Prognosis and prognostic research: what, why, and how?

Doctors have little specific research to draw on when predicting outcome. In this first article in a series Karel Moons and colleagues explain why research into prognosis is important and how to design such research

[1]  W. Sauerbrei,et al.  Radiation therapy after breast-conserving surgery; first results of a randomised clinical trial in patients with low risk of recurrence. , 2004, European journal of cancer.

[2]  S. Lemeshow,et al.  A new Simplified Acute Physiology Score (SAPS II) based on a European/North American multicenter study. , 1993, JAMA.

[3]  Yvonne Vergouwe,et al.  Prognosis and prognostic research: validating a prognostic model , 2009, BMJ : British Medical Journal.

[4]  J André Knottnerus,et al.  Between iatrotropic stimulus and interiatric referral: the domain of primary care research. , 2002, Journal of clinical epidemiology.

[5]  B. Davies Airs, waters and places , 1985, Environmental geochemistry and health.

[6]  D. G. Altman,et al.  Statistical aspects of prognostic factor studies in oncology. , 1994, British Journal of Cancer.

[7]  Frank Davidoff,et al.  Predicting Clinical States in Individual Patients , 1996, Annals of Internal Medicine.

[8]  J. Wyatt,et al.  Commentary: Prognostic models: clinically useful or quickly forgotten? , 1995 .

[9]  W. Knaus The APACHE III Prognostic System , 1992 .

[10]  Carl van Walraven,et al.  Time-dependent bias was common in survival analyses published in leading clinical journals. , 2004, Journal of clinical epidemiology.

[11]  A. Harris,et al.  REporting recommendations for tumour MARKer prognostic studies (REMARK) , 2005, British Journal of Cancer.

[12]  H. Sox,et al.  Clinical prediction rules. Applications and methodological standards. , 1985, The New England journal of medicine.

[13]  D G Altman,et al.  What do we mean by validating a prognostic model? , 2000, Statistics in medicine.

[14]  E. C. Kelly,et al.  The Genuine Works of Hippocrates , 1939, Annals of Medical History.

[15]  E. Christensen Prognostic models including the Child-Pugh, MELD and Mayo risk scores--where are we and where should we go? , 2004, Journal of hepatology.

[16]  D E Grobbee,et al.  External validation is necessary in prediction research: a clinical example. , 2003, Journal of clinical epidemiology.

[17]  Yvonne Vergouwe,et al.  Bmc Medical Research Methodology Open Access Advantages of the Nested Case-control Design in Diagnostic Research , 2022 .

[18]  J. Concato,et al.  Importance of events per independent variable in proportional hazards regression analysis. II. Accuracy and precision of regression estimates. , 1995, Journal of clinical epidemiology.

[19]  Hippocrates,et al.  The Genuine Works Of Hippocrates , 1849 .

[20]  A. Hoes,et al.  Confounding and indication for treatment in evaluation of drug treatment for hypertension , 1997, BMJ.

[21]  G H Guyatt,et al.  Users' guides to the medical literature: XXII: how to use articles about clinical decision rules. Evidence-Based Medicine Working Group. , 2000, JAMA.

[22]  Cor J Kalkman,et al.  Does Measurement of Preoperative Anxiety Have Added Value for Predicting Postoperative Nausea and Vomiting? , 2005, Anesthesia and analgesia.

[23]  C K Redmond,et al.  Tamoxifen for prevention of breast cancer: report of the National Surgical Adjuvant Breast and Bowel Project P-1 Study. , 1999, Journal of the National Cancer Institute.

[24]  Ewout W Steyerberg,et al.  Validation and updating of predictive logistic regression models: a study on sample size and shrinkage , 2004, Statistics in medicine.

[25]  Andrew D Oxman,et al.  Users' Guides to the Medical Literature , 2006 .

[26]  Charles E McCulloch,et al.  Relaxing the rule of ten events per variable in logistic and Cox regression. , 2007, American journal of epidemiology.

[27]  B C James,et al.  Making it easy to do it right. , 2001, The New England journal of medicine.

[28]  F. Harrell,et al.  Prognostic/Clinical Prediction Models: Multivariable Prognostic Models: Issues in Developing Models, Evaluating Assumptions and Adequacy, and Measuring and Reducing Errors , 2005 .

[29]  James E. Calvin,et al.  Understanding articles describing clinical prediction tools , 1998 .

[30]  J. Concato,et al.  The Risk of Determining Risk with Multivariable Models , 1993, Annals of Internal Medicine.

[31]  P Peduzzi,et al.  Importance of events per independent variable in proportional hazards analysis. I. Background, goals, and general strategy. , 1995, Journal of clinical epidemiology.

[32]  W. Kannel,et al.  A general cardiovascular risk profile: the Framingham Study. , 1976, The American journal of cardiology.

[33]  Gordon H. Guyatt,et al.  Users' Guides to the Medical Literature: V. How to Use an Article About Prognosis , 1994 .

[34]  C. Goldsmith,et al.  How to use an article about prognosis. , 2009, Canadian journal of surgery. Journal canadien de chirurgie.

[35]  Daniel J Brotman,et al.  In search of fewer independent risk factors. , 2005, Archives of internal medicine.

[36]  E. Balas,et al.  Improving clinical practice using clinical decision support systems: a systematic review of trials to identify features critical to success , 2005, BMJ : British Medical Journal.

[37]  Alvan Feinstein,et al.  Clinical Judgment Revisited: The Distraction of Quantitative Models , 1994, Annals of Internal Medicine.

[38]  A. Laupacis,et al.  Clinical prediction rules. A review and suggested modifications of methodological standards. , 1997, JAMA.

[39]  Yvonne Vergouwe,et al.  Prognosis and prognostic research: Developing a prognostic model , 2009, BMJ : British Medical Journal.

[40]  P. Royston,et al.  Prognosis and prognostic research: application and impact of prognostic models in clinical practice , 2009, BMJ : British Medical Journal.

[41]  N Roewer,et al.  A simplified risk score for predicting postoperative nausea and vomiting: conclusions from cross-validations between two centers. , 1999, Anesthesiology.

[42]  J. Concato Challenges in prognostic analysis , 2001, Cancer.

[43]  L I Iezzoni,et al.  Explaining differences in English hospital death rates using routinely collected data , 1999, BMJ.

[44]  A. Evans,et al.  Translating Clinical Research into Clinical Practice: Impact of Using Prediction Rules To Make Decisions , 2006, Annals of Internal Medicine.

[45]  C. Kalkman,et al.  Preoperative Risk Factors of Intraoperative Hypothermia in Major Surgery Under General Anesthesia , 2003, Anesthesia and analgesia.

[46]  W. Knaus,et al.  The APACHE III prognostic system. Risk prediction of hospital mortality for critically ill hospitalized adults. , 1991, Chest.

[47]  P C Lambert,et al.  Reporting of prognostic markers: current problems and development of guidelines for evidence-based practice in the future , 2003, British Journal of Cancer.

[48]  K. Covinsky,et al.  Assessing the Generalizability of Prognostic Information , 1999, Annals of Internal Medicine.

[49]  I. Ellis,et al.  The Nottingham prognostic index in primary breast cancer , 2005, Breast Cancer Research and Treatment.