The Possibilities of Scintigraphic Visualization of Surfactants in the Lung of the Rat

Incorporation of radioactive iodine into the surfactant system of the rat lung has been studied. Specially prepared particles labelled by 125I-oleic acid or 131I-oleic acid were injected intravenously and the distribution of radioiodine in the body of the animals was observed at various time intervals by means of a gamma camera and a gamma counter. The results showing appreciable accumulation of isotope in the lungs and the surfactant phospholipids, constitute a basis for the development of a new scintigraphic method for studying metabolic functions and morphology of the lung.

[1]  A. Jobe,et al.  Labeling of phospholipids in the surfactant and subcellular fractions of rabbit lung. , 1978, The Journal of biological chemistry.

[2]  Š. Spaventi,et al.  The Use of 81mKr Gas for the Measurement of Absolute Regional Lung Ventilation , 1977, Nuklearmedizin.

[3]  A. Naimark.  Cellular dynamics and lipid metabolism in the lung. , 1973, Federation proceedings.

[4]  T. Chakera,et al.  Pulmonary fibrosis following therapy with Melphalan for multiple myeloma , 1972, Journal of clinical pathology.

[5]  R. Kirschner,et al.  Pulmonary lesions associated with busulfan therapy of chronic myelogenous leukemia , 1971, Cancer.

[6]  H. Kaplan,et al.  LUNG PHOTOSCANS WITH MACROAGGREGATES OF HUMAN SERUM RADIOALBUMIN. EXPERIMENTAL BASIS AND INITIAL CLINICAL TRIALS. , 1964, Health physics.

[7]  H. Wagner,et al.  DIAGNOSIS OF MASSIVE PULMONARY EMBOLISM IN MAN BY RADIOISOTOPE SCANNING. , 1964, The New England journal of medicine.

[8]  P. Curtis.  Hyaline membrane disease. , 1957, The Journal of pediatrics.

[9]  N. Gross.  Early physiologic and biochemical effects of thoracic X-irradiation on the pulmonary surfactant system. , 1978, Journal of Laboratory and Clinical Medicine.

[10]  R. J. King.  The surfactant system of the lung. , 1974, Federation proceedings.

[11]  W. Barry,et al.  Retention, distribution and absorption of inhaled albumin aerosol and absorbed dose estimates from its I131 and TC99m labels. , 1967, The American journal of roentgenology, radium therapy, and nuclear medicine.

[12]  J. Felts.  BIOCHEMISTRY OF THE LUNG. , 1964, Health physics.