al. Toll‐like receptor 9 inhibition confers protection from liver ischemia–reperfusion injury , 2010, Hepatology.
[30] M. Fini,et al. Effects of Matrix Metalloproteinase-9 Gene Knock-Out on the Proteolysis of Blood–Brain Barrier and White Matter Components after Cerebral Ischemia , 2001, The Journal of Neuroscience.
[31] S. Tsukita,et al. Size-selective loosening of the blood-brain barrier in claudin-5–deficient mice , 2003, The Journal of cell biology.
[32] Jie Cui,et al. Reduced cerebral ischemia-reperfusion injury in Toll-like receptor 4 deficient mice. , 2007, Biochemical and biophysical research communications.
[33] Ana M. Blanco,et al. Ethanol-induced iNOS and COX-2 expression in cultured astrocytes via NF-&kgr;B , 2004, Neuroreport.
[34] Yaqing Zhang,et al. Cytidine-phosphate-guanosine oligonucleotides induce interleukin-8 production through activation of TLR9, MyD88, NF-κB, and ERK pathways in odontoblast cells. , 2012, Journal of endodontics.
[35] M. Fujimura,et al. Early Appearance of Activated Matrix Metalloproteinase-9 after Focal Cerebral Ischemia in Mice: A Possible Role in Blood—Brain Barrier Dysfunction , 1999, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.
[36] Y. Liu,et al. Curcumin upregulates transcription factor Nrf2, HO-1 expression and protects rat brains against focal ischemia , 2009, Brain Research.
[37] Qing Wang,et al. The inflammatory response in stroke , 2007, Journal of Neuroimmunology.
[38] Shizuo Akira,et al. Toll-like receptor signalling , 2004, Nature Reviews Immunology.
[39] Huiping Wang,et al. Protective effect of bicyclol on acute hepatic failure induced by lipopolysaccharide and D-galactosamine in mice. , 2006, European journal of pharmacology.
[40] Z. Zeng,et al. Lipopolysaccharide (LPS) regulates TLR4 signal transduction in nasopharynx epithelial cell line 5-8F via NFkappaB and MAPKs signaling pathways. , 2007, Molecular immunology.
[41] G. Rosenberg,et al. Closure of the Blood-Brain Barrier by Matrix Metalloproteinase Inhibition Reduces rtPA-Mediated Mortality in Cerebral Ischemia With Delayed Reperfusion , 2003, Stroke.
[42] R. Simon,et al. Toll-Like Receptor 9: A New Target of Ischemic Preconditioning in the Brain , 2008, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.
[43] R. Nitsch,et al. Toll-like receptor 2 mediates CNS injury in focal cerebral ischemia , 2007, Journal of Neuroimmunology.
[44] D. Lee,et al. Neuroprotective effects of Schisandrin B against transient focal cerebral ischemia in Sprague-Dawley rats. , 2012, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
[45] Eng H. Lo,et al. The Science of Stroke: Mechanisms in Search of Treatments , 2010, Neuron.
[46] M. Mattson,et al. Pivotal role for neuronal Toll-like receptors in ischemic brain injury and functional deficits , 2007, Proceedings of the National Academy of Sciences.
[47] W. Dietrich,et al. Inflammatory Mechanisms after Ischemia and Stroke , 2003, Journal of neuropathology and experimental neurology.
[48] Linyu Chen,et al. Neuroprotective effect of early and short-time applying sophoridine in pMCAO rat brain: Down-regulated TRAF6 and up-regulated p-ERK1/2 expression, ameliorated brain infaction and edema , 2012, Brain Research Bulletin.