Development of a Human APOE Knock-in Mouse Model for Study of Cognitive Function After Cancer Chemotherapy

[1]  J. VanMeter,et al.  Cancer-Related Cognitive Outcomes Among Older Breast Cancer Survivors in the Thinking and Living With Cancer Study. , 2018, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[2]  G. Winocur,et al.  Chemotherapy and cognition: International cognition and cancer task force recommendations for harmonising preclinical research. , 2018, Cancer treatment reviews.

[3]  D. Butterfield,et al.  Doxorubicin-induced elevated oxidative stress and neurochemical alterations in brain and cognitive decline: protection by MESNA and insights into mechanisms of chemotherapy-induced cognitive impairment (“chemobrain”) , 2018, Oncotarget.

[4]  C. Albanese,et al.  Divergent brain changes in two audiogenic rat strains: A voxel-based morphometry and diffusion tensor imaging comparison of the genetically epilepsy prone rat (GEPR-3) and the Wistar Audiogenic Rat (WAR) , 2018, Neurobiology of Disease.

[5]  Andrew Saykin,et al.  Exploring the nexus of Alzheimer's disease and related dementias with cancer and cancer therapies: A convening of the Alzheimer's Association & Alzheimer's Drug Discovery Foundation , 2017, Alzheimer's & Dementia.

[6]  Xiaochuan Sun,et al.  Bexarotene protects against traumatic brain injury in mice partially through apolipoprotein E , 2017, Neuroscience.

[7]  G. Rebeck,et al.  Alzheimer's Disease Genetic Risk Factor APOE-ε4 Also Affects Normal Brain Function. , 2016, Current Alzheimer research.

[8]  A. Jemal,et al.  Cancer treatment and survivorship statistics, 2016 , 2016, CA: a cancer journal for clinicians.

[9]  Julia H. Rowland,et al.  Anticipating the “Silver Tsunami”: Prevalence Trajectories and Comorbidity Burden among Older Cancer Survivors in the United States , 2016, Cancer Epidemiology, Biomarkers & Prevention.

[10]  S. Dumanis,et al.  Identification and modification of amyloid-independent phenotypes of APOE4 mice , 2016, Experimental Neurology.

[11]  A. Smit,et al.  Neurobiological changes by cytotoxic agents in mice , 2016, Behavioural Brain Research.

[12]  S. Kesler,et al.  Neurotoxic Effects of Anthracycline- vs Nonanthracycline-Based Chemotherapy on Cognition in Breast Cancer Survivors. , 2016, JAMA oncology.

[13]  A. Saykin,et al.  Imaging Brain Networks After Cancer and Chemotherapy: Advances Toward Etiology and Unanswered Questions. , 2016, JAMA oncology.

[14]  Manasi Malik,et al.  Genetics ignite focus on microglial inflammation in Alzheimer’s disease , 2015, Molecular Neurodegeneration.

[15]  T. Ahles,et al.  Doxorubicin and cyclophosphamide induce cognitive dysfunction and activate the ERK and AKT signaling pathways , 2015, Behavioural Brain Research.

[16]  Burkhard Becher,et al.  Immune attack: the role of inflammation in Alzheimer disease , 2015, Nature Reviews Neuroscience.

[17]  Pinal N. Kanabar,et al.  APOE‐modulated Aβ‐induced neuroinflammation in Alzheimer's disease: current landscape, novel data, and future perspective , 2015, Journal of neurochemistry.

[18]  C. Limoli,et al.  Stem cell transplantation reverses chemotherapy-induced cognitive dysfunction. , 2015, Cancer research.

[19]  Jason H. Moore,et al.  Longitudinal assessment of cognitive changes associated with adjuvant treatment for breast cancer: the impact of APOE and smoking , 2014, Psycho-oncology.

[20]  A. Smit,et al.  Sheltering Behavior and Locomotor Activity in 11 Genetically Diverse Common Inbred Mouse Strains Using Home-Cage Monitoring , 2014, PloS one.

[21]  J. Rowland,et al.  Cancer survivorship issues: life after treatment and implications for an aging population. , 2014, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[22]  Jeanne S Mandelblatt,et al.  Cognitive effects of cancer systemic therapy: implications for the care of older patients and survivors. , 2014, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[23]  G. Rebeck,et al.  Aging reduces glial uptake and promotes extracellular accumulation of Aβ from a lentiviral vector , 2014, Front. Aging Neurosci..

[24]  M. LaDu,et al.  Human APOE4 increases microglia reactivity at Aβ plaques in a mouse model of Aβ deposition , 2014, Journal of Neuroinflammation.

[25]  A. Saykin,et al.  Cognitive impairment in older patients with breast cancer before systemic therapy: is there an interaction between cancer and comorbidity? , 2014, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[26]  L. Carey,et al.  Effect of cytotoxic chemotherapy on markers of molecular age in patients with breast cancer. , 2014, Journal of the National Cancer Institute.

[27]  F. Joly,et al.  Chemotherapy-induced long-term alteration of executive functions and hippocampal cell proliferation: Role of glucose as adjuvant , 2014, Neuropharmacology.

[28]  C. Rosenfeld,et al.  Barnes maze testing strategies with small and large rodent models. , 2014, Journal of visualized experiments : JoVE.

[29]  J. VanMeter,et al.  Cognitive effects of cancer and its treatments at the intersection of aging: what do we know; what do we need to know? , 2013, Seminars in oncology.

[30]  A. Saykin,et al.  Neuroimaging biomarkers and cognitive function in non-CNS cancer and its treatment: Current status and recommendations for future research , 2013, Brain Imaging and Behavior.

[31]  Hagen B. Huttner,et al.  Dynamics of Hippocampal Neurogenesis in Adult Humans , 2013, Cell.

[32]  E. Weeber,et al.  Young APOE4 targeted replacement mice exhibit poor spatial learning and memory, with reduced dendritic spine density in the medial entorhinal cortex. , 2013, Learning & memory.

[33]  Huaxi Xu,et al.  Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy , 2013, Nature Reviews Neurology.

[34]  R. Hancock,et al.  The Liver X Receptor Agonist GW3965 Improves Recovery from Mild Repetitive Traumatic Brain Injury in Mice Partly through Apolipoprotein E , 2013, PloS one.

[35]  S. Dumanis,et al.  APOE genotype affects the pre‐synaptic compartment of glutamatergic nerve terminals , 2013, Journal of neurochemistry.

[36]  S. Dumanis,et al.  APOE genotype alters glial activation and loss of synaptic markers in mice , 2012, Glia.

[37]  C. Limoli,et al.  Impaired Cognitive Function and Hippocampal Neurogenesis following Cancer Chemotherapy , 2012, Clinical Cancer Research.

[38]  H. Arrighi,et al.  Prevalence of Apolipoprotein E4 Genotype and Homozygotes (APOE e4/4) among Patients Diagnosed with Alzheimer’s Disease: A Systematic Review and Meta-Analysis , 2011, Neuroepidemiology.

[39]  M. Dodd,et al.  A prospective longitudinal study of chemotherapy-induced cognitive changes in breast cancer patients , 2011, Supportive Care in Cancer.

[40]  Jitbanjong Tangpong,et al.  Doxorubicin-induced central nervous system toxicity and protection by xanthone derivative of Garcinia Mangostana , 2011, Neuroscience.

[41]  C. Colton,et al.  Apolipoprotein E and Peptide Mimetics Modulate Inflammation by Binding the SET Protein and Activating Protein Phosphatase 2A , 2011, The Journal of Immunology.

[42]  J. Fardell,et al.  Neurobiological basis of chemotherapy-induced cognitive impairment: A review of rodent research , 2011, Neuroscience & Biobehavioral Reviews.

[43]  Eric J Feuer,et al.  Projections of the cost of cancer care in the United States: 2010-2020. , 2011, Journal of the National Cancer Institute.

[44]  Andrew J Saykin,et al.  Longitudinal assessment of cognitive changes associated with adjuvant treatment for breast cancer: impact of age and cognitive reserve. , 2010, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[45]  Sung-Ho Kim,et al.  Cyclophosphamide impairs hippocampus-dependent learning and memory in adult mice: Possible involvement of hippocampal neurogenesis in chemotherapy-induced memory deficits , 2010, Neurobiology of Learning and Memory.

[46]  P. Matthews,et al.  Distinct patterns of brain activity in young carriers of the APOE e4 allele , 2009, NeuroImage.

[47]  C. Kelche,et al.  Middle-aged human apoE4 targeted-replacement mice show retention deficits on a wide range of spatial memory tasks , 2008, Behavioural Brain Research.

[48]  C. Jack,et al.  MRI of hippocampal volume loss in early Alzheimer's disease in relation to ApoE genotype and biomarkers , 2008, Brain : a journal of neurology.

[49]  R. Raffa,et al.  Effects of chemotherapeutic agents 5-fluorouracil and methotrexate alone and combined in a mouse model of learning and memory , 2008, Psychopharmacology.

[50]  M. Simionescu,et al.  Inflammatory Signaling Pathways Regulating ApoE Gene Expression in Macrophages* , 2007, Journal of Biological Chemistry.

[51]  D. Butterfield,et al.  Adriamycin‐mediated nitration of manganese superoxide dismutase in the central nervous system: insight into the mechanism of chemobrain , 2007, Journal of neurochemistry.

[52]  R. Roesler,et al.  Cancer Chemotherapy and Cognitive Function in Rodent Models: Memory Impairment Induced by Cyclophosphamide in Mice , 2006, Clinical Cancer Research.

[53]  D. Schmechel,et al.  Marked regional differences of brain human apolipoprotein e expression in targeted replacement mice , 2004, Neuroscience.

[54]  S. Dunnett,et al.  Behavioural profiles of inbred mouse strains used as transgenic backgrounds. II: cognitive tests , 2004, Genes, brain, and behavior.

[55]  L. Baxter,et al.  Longitudinal changes in cognition and behavior in asymptomatic carriers of the APOE e4 allele , 2004, Neurology.

[56]  R. Theriault,et al.  The cognitive sequelae of standard‐dose adjuvant chemotherapy in women with breast carcinoma , 2004, Cancer.

[57]  J. Wesson Ashford,et al.  ApoE genotype accounts for the vast majority of AD risk and AD pathology , 2004, Neurobiology of Aging.

[58]  A. Granholm,et al.  Ovarian hormones and cognition in the aged female rat: I. Long-term, but not short-term, ovariectomy enhances spatial performance. , 2003, Behavioral neuroscience.

[59]  A. Saykin,et al.  The relationship of APOE genotype to neuropsychological performance in long‐term cancer survivors treated with standard dose chemotherapy , 2003, Psycho-oncology.

[60]  N. Nathoo,et al.  Apolipoprotein E polymorphism and outcome after closed traumatic brain injury: influence of ethnic and regional differences. , 2003, Journal of neurosurgery.

[61]  M. Dewey,et al.  Dementia, cognitive impairment and mortality in persons aged 65 and over living in the community: a systematic review of the literature , 2001, International journal of geriatric psychiatry.

[62]  Karl J. Friston,et al.  Voxel-Based Morphometry—The Methods , 2000, NeuroImage.

[63]  Daniel Bandy,et al.  Hippocampal volumes in cognitively normal persons at genetic risk for Alzheimer's disease , 1998, Annals of neurology.

[64]  G. Rebeck,et al.  APOE Genotype Alters Immunoglobulin Subtypes in Knock-In Mice. , 2015, Journal of Alzheimer's disease : JAD.

[65]  A. Smit,et al.  Cognitive impact of cytotoxic agents in mice , 2014, Psychopharmacology.

[66]  P. Wigmore The effect of systemic chemotherapy on neurogenesis, plasticity and memory. , 2013, Current topics in behavioral neurosciences.

[67]  C. Rampon,et al.  Adult Hippocampal Neurogenesis, Synaptic Plasticity and Memory: Facts and Hypotheses , 2007, Reviews in the neurosciences.

[68]  R. Martins,et al.  APOE-ε4 and APOE −491A polymorphisms in individuals with subjective memory loss , 2002, Molecular Psychiatry.

[69]  R. Packer,et al.  An animal model to detect the neuropsychological toxicity of anticancer agents. , 1989, Medical and pediatric oncology.

[70]  L. Rorke,et al.  An animal model to detect learning deficits following treatment of the immature brain. Studies using radiation and methotrexate. , 1983, Child's brain.