Sulforaphane induces inhibition of human umbilical vein endothelial cells proliferation by apoptosis

[1]  H. Bartsch,et al.  Inhibition of angiogenesis and endothelial cell functions are novel sulforaphane-mediated mechanisms in chemoprevention , 2006, Molecular Cancer Therapeutics.

[2]  H. Nagawa,et al.  Selective inhibition of cyclooxygenase (COX)‐2 inhibits endothelial cell proliferation by induction of cell cycle arrest , 2005, International journal of cancer.

[3]  H. Nagawa,et al.  3-Hydroxy-3-methylglutaryl-coenzyme A reductase inhibitor (pravastatin) inhibits endothelial cell proliferation dependent on G1 cell cycle arrest , 2004, Anti-cancer drugs.

[4]  S. Srivastava,et al.  Sulforaphane-induced G2/M Phase Cell Cycle Arrest Involves Checkpoint Kinase 2-mediated Phosphorylation of Cell Division Cycle 25C* , 2004, Journal of Biological Chemistry.

[5]  P. Hrelia,et al.  Cyclin D3 and p53 mediate sulforaphane-induced cell cycle delay and apoptosis in non-transformed human T lymphocytes , 2002, Cellular and Molecular Life Sciences CMLS.

[6]  Kozo Nakamura,et al.  p53AIP1 regulates the mitochondrial apoptotic pathway. , 2002, Cancer research.

[7]  P. Hrelia,et al.  Growth inhibition, cell-cycle arrest and apoptosis in human T-cell leukemia by the isothiocyanate sulforaphane. , 2002, Carcinogenesis.

[8]  T. Ahmed,et al.  Sulforaphane and its metabolite mediate growth arrest and apoptosis in human prostate cancer cells. , 2002, International journal of oncology.

[9]  T. Shapiro,et al.  Quantitative determination of dithiocarbamates in human plasma, serum, erythrocytes and urine: pharmacokinetics of broccoli sprout isothiocyanates in humans. , 2002, Clinica chimica acta; international journal of clinical chemistry.

[10]  A. Dinkova-Kostova,et al.  Powerful and prolonged protection of human retinal pigment epithelial cells, keratinocytes, and mouse leukemia cells against oxidative damage: The indirect antioxidant effects of sulforaphane , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[11]  Lingxiang Ye,et al.  Total intracellular accumulation levels of dietary isothiocyanates determine their activity in elevation of cellular glutathione and induction of Phase 2 detoxification enzymes. , 2001, Carcinogenesis.

[12]  J. Hayes,et al.  Dietary indoles and isothiocyanates that are generated from cruciferous vegetables can both stimulate apoptosis and confer protection against DNA damage in human colon cell lines. , 2001, Cancer research.

[13]  A. Whittemore,et al.  Vegetables, fruits, legumes and prostate cancer: a multiethnic case-control study. , 2000, Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.

[14]  W. Willett,et al.  Intakes of fruits, vegetables, and related nutrients and the risk of non-Hodgkin's lymphoma among women. , 2000, Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.

[15]  Y Li,et al.  [Mitochondria and apoptosis]. , 2000, Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine].

[16]  Pengfei Li,et al.  Sulforaphane, a naturally occurring isothiocyanate, induces cell cycle arrest and apoptosis in HT29 human colon cancer cells. , 2000, Cancer research.

[17]  J. Stanford,et al.  Fruit and vegetable intakes and prostate cancer risk. , 2000, Journal of the National Cancer Institute.

[18]  S. Hecht,et al.  INHIBITION OF CARCINOGENESIS BY ISOTHIOCYANATES* , 2000, Drug metabolism reviews.

[19]  T. Tsuruo,et al.  Inhibition of haematogenous metastasis of colon cancer in mice by a selective COX-2 inhibitor, JTE-522 , 1999, British Journal of Cancer.

[20]  Masashi Narita,et al.  Bcl-2 family proteins regulate the release of apoptogenic cytochrome c by the mitochondrial channel VDAC , 1999, Nature.

[21]  S. Hecht,et al.  Chemoprevention of cancer by isothiocyanates, modifiers of carcinogen metabolism. , 1999, The Journal of nutrition.

[22]  P. Talalay,et al.  Mechanism of differential potencies of isothiocyanates as inducers of anticarcinogenic Phase 2 enzymes. , 1998, Cancer research.

[23]  J. Hankin,et al.  Total Isothiocyanate Contents in Cooked Vegetables Frequently Consumed in Singapore , 1998 .

[24]  J. Fahey,et al.  Broccoli sprouts: an exceptionally rich source of inducers of enzymes that protect against chemical carcinogens. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[25]  Douglas Hanahan,et al.  Signaling Vascular Morphogenesis and Maintenance , 1997, Science.

[26]  L. Kohlmeier,et al.  Controversies surrounding diet and breast cancer , 1997, Proceedings of the Nutrition Society.

[27]  D. Green,et al.  The Release of Cytochrome c from Mitochondria: A Primary Site for Bcl-2 Regulation of Apoptosis , 1997, Science.

[28]  P. Talalay,et al.  Chemoprotection against cancer by isothiocyanates and glucosinolates. , 1996, Biochemical Society transactions.

[29]  P. Talalay,et al.  Electrophile and antioxidant regulation of enzymes that detoxify carcinogens. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[30]  T. Kensler,et al.  Anticarcinogenic activities of sulforaphane and structurally related synthetic norbornyl isothiocyanates. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[31]  C. Cho,et al.  A major inducer of anticarcinogenic protective enzymes from broccoli: isolation and elucidation of structure. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[32]  L. Wattenberg Inhibitory effects of benzyl isothiocyanate administered shortly before diethylnitrosamine or benzo[a]pyrene on pulmonary and forestomach neoplasia in A/J mice. , 1987, Carcinogenesis.

[33]  S. Amin,et al.  Inhibition of benzo(a)pyrene-induced lung tumorigenesis in A/J mice by dietary N-acetylcysteine conjugates of benzyl and phenethyl isothiocyanates during the postinitiation phase is associated with activation of mitogen-activated protein kinases and p53 activity and induction of apoptosis. , 2002, Cancer research.

[34]  J. Fahey,et al.  The chemical diversity and distribution of glucosinolates and isothiocyanates among plants. , 2001, Phytochemistry.

[35]  J. Folkman Angiogenesis in cancer, vascular, rheumatoid and other disease , 1995, Nature Medicine.