Effect of insulin on glucose- and arginine-stimulated somatostatin secretion from the isolated perfused rat pancreas.

The effects of exogenous insulin on somatostatin secretion from the isolated perfused rat pancreas have been investigated in the presence of 5.6 mM glucose and when somatostatin secretion was stimulated by either glucose (16.7 mM) or arginine (20 mM). Insulin (15 mU/ml) significantly and rapidly suppressed glucose- and arginine-stimulated somatostatin release. However, at 5.6 mM glucose and, in the absence of other stimulators of somatostatin release, insulin had no effect on the somatostatin secretion rate.

[1]  C. Wollheim,et al.  Glucose and Cyclic AMP as Stimulators of Somatostatin and Insulin Secretion From the Isolated, Perfused Rat Pancreas: A Quantitative Study , 1981, Diabetes.

[2]  Y. Seino,et al.  Effects of Insulin and Pancreatic Polypeptide on Gastric Somatostatin Release , 1980, Diabetes.

[3]  R. Unger,et al.  Gastric and Pancreatic Release of Somatostatin-like Immunoreactivity During the Gastric Phase of a Meal: Effects of Truncal Vagotomy and Atropine in the Anesthetized Dog , 1979, Diabetes.

[4]  G. Weir,et al.  Insulin stimulates somatostatin and inhibits glucagon secretion from the perfused chicken pancreas-duodenum. , 1979, Life sciences.

[5]  L. Orci,et al.  Somatostatin secretion from monolayer cultures of neonatal rat pancreas. , 1979, Endocrinology.

[6]  J. Gerich,et al.  Increased somatostatin release from pancreases of alloxan diabetic rats perfused in vitro. , 1979, Life sciences.

[7]  門脇 誠三.  Somatostatin release from isolated perfused rat pancreas : possible role of endogenous somatostatin on insulin release , 1979 .

[8]  L Orci,et al.  Insulin, glucagon, and somatostatin secretion in the regulation of metabolism. , 1978, Annual review of physiology.

[9]  C. Wollheim,et al.  Somatostatin- and epinephrine-induced modifications of 45Ca++ fluxes and insulin release in rat pancreatic islets maintained in tissue culture. , 1977, The Journal of clinical investigation.

[10]  R. Unger,et al.  Immunoreactive somatostatin levels in plasma of normal and alloxan diabetic dogs , 1977, FEBS letters.

[11]  C. Wollheim,et al.  Somatostatin inhibition of pancreatic glucagon release from monolayer cultures and interactions with calcium. , 1977, Endocrinology.

[12]  L. Orci,et al.  Pancreatic immunoreactive somatostatin release. , 1977, Proceedings of the National Academy of Sciences of the United States of America.

[13]  E. Samols,et al.  Intraislet negative insulin-glucagon feedback. , 1976, Metabolism: clinical and experimental.

[14]  E. Samols,et al.  Remarkable potency of somatostatin as a glucagon suppressant. , 1976, Metabolism: clinical and experimental.

[15]  P. Raskin,et al.  Effect of insulin-glucose infusions on plasma glucagon levels in fasting diabetics and nondiabetics. , 1975, The Journal of clinical investigation.

[16]  P. Lacy,et al.  Somatostatin inhibition of insulin release from freshly isolated and organ cultured rat islets of Langerhans in vitro. , 1975, Biochemical and biophysical research communications.

[17]  G. Grodsky,et al.  Inhibition by somatostatin of glucagon and insulin release from the perfused rat pancreas in response to arginine, isoproterenol and theophylline: evidence for a preferential effect on glucagon secretion. , 1975, Endocrinology.

[18]  Choh Hao Li,et al.  Direct inhibition of insulin secretion by synthetic somatostatin. , 1974, Biochemical and biophysical research communications.

[19]  C. J. Goodner,et al.  Somatostatin: Hypothalamic Inhibitor of the Endocrine Pancreas , 1974, Science.

[20]  W. A. Müller,et al.  The effect of experimental insulin deficiency on glucagon secretion. , 1971, The Journal of clinical investigation.

[21]  F. Wolff,et al.  A Rat Pancreas-Small Gut Preparation for the Study of Intestinal Factor(s) and Insulin Release , 1969, Diabetes.

[22]  T. B. Schwartz,et al.  Beta-cytotrophic effects of glucose, glucagon, and tolbutamide in man. , 1967, Lancet.

[23]  G. Grodsky,et al.  Effect of pulse administration of glucose or glucagon on insulin secretion in vitro. , 1967, Metabolism: clinical and experimental.

[24]  V. Marks,et al.  PROMOTION OF INSULIN SECRETION BY GLUCAGON. , 1965, Lancet.