The NLRP3 Inflammasome in Alzheimer’s Disease

[1]  M. Guillot-Sestier,et al.  Innate immunity in Alzheimer's disease: a complex affair. , 2013, CNS & neurological disorders drug targets.

[2]  Ying-Dong Zhang,et al.  Antimalarial Drug Artemisinin Extenuates Amyloidogenesis and Neuroinflammation in APPswe/PS1dE9 Transgenic Mice via Inhibition of Nuclear Factor‐κB and NLRP3 Inflammasome Activation , 2013, CNS neuroscience & therapeutics.

[3]  M. Heneka,et al.  NLRP3 is activated in Alzheimer´s disease and contributes to pathology in APP/PS1 mice , 2012, Nature.

[4]  Vishva M Dixit,et al.  Inflammasomes and their roles in health and disease. , 2012, Annual review of cell and developmental biology.

[5]  B. Ryffel,et al.  ATP release and purinergic signaling: a common pathway for particle-mediated inflammasome activation , 2012, Cell Death and Disease.

[6]  Jiujiu Yu,et al.  Critical role for calcium mobilization in activation of the NLRP3 inflammasome , 2012, Proceedings of the National Academy of Sciences.

[7]  T. Ikezu,et al.  The Classification of Microglial Activation Phenotypes on Neurodegeneration and Regeneration in Alzheimer’s Disease Brain , 2012, Archivum Immunologiae et Therapiae Experimentalis.

[8]  Deming Zhao,et al.  The NALP3 inflammasome is involved in neurotoxic prion peptide-induced microglial activation , 2012, Journal of Neuroinflammation.

[9]  D. Golenbock,et al.  Activation of the NLRP 3 Inflammasome , 2012 .

[10]  F. LaFerla,et al.  Blocking IL-1 Signaling Rescues Cognition, Attenuates Tau Pathology, and Restores Neuronal β-Catenin Pathway Function in an Alzheimer’s Disease Model , 2011, The Journal of Immunology.

[11]  Jinfeng Liu,et al.  Non-canonical inflammasome activation targets caspase-11 , 2011, Nature.

[12]  R. Ransohoff,et al.  Heterogeneity of CNS myeloid cells and their roles in neurodegeneration , 2011, Nature Neuroscience.

[13]  M. Lamkanfi,et al.  Deregulated inflammasome signaling in disease , 2011, Immunological reviews.

[14]  V. Dixit,et al.  Modulation of Inflammasome Pathways by Bacterial and Viral Pathogens , 2011, The Journal of Immunology.

[15]  Anna K Rieger,et al.  Cutting Edge: Reactive Oxygen Species Inhibitors Block Priming, but Not Activation, of the NLRP3 Inflammasome , 2011, The Journal of Immunology.

[16]  S. Ryter,et al.  Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome. , 2011, Nature immunology.

[17]  M. Lamkanfi.  Emerging inflammasome effector mechanisms , 2011, Nature Reviews Immunology.

[18]  Pedro Romero,et al.  Type I interferon inhibits interleukin-1 production and inflammasome activation. , 2011, Immunity.

[19]  J. Tschopp,et al.  A role for mitochondria in NLRP3 inflammasome activation , 2011, Nature.

[20]  M. di Luca,et al.  Distribution of interleukin-1 receptor complex at the synaptic membrane driven by interleukin-1β and NMDA stimulation , 2011, Journal of Neuroinflammation.

[21]  Christine E. Becker,et al.  Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes , 2010, Nature Immunology.

[22]  V. Dixit,et al.  Manipulation of host cell death pathways during microbial infections. , 2010, Cell host & microbe.

[23]  M. Huang,et al.  Inflammasome inhibition as a pathogenic stealth mechanism. , 2010, Cell host & microbe.

[24]  I. Mitroulis,et al.  Targeting IL-1beta in disease; the expanding role of NLRP3 inflammasome. , 2010, European journal of internal medicine.

[25]  Fred H. Gage,et al.  Mechanisms Underlying Inflammation in Neurodegeneration , 2010, Cell.

[26]  S. Akira,et al.  Pattern Recognition Receptors and Inflammation , 2010, Cell.

[27]  J. Tschopp,et al.  NLRP3 inflammasome activation: the convergence of multiple signalling pathways on ROS production? , 2010, Nature Reviews Immunology.

[28]  R. Maccioni,et al.  Neuroimmunomodulation in the Pathogenesis of Alzheimer’s Disease , 2010, Neuroimmunomodulation.

[29]  J. Tschopp,et al.  The Inflammasomes , 2010, Cell.

[30]  V. Dixit,et al.  The Inflammasomes , 2009, PLoS pathogens.

[31]  V. Dixit,et al.  Glyburide inhibits the Cryopyrin/Nalp3 inflammasome , 2009, The Journal of cell biology.

[32]  G. Pascal,et al.  Evolution and functional divergence of NLRP genes in mammalian reproductive systems , 2009, BMC Evolutionary Biology.

[33]  E. Alnemri,et al.  Cutting Edge: NF-κB Activating Pattern Recognition and Cytokine Receptors License NLRP3 Inflammasome Activation by Regulating NLRP3 Expression1 , 2009, The Journal of Immunology.

[34]  J. Tschopp,et al.  T cells dampen innate immune responses through inhibition of NLRP1 and NLRP3 inflammasomes , 2009, Nature.

[35]  W. Nickel,et al.  Mechanisms of regulated unconventional protein secretion , 2009, Nature Reviews Molecular Cell Biology.

[36]  Catherine Rabouille,et al.  Mechanisms of regulated unconventional protein secretion , 2009, Nature Reviews Molecular Cell Biology.

[37]  Heikki Tanila,et al.  Expression of interleukin-18 is increased in the brains of Alzheimer's disease patients , 2009, Neurobiology of Aging.

[38]  R. Kuljiš,et al.  The Role of Neuroimmunomodulation in Alzheimer's Disease , 2009, Annals of the New York Academy of Sciences.

[39]  V. Dixit,et al.  Inflammasomes: guardians of cytosolic sanctity , 2009, Immunological reviews.

[40]  S. Hickman,et al.  Microglial Dysfunction and Defective β-Amyloid Clearance Pathways in Aging Alzheimer's Disease Mice , 2008, The Journal of Neuroscience.

[41]  K. Rock,et al.  Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization , 2008, Nature Immunology.

[42]  K. Moore,et al.  The NALP3 inflammasome is involved in the innate immune response to amyloid-β , 2008, Nature Immunology.

[43]  Rebecca C Taylor,et al.  Apoptosis: controlled demolition at the cellular level , 2008, Nature Reviews Molecular Cell Biology.

[44]  D. Holtzman,et al.  Rapid appearance and local toxicity of amyloid-β plaques in a mouse model of Alzheimer’s disease , 2008, Nature.

[45]  C. Stehlik,et al.  COPs and POPs: Modulators of Inflammasome Activity1 , 2007, The Journal of Immunology.

[46]  Gabriel Núñez,et al.  Intracellular NOD-like receptors in host defense and disease. , 2007, Immunity.

[47]  G. Núñez,et al.  Caspase‐1 inflammasomes in infection and inflammation , 2007, Journal of leukocyte biology.

[48]  M. O’Banion,et al.  Sustained hippocampal IL-1 beta overexpression mediates chronic neuroinflammation and ameliorates Alzheimer plaque pathology. , 2007, The Journal of clinical investigation.

[49]  W. Behan,et al.  Interleukin‐1β but not tumor necrosis factor‐α potentiates neuronal damage by quinolinic acid: Protection by an adenosine A2A receptor antagonist , 2007 .

[50]  H. Forman,et al.  ATP Activates a Reactive Oxygen Species-dependent Oxidative Stress Response and Secretion of Proinflammatory Cytokines in Macrophages* , 2007, Journal of Biological Chemistry.

[51]  W. Behan,et al.  Interleukin-1beta but not tumor necrosis factor-alpha potentiates neuronal damage by quinolinic acid: protection by an adenosine A2A receptor antagonist. , 2007, Journal of neuroscience research.

[52]  M. Pickering,et al.  Pro-inflammatory cytokines and their effects in the dentate gyrus. , 2007, Progress in brain research.

[53]  F. Martinon,et al.  Gout-associated uric acid crystals activate the NALP3 inflammasome , 2006, Nature.

[54]  S. Barger,et al.  Journal of Neuroinflammation Interleukin-1 Mediates Alzheimer and Lewy Body Pathologies , 2022 .

[55]  U. Gómez-Pinedo,et al.  Proinflammatory cytokines and apoptosis following glutamate-induced excitotoxicity mediated by p38 MAPK in the hippocampus of neonatal rats , 2005, Journal of Neuroimmunology.

[56]  K. Krause,et al.  Chemokine receptors in the central nervous system: role in brain inflammation and neurodegenerative diseases , 2005, Brain Research Reviews.

[57]  M. Wiranowska,et al.  Role and Mechanisms of Interleukin-1 in the Modulation of Neurotoxicity , 2003, Neuroimmunomodulation.

[58]  J. Hardy,et al.  The Amyloid Hypothesis of Alzheimer ’ s Disease : Progress and Problems on the Road to Therapeutics , 2009 .

[59]  H. Hampel,et al.  Inflammatory repertoire of Alzheimer's disease and nondemented elderly microglia in vitro , 2001, Glia.

[60]  R. Schliebs,et al.  β-Amyloid-induced glial expression of both pro- and anti-inflammatory cytokines in cerebral cortex of aged transgenic Tg2576 mice with Alzheimer plaque pathology , 2001, Brain Research.

[61]  S. Kassis,et al.  Inhibition of p38 mitogen‐activated protein kinase provides neuroprotection in cerebral focal ischemia , 2001, Medicinal research reviews.

[62]  N. Bazan,et al.  Interleukin‐1 beta activates expression of cyclooxygenase‐2 and inducible nitric oxide synthase in primary hippocampal neuronal culture: Platelet‐activating factor as a preferential mediator of cyclooxygenase‐2 expression , 1999, Journal of neuroscience research.

[63]  M. Lynch,et al.  Evidence That Increased Hippocampal Expression of the Cytokine Interleukin-1β Is a Common Trigger for Age- and Stress-Induced Impairments in Long-Term Potentiation , 1998, The Journal of Neuroscience.

[64]  M. Lynch,et al.  Increased Hippocampal Expression of the Cytokine Interleukin-1 b Is a Common Trigger for Age-and Stress-Induced Impairments in Long-Term Potentiation , 1998 .